Daidzin Inhibits Endoplasmic Reticulum Stress by Regulating FoxO1 Expression to Alleviate Osteoarthritis Progression.

Endoplasmic reticulum stress (ERS) and chondrocyte apoptosis are recognized as critical pathological factors in the development of osteoarthritis (OA). Daidzin (DDZ), an isoflavone derived from soybean, exhibits antioxidant, anticancer, and anti-atherosclerotic properties. This research seeks to investigate the therapeutic potential and primary mechanisms of Daidzin using a murine Destabilization of the Medial Meniscus instability model and a TBHP-induced in vitro OA chondrocyte model.

Repeated transcranial magnetic stimulation on the bilateral cerebellum to improve symptoms of ataxia with multiple system atrophy: a prospective, randomized, sham-controlled pilot study.

Objectives: Ataxia is a common symptom in patients with Cerebellar subtype of Multiple system atrophy (MSA-C), but effective treatments remain elusive. The present study aims to investigate whether repetitive transcranial magnetic stimulation (rTMS) over the bilateral cerebellum could relieve ataxia in patients with MSA-C.

Patients And Methods: This is a single-center, randomized and double-blind trial.

Policy, technical change, and environmental efficiency: Evidence of China's power system from dynamic and spatial perspective.

Feed-in tariff (FIT) and renewable portfolio standard (RPS) policies have been implemented to facilitate wind and solar power technologies with the aim of achieving sustainable development in power system. It is essential to study how efficient these policies are in accelerating technical progress and how efficient the power system is in balancing development and environmental protection. Dynamic network data envelopment analysis and the global Malmquist productivity index are first employed to study the environmental efficiency and technical progress, after which a dynamic spatial Durbin model is applied to analyze the impact of policies on technical progress.

Bridging planetary boundaries and spatial heterogeneity in a hybrid approach: A focus on Chinese provinces and industries.

Communicating the finiteness of the Earth system at sub-global scales is necessary to guide human activities within a safe operating space. Despite the numerous efforts committed to downscaling planetary boundaries (PBs) at multiple scales, neither top-down nor bottom-up approaches adequately account for the spatial heterogeneity and integrity of local and global natural systems. To overcome these shortcomings, we developed a hybrid approach that combines bottom-up aggregation and top-down adjustment for downscaling five crucial PBs (i.

Revisiting the application and methodological extensions of the planetary boundaries for sustainability assessment.

The planetary boundaries (PBs) delineating the safe operating space for human activities have been broadly recognized as a well-grounded framework for global sustainability assessment. This paper provides a comprehensive review of the application and methodological extensions of the PBs by linking with multiscale environmental sustainability assessments. We find that the targeted scales, sharing principles and sustainability perspectives jointly determine the downscaling of the PBs-a complex process that needs to take into account the biophysical, socioeconomic, ethical and cultural dimensions.

[Land use and land cover charnge (LUCC) and landscape service: Evaluation, mapping and modeling].

Studies on ecosystem service from landscape scale aspect have received increasing attention from researchers all over the world. Compared with ecosystem scale, it should be more suitable to explore the influence of human activities on land use and land cover change (LUCC), and to interpret the mechanisms and processes of sustainable landscape dynamics on landscape scale. Based on comprehensive and systematic analysis of researches on landscape service, this paper firstly discussed basic concepts and classification of landscape service.