A turn-on fluorescent probe for imaging of hydroxyl radicals in drug-induced liver injury.

Hydroxyl radical is the most oxidizing type of reactive oxygen species (ROS), which is closely related to body health. In this work, a novel turn-on fluorescent probe BIJ-H for OH with high sensitivity was reported. BIJ-H was synthesized by a three-step reaction, and the pure product was obtained by only washing with poor solvents.

Retrocerebellar arachnoid cyst resulting in syringomyelia in a patient without tonsillar herniation: successful surgical treatment with reconstruction of CSF flow in the foramen magnum region.

A retrocerebellar arachnoid cyst causing syringomyelia is extremely rare without tonsillar herniation. The authors present a 44-year-old woman with symptoms of foramen magnum compression and syringomyelia. Magnetic resonance imaging demonstrated a large retrocerebellar arachnoid cyst with a large cervicothoracic syrinx but no signs of tonsillar herniation or hydrocephalus.

STI571 protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis.

Prion diseases are neurodegenerative disorders caused by the accumulation of misfolded prion proteins [scrapie form of PrP (PrP(Sc))]. PrP(Sc) accumulation in the brain causes neurotoxicity by inducing mitochondrial-apoptotic pathways. Neurodegeneration can be prevented by imatinib mesylate (Gleevec or STI571) that regulates c-Abl tyrosine kinases, which elicit protective effects in neurodegenerative disease models.

[Effect of probiotics on Newcastle Disease Virus].

Objective: We studied the antiviral activity of probiotics and possible mechanism thereof.

Methods: With hemagglutination in vitro and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) of chicken embryo fibroblast (CEF), the hemagglutination titers and virus inhibition rate were respectively determined to evaluate the impact of probiotics on Newcastle Disease Virus (NDV).

Results: Five probiotics and their metabolites could reduce the viral titer of NDV, but the two pathogenic bacteria and their metabolites could not.