Publications by authors named "Wuqiang Lin"
Article Synopsis
- The study focuses on chronic myeloid leukemia (CML) patients who experience drug resistance that is not dependent on the BCR::ABL1 mutation, aiming to uncover the underlying mechanisms of this resistance to improve treatment strategies.
- Researchers conducted RNA sequencing to compare long non-coding RNA (lncRNA) and messenger RNA (mRNA) expression between patients who achieve deep molecular response (DMR) after treatment and those who do not (non-DMR).
- The analysis revealed distinct lncRNA profiles linked to drug resistance, indicating that overexpression of certain lncRNAs could play a role in TKI resistance among CML patients, leading to further investigation into potential therapeutic targets.
Article Synopsis
- - Adult T-cell leukemia/lymphoma (ATLL) is a serious cancer with a grim outlook, and limited data exists on its effects specifically in the Chinese population; this study looked at 115 patients treated in China over more than a decade.
- - Key genetic mutations related to T-cell receptor signaling were found in patients, with most of them receiving chemotherapy; the study showed that EPOCH/CHOEP chemotherapy resulted in an 80.6% response rate, while the overall survival rates varied significantly based on treatment type.
- - Factors like lymphadenopathy, the use of EPOCH/CHOEP chemotherapy, and hematopoietic stem cell transplantation were identified as important in improving patient outcomes, signaling that these treatments
Article Synopsis
- A 50-year-old man diagnosed with myelodysplastic syndrome underwent a successful stem cell transplant in 2019 but later developed multiple autoimmune disorders in 2021, known as multiple autoimmune syndrome (MAS).
- Despite treatment with glucocorticoids and other medications, he did not fully recover from MAS.
- A four-week course of rituximab significantly improved his condition, emphasizing the need for alternative treatments in patients with treatment-resistant post-transplant autoimmune diseases.
To investigate the value of metagenomic next-generation sequencing (mNGS) in acute leukemia (AL) patients with febrile neutropenia (FN). We retrospectively reviewed 37 AL patients with FN and compared the results of mNGS with blood culture (BC) and the clinical features of the mNGS-positive group and the mNGS-negative group. A total of 14 detected pathogens were the final clinical diagnosis, of which 9 strains were detected only by mNGS and 5 strains were detected by both mNGS and BC.
View Article and Find Full Text PDFObjective: Cell division cycle 37 (CDC37) modulates disease progression and bortezomib resistance in multiple myeloma by regulating X-box binding protein 1, nuclear factor-kappa-B, etc. This study aimed to explore the prognostic implication of CDC37 before and after bortezomib-based induction treatment in multiple myeloma patients.
Methods: CDC37 was detected from plasma cells of bone marrow by reverse transcription-quantitative polymerase chain reaction at baseline and after bortezomib-based induction treatment in 82 multiple myeloma patients, and in 20 disease controls and 20 healthy controls.
Insights from a patient with chronic lymphocytic leukemia complicating ALK anaplastic large cell lymphoma.
Intractable Rare Dis Res
November 2022
Chronic lymphocytic leukemia (CLL) that transforms into a more aggressive lymphoma has been termed Richter syndrome (RS). CLL with T-cell neoplasia is rarely reported; those with ALK anaplastic large cell lymphoma (ALCL) are also exceedingly rarely reported. A 63-year-old woman from the south of China presented with generalized lymphadenectasis and fever; she already had a prior diagnosis of CLL 9 years ago.
View Article and Find Full Text PDF[Emodin Induces Apoptosis of K562/Adr Cells Probably through Akt-Caspase 3 Signal Pathway].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2015
Objective: To investigate the apoptosis-inducing effects of emodin on multidrug resistant leukemia cell line K562/Adr, and to explore the role of Akt-Caspase 3 signal pathway in apoptosis of K562/Adr cells treated with emodin.
Methods: K562/Adr cells were exposed to emodin of different doses. The ability of emodin to induce apoptosis of K562/Adr cells was detected by Annexin V/PI double labeled flow cytometry and DNA ploidy analysis, the expressions of procaspase-3, PARP, Akt, p-Akt protein were determined by Western blot.