Publications by authors named "Vishal Hegde"

Purpose: Persistent postoperative knee pain after primary total knee arthroplasty (TKA) is often an indication for revision surgery and has a multifactorial etiology. Periarticular neuromas of nerves innervating the joint, ligaments, or overlying skin are important but misdiagnosed causes of persistent knee pain following knee surgery. This study aimed to characterize the incidence and sequelae of peripheral neuromas in TKA patients.

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The American Joint Replacement Registry continues to grow, as represented by the 4.3 million hip and knee arthroplasties analyzed in the 2024 American Joint Replacement Registry . Highlights of this report are found in the following article.

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Background: Osteonecrosis is a debilitating condition characterized by bone tissue death and disrupted vascular circulation, most commonly affecting the femoral head. This study aimed to assess the epidemiology and surgical trends of hip osteonecrosis in the United States using a comprehensive national database, as well as to review the current literature on historical and contemporary surgical trends for patients who have osteonecrosis of the femoral head (ONFH).

Methods: Data from a research network (2015 to 2024) were used to identify patients diagnosed with ONFH using International Classification of Diseases, 10th revision, Clinical Modification codes.

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Background: Increased use of condylar-stabilized (CS) bearings in primary total knee arthroplasty can be attributed to bony preservation with the option for posterior cruciate ligament resection without compromising kinematics. There are a variety of CS designs, but no system of nomenclature, making comparisons challenging. A comprehensive classification system of differing CS designs based on articular surface and femoral component geometries and kinematic principles is proposed.

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Background: Mobile-bearing (MB) total knee arthroplasty (TKA) designs have proposed biomechanical benefits, including improved patellar tracking and reduction in polyethylene wear. Yet, prior work using the American Joint Replacement Registry (AJRR) has demonstrated an increased risk of all-cause revision with MB-TKA. We therefore utilized the AJRR to further characterize reasons for the increased risk of revision with MB-TKA compared to fixed-bearing (FB) TKA designs.

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Background: Compared to other cementless designs, collared metadiaphyseal-filling femoral stems are associated with a lower risk of revision and periprosthetic femoral fracture after total hip arthroplasty (THA) in patients ≥ 65 years. However, it is unclear how these designs compare to cemented femoral stems. We utilized the American Joint Replacement Registry to examine the risk of revision comparing cementless collared metadiaphyseal-filling versus cemented femoral stem designs.

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Background: Patella resurfacing in total knee arthroplasty (TKA) involves surgical manipulation of the extensor mechanism, which can weaken or devascularize the patellar bone, quadriceps, and patellar tendon. Patella resurfacing may, in theory, increase the risk of postoperative extensor mechanism disruption (EMD).

Methods: We systematically searched the Cochrane, Embase, and PubMed databases to identify randomized controlled trials that reported the overall incidence of complications and surgery for EMD for resurfaced and unresurfaced patellae in patients who underwent primary TKA with a 2-year follow-up.

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Background: Complications following total hip arthroplasty (THA) may necessitate a revision and patients who go on to a revision THA may experience depressive symptoms. The objective of this study was to investigate the prevalence of depressive symptoms before and after revision THA for six different failure modes.

Methods: Patients who underwent a THA revision with minimum 1-year follow-up at a single institution from 2008 to 2022 were retrospectively reviewed.

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Background: Conflicting evidence leaves surgeons without clarity on the association of elevated body mass index (BMI) with the risk of mechanical loosening after total knee arthroplasty (TKA). This investigation examined the associated risk of mechanical loosening following TKA based on BMI.

Methods: We analyzed American Joint Replacement Registry data in patients aged 65 years or more from January 2012 to March 2022 who had a minimum of 2-year follow-up linked to supplemental Centers for Medicare and Medicaid data.

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Background: Unicompartmental knee arthroplasty (UKA) is a surgical treatment for knee osteoarthritis associated with lower morbidity compared with total knee arthroplasty (TKA) in patients with isolated unicompartmental knee arthritis. As disparities have been noted broadly in arthroplasty care, it follows that such disparities might be present in the utilization of UKA relative to TKA. This study therefore examined racial/ethnic, socioeconomic, and payer status differences in utilization of UKA.

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Background: Racial/ethnic disparities in access to total knee arthroplasty (TKA) have been extensively demonstrated. Over the past several years, there has been a rapid increase in the utilization of robot-assisted TKA (RA-TKA). Therefore, this study sought to determine whether previously established racial/ethnic disparities extend to access to RA-TKA relative to conventional TKA.

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The benefit of patellar resurfacing in total knee arthroplasty (TKA) remains uncertain, with conflicting evidence regarding associated revision rates and clinical outcomes. Although initial studies have reported higher revision rates associated with unresurfaced patellae, recent evidence questions the necessity of routine patellar resurfacing. This study aimed to evaluate the risk of revision following TKA performed with and without patellar resurfacing using data from the American Joint Replacement Registry (AJRR).

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Background: Proton pump inhibitors (PPIs) are often prescribed in conjunction with nonsteroidal anti-inflammatory drugs after total hip arthroplasty (THA) and total knee arthroplasty (TKA) due to their gastroprotective effects. In animal studies, it has been suggested that PPIs have immunosuppressive effects and impair fracture healing; however, the association between PPI use and adverse events following THA and TKA has not been well-studied.

Methods: An administrative claims database was queried for patients who underwent elective THA from 2010 to 2019.

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Background: There has been considerable interest in the use of GLP-1 receptor analogs (GLP-1 RAs) for weight optimization in patients undergoing elective arthroplasty. As there is limited data regarding the implications of their use, our study aimed to evaluate the association between preoperative GLP-1 RA use and postoperative outcomes in patients undergoing primary total hip arthroplasty (THA) and total knee arthroplasty (TKA).

Methods: The TrinetX research network was queried to identify all patients undergoing primary THA or TKA between May 2005 and December 2023 across 84 health care organizations.

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Article Synopsis
  • Modern highly porous cementless total knee arthroplasty (TKA) is becoming more common in the U.S., but there's limited research on revision risks for patients aged 65 and older.
  • An analysis of data from the American Joint Replacement Registry revealed no significant differences in revision risks between cementless and cemented TKAs despite demographic variations, such as age and sex.
  • The findings suggest that using cementless fixation in older patients doesn't increase the likelihood of needing revision surgeries, although more research is needed to clarify when cementless options should be used.
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  • Recent advancements in blood management techniques, including the use of tranexamic acid, have led to a significant decrease in transfusion rates following total knee arthroplasty (TKA).
  • A study analyzed data from over 500,000 TKA patients between 2010 and 2021, revealing that the rate of transfusion dropped from 10.6% to 0.6%, while the impact of preoperative anemia on transfusion risk increased significantly.
  • The findings suggest that focusing on preoperative anemia could be crucial to further reducing transfusion needs as blood management protocols continue to improve.
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There is renewed interest in cemented femoral fixation in total hip arthroplasty in the United States, and to fully appreciate the evolution of cemented femoral stem designs, an understanding of their history and design rationale is essential. To adequately study the outcomes of modern-day designs, a comprehensive classification system is also necessary. The biomechanical principles, failure mechanisms, and clinical outcomes associated with various cemented femoral stems are described in this comprehensive review.

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Article Synopsis
  • Obesity negatively affects outcomes of total hip arthroplasty (THA), prompting surgeons to set body mass index limits and recommend preoperative weight loss for patients.
  • A study analyzed THA patients from 2013-2020 to see if losing over 10% of body weight before surgery improved their postoperative results, adjusting for various patient factors.
  • Findings showed that significant preoperative weight loss led to longer hospital stays and higher rates of complications for both general and obese patients, indicating that rapid weight loss may not be beneficial and could worsen outcomes.
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  • The study analyzes the reasons for revision total hip arthroplasty (rTHA) across different body mass index (BMI) classes using data from nearly 100,000 patients between 2006 and 2020.
  • Researchers found that underweight patients had a higher likelihood of revisions due to dislocation and periprosthetic fractures, while overweight and obese patients were more prone to infections.
  • The findings suggest that understanding these differences in reasons for rTHA can help tailor patient care to minimize complications based on BMI.
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  • The study investigates the prevalence of mental health issues, specifically depressive symptoms, in patients undergoing aseptic revision total knee arthroplasty (TKA), highlighting their psychological distress linked to various complications post-surgery.
  • It analyzes data from 394 patients treated between 2008 and 2019, assessing their mental health scores preoperatively and postoperatively across different failure modes.
  • Results indicate that while there was a slight decrease in depressive symptoms from preoperative (23.4%) to postoperative (18.8%), the prevalence of these symptoms remained consistent regardless of the type of knee failure experienced, suggesting a need for better mental health screening and support for these patients.*
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  • The study examines the outcomes of patients with recently diagnosed COVID-19 who underwent surgery for hip fractures compared to those without the virus.
  • Researchers used data from the American College of Surgeons NSQIP database and found that COVID-19-positive patients had a significantly higher risk of complications like pneumonia, unplanned intubation, and septic shock, along with increased 30-day mortality.
  • The findings suggest that active COVID-19 infection is a serious risk factor for surgical complications and longer hospital stays, emphasizing the need for tailored treatment guidelines for these patients.
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Background: Preoperative anemia is common in patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA). Several definitions of anemia have been described, with no clear consensus on the optimal one for preoperative screening. We hypothesized that depending on the definition used preoperatively, the proportion of anemic patients identified who would require a postoperative allogeneic blood transfusion would vary significantly.

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Article Synopsis
  • * The study analyzed data from 2,340 patients through propensity score matching to compare outcomes between COVID-19-positive and negative patients post-surgery.
  • * Understanding these complications can help orthopedic surgeons provide better guidance and risk mitigation strategies for patients, especially those in higher risk categories.
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Introduction: Early postoperative pain following total knee arthroplasty significantly impacts outcomes and patient satisfaction. However, the characteristics and sources of early pain after total knee arthroplasty remain unclear. Therefore, the purpose of this study was to determine the anatomic distribution and course of postoperative pain in the acute and subacute period following total knee arthroplasty.

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