Impact of ambient air pollution exposure during preconception and pregnancy on risk of gestational diabetes mellitus: A retrospective cohort study in China.

The association between air pollution exposure and gestational diabetes mellitus (GDM) have been studied extensively; however, conclusions regarding the sensitive exposure period and effect of exposure remain inconsistent. We conducted a retrospective cohort study involving 2593 pregnant participants from Kunshan, China. Daily concentrations of particulate matter less than 2.

Placental DNA methylation changes in gestational diabetes mellitus.

In this study, we investigated the association between altered methylation in the maternal placenta and hyperglycaemia and explored the epigenetic mechanisms underlying gestational diabetes mellitus (GDM). Reduced representation bisulphite sequencing (RRBS) and RNA sequencing (RNA-seq) were performed on placental tissues obtained from women with GDM and healthy controls. Further, pyrosequencing, correlation analyses, and linear regression analyses were performed to valuate relationships between aberrantly methylated-differentially expressed genes and clinical parameters.

Epigenetic alternations of microRNAs and DNA methylation contribute to gestational diabetes mellitus.

This study aimed to identify epigenetic alternations of microRNAs and DNA methylation for gestational diabetes mellitus (GDM) diagnosis and treatment using in silico approach. Data of mRNA and miRNA expression microarray (GSE103552 and GSE104297) and DNA methylation data set (GSE106099) were obtained from the GEO database. Differentially expressed genes (DEGs), differentially expressed miRNAs (DEMs) and differentially methylated genes (DMGs) were obtained by limma package.