The effects of test on associative memory depend on semantic relevancy levels: evidence of event-related potentials.

This study aims to investigate how the level of semantic relevance influences the effects of test on associative memory through bottom-up cognitive processes. This study manipulated the levels of semantic relevancy using synonym and nonsynonym pairs in a three-phase testing effect paradigm (an initial encoding phase, a cued-recall test as retrieval practice, and a final test phase) to explore the effects of testing effect and semantic relevancy on associative recognition by bottom-up processes using the event-related potential (ERP). The behavioral results suggested that the test practice (relative to the restudy) significantly facilitated memory retrieval in high semantic relevancy pairs during the final test phase.

SRT1720 Treatments Hepatic Ischemia Reperfusion Injury by Regulation of NF-κB Signaling Pathways and Reduce Cell Apoptosis: From Network Pharmacology to Experimental Validation.

Background And Objective: Hepatic ischemia reperfusion injury (HIRI) is a common complication closely related to the prognosis of liver surgery, and effective treatment methods are still unavailable. SRT1720 has the characteristics of multifunction and multitarget which may cope with the multidirectional complex pathological process caused by HIRI. The present study aimed to explore the potential mechanism of SRT1720 in HIRI through a combination of network pharmacology, experiments and in vivo models.

The effect of reward expectation on working memory of emotional faces under different levels of cognitive load: an ERP study.

Using event-related potentials (ERPs), this study examined the impact of reward expectations on working memory of emotional faces under different levels of cognitive load in a task combining the N-back paradigm and the reward expectation paradigm. The experiment involved presenting high- or low-reward cues followed by an N-back task for emotional faces with different loads. The accuracy results showed that under a high task load, both reward and emotion effects were significantly observed.

Multi-trajectories of systolic and diastolic hypertension and coronary heart disease in middle-aged and older adults.

Objective: This study aimed to investigate multi-trajectories of systolic and diastolic hypertension and assess their association with the risk of coronary heart disease (CHD) in middle-aged and older Chinese adults.

Methods: The study cohort comprised 4,102 individuals aged 40-75 years with records of at least four systolic blood pressure (SBP) and diastolic blood pressure (DBP). A group-based multi-trajectory model was adopted to identify multi-trajectories of systolic and diastolic hypertension, followed by a logistic model to assess the independent associations between these trajectories and CHD risk.

LncRNA PCAT7 promotes non-small cell lung cancer progression by activating miR-486-5p/CDK4 axis-mediated cell cycle.

Objective: Lung cancer remains one of the common cancers worldwide. Both LncRNA PCAT7 and miR-486-5p are tightly correlated with NSCLC. However, the relationship between PCAT7 and miR-486-5p and the detailed mechanisms underlying the effect of PCAT7 on NSCLC are not discovered yet.