Waist-to-Height Ratio Is a Stronger Mediator in the Association between DASH Diet and Hypertension: Potential Micro/Macro Nutrients Intake Pathways.

Several studies have demonstrated that adhering to the Dietary Approaches to Stop Hypertension (DASH) diet may result in decreased blood pressure levels and hypertension risk. This may be an effect of a reduction in central obesity. In the current study, we explored the mediation role of multiple anthropometric measurements in association with DASH score and hypertension risk, and we investigated potential common micro/macro nutrients that react with the obesity-reduction mechanism.

Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells.

Background: 24-epibrassinolide (EBR) is a ubiquitous steroidal phytohormone with anticancer activity. Yet the cytotoxic effects and mechanism of EBR on hepatocarcinoma (HCC) cells remain elusive.

Methods: Cell counting kit-8 (CCK-8) assay was performed to evaluate cell viability.

6-methoxydihydroavicine, the alkaloid extracted from Macleaya cordata (Willd.) R. Br. (Papaveraceae), triggers RIPK1/Caspase-dependent cell death in pancreatic cancer cells through the disruption of oxaloacetic acid metabolism and accumulation of reactive oxygen species.

Background: Many extracts and purified alkaloids of M. cordata (Papaveraceae family) have been reported to display promising anti-tumor effects by inhibiting cancer cell growth and inducing apoptosis in many cancer types. However, no evidence currently exists for anti-pancreatic cancer activity of alkaloids extracted from M.

An immunogenomic signature for molecular classification in hepatocellular carcinoma.

Immunity plays an important role in tumor development. In this study, we aimed to investigate molecular classification and its prognostic value in hepatocellular carcinoma (HCC) based on immune signature. Gene set enrichment analysis (GSEA) was used to calculate scores of immune pathways for HCC and hierarchical clustering in two databases (The Cancer Genome Atlas [TCGA], Liver Cancer-RIKEN, JP [LIRI_JP]).

Statistical inference for a relaxation index of stochastic dominance under density ratio model.

Stochastic dominance is usually used to rank random variables by comparing their distributions, so it is widely applied in economics and finance. In actual applications, complete stochastic dominance is too demanding to meet, so relaxation indexes of stochastic dominance have attracted more attention. The index, the biggest gap between two distributions, can be a measure of the degree of deviation from complete dominance.

A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by Inducing GSDME Dependent Pyroptosis.

Cannabidiol (CBD), a phytochemical derived from L., has been demonstrated to exhibit promising anti-tumor properties in multiple cancer types. However, the effects of CBD on hepatocellular carcinoma (HCC) cells remain unknown.

Testing exponentiality based on the extropy of record values.

In this paper, we first present a characterization of exponential distribution based on the extropy of record values and next introduce a goodness-of-fit test for exponentiality. Monte Carlo simulation is used to compute the critical values of our proposed test for different sample sizes and significance levels. To show the advantage of the proposed test, we adopt 58 competitor tests and compute the adjusted power against different alternatives with distinct types of hazard function.

Investigation on vitamin D knowledge, attitude and practice of university students in Nanjing, China.

Objective: To investigate university students' knowledge, attitudes and practice (KAP) regarding vitamin D.

Design: The students were requested to answer a questionnaire related to vitamin D and sun exposure. The consumption frequency of foods rich in vitamin D was assessed.

Synthesis of Homoleptic Neopentoxide and Hydrido-Neopentoxide Trirhenium(III) Clusters.

The purpose of this study was to synthesize Re(3)(&mgr;-OCH(2)CMe(3))(3)(OCH(2)CMe(3))(6) and to determine if it could serve as a source of Re(3)(&mgr;-OCH(2)CMe(3))(3)(H)(OCH(2)CMe(3))(5) by analogy to Re(3)(&mgr;-O-i-Pr)(3)(O-i-Pr)(6), a previously reported cluster that exists in solution as an equilibrium mixture with Re(3)(&mgr;-O-i-Pr)(3)(H)(O-i-Pr)(5) and acetone. The halide Re(3)(&mgr;-Cl)(3)Cl(6)(THF)(3) reacts at room temperature in THF with 9 equiv of NaOCH(2)CMe(3) to give Re(3)(&mgr;-OCH(2)CMe(3))(3)(OCH(2)CMe(3))(6). An X-ray crystallographic study shows that the core of the homoleptic cluster has virtual D(3h) symmetry, which is consistent with solution NMR data.