Decoding microbial ecology and functions: metagenomic profiling of activated sludge contaminated with chlorolignin compounds in a pulp-paper mill treatment system.

This study aimed to profile the dynamics of indigenous bacterial communities in activated sludge, assess the pollutant load, and unlock the functional genes involved during the activated sludge treatment process. The physicochemical analyses of activated sludge revealed high amounts of phosphate, sulfate, chloride, and lignin, along with heavy metals like Fe, Zn, Cu, Ni, and Pb. Simultaneously, the GC-MS/MS technique identified decane, 1 bromo-2-methyl, pentadecanoic acid, methyl ester, benzene dicarboxylic acid, stigmasterol, borinic acid, diethyl, 2-hydroxymethyl cyclopropane, 2-methoxy-4-ethyl-phenol, 3,4,5-trichlorophenol, octadecanoic acid, and tetracosanic acid as major compounds.

Advances in Functional Rubber and Elastomer Composites II.

Recently, rubber and elastomer materials have expanded their applications from traditional mechanical uses to advanced mechanical, electrical, and sensor applications [...

Voltage and frequency regulation in wind penetrated deregulated power system using an electric vehicle and IPFC assisted model predictive controller.

This paper presents a coordinated voltage and frequency control strategy for a wind-integrated deregulated dual-area power system comprising three Generation Companies (GENCOs), diesel, thermal, and wind-and three Distribution Companies (DISCOs) in each area. A Harris Hawks Optimization-based Model Predictive Controller (MPC-HHO) is proposed to enhance system performance under three distinct market scenarios: poolco, bilateral, and contract violation modes. The proposed controller is benchmarked against conventional PID, fractional-order PIDF, and MPC schemes optimized via Particle Swarm Optimization (PSO) and Whale Optimization Algorithm (WOA).

Evaluating educational effectiveness of three-dimensional (3D)-printed training models and custom-made fibula model for osteotomy and flap inset training in head and neck reconstruction.

Background: Reconstructive surgery following head and neck cancer resection is inherently complex and technically demanding. Procedures such as osteotomy and flap inset involve a steep learning curve, yet opportunities for hands-on training are increasingly limited. Physical simulation using cost-effective, anatomically realistic models offers a promising solution.

Kinetic and mechanistic investigation toward the characterization of tucatinib inhibition of CYP3A4.

A highly selective tyrosine kinase inhibitor of the human epidermal growth factor receptor 2, tucatinib, has shown remarkable efficacy and safety for treatment of adult patients with advanced, unresectable, or metastatic human epidermal growth factor receptor 2 positive breast cancer, including those with brain metastases. The purpose of this study was to evaluate in vitro the potential to inhibit cytochrome P450 (P450) isoforms for tucatinib. Preliminary in vitro P450 inhibition survey revealed that tucatinib was a weak inhibitor of CYP1A2, CYP2B6, CYP2C19, and CYP2D6 with IC values >20 μM.

High-Performance Barium Titanate, Carbon Nanotube, and Styrene-Butadiene Rubber-Based Single Composite TENG for Energy Harvesting and Handwriting Recognition.

In this research, a single composite-type stretchable triboelectric nanogenerator (TENG) is proposed for efficient energy harvesting and handwriting recognition. The composite TENGs were fabricated by blending dielectric barium titanate (BT) and conductive carbon nanotubes (CNTs) in varying amounts into a styrene-butadiene rubber matrix. The energy harvesting efficiency depends on the type and amount of fillers, as well as their dispersion within the matrix.

Correction: Afjei et al. A New Nrf2 Inhibitor Enhances Chemotherapeutic Effects in Glioblastoma Cells Carrying p53 Mutations. 2022, , 6120.

In the original publication [...

Real-World Chemoport Outcomes in Pediatric Oncology in a Resource-Limited Setting: A Retrospective Analysis With Pragmatic Implications.

Introduction: Reliable long-term venous access is crucial for pediatric oncology, particularly in resource-limited settings where peripheral intravenous access often proves inadequate. Totally implantable venous access devices or chemoports, provide a durable and safe alternative. However, literature from newly established cancer centers in low- and middle-income countries remains sparse.

Multifunctional Polymer Composite Materials.

Recently, polymer composites have evolved from simple polymeric materials into advanced engineering systems capable of delivering multiple functionalities simultaneously [...

Supplementary Tibial Fixation for Anterior Cruciate Ligament (ACL) Reconstruction Using Quadrupled Semitendinosus Graft: A Retrospective Study.

Background Anterior cruciate ligament (ACL) reconstruction has seen significant advancements, but challenges remain, particularly in tibial fixation. Low bone density and prolonged osseous integration of soft tissue grafts compromise fixation, especially in the Indian population. We present a novel technique for supplementary ACL fixation using a transosseous tibial tunnel with a quadrupled semitendinosus graft, eliminating the need for additional hardware and associated complications.

Adherence to Guidelines in Orthopaedic Operation Notes: A Quality Improvement Initiative.

Background: Orthopaedic operation notes are crucial documents that record the specifics of surgical procedures performed on the musculoskeletal system. They play a vital role in ensuring clear communication between peri-operative and post-operative periods, maintaining patient care and safety, and serving as legal documents. However, studies have consistently shown gaps in the documentation of important parameters.

A Retrospective Analysis Comparing the Dosimetric Parameters of Two Rectum-Sparing Techniques During Intracavitary Brachytherapy with Tandem-Ring Applicators for Cervical Cancer.

Purpose: Conventional intracavitary brachytherapy (ICBT) operative procedures with tandem-ring (TR) applicators utilizing standard rectal retractor (RR) blades for rectum separation did not allow for optimal rectum sparing, especially in patients with roomy vagina. This limitation was overcome by modifying the technique by placing customized vaginal packing (VP) alongside a standard RR blade based on the patient specific spacial constraints to supplement the rectum displacement. The paper compares the modified technique with the conventional technique of using RR alone on the International Commission on Radiation Units and Measurements-38 (ICRU-38) rectum and bladder point doses.

Potentially toxic metal contamination in semi-arid agricultural soils: sources, risk analysis, and spatial distribution.

The increased demand, driven by a growing population and changing dietary habits, has created immense pressure on agroecosystems throughout the globe. In semi-arid areas, this increased pressure has led to excessive use of agrochemicals in agriculture, which poses a threat of potentially toxic metal (PTM) contamination in agricultural soils. PTMs in agricultural soils result in significant environmental and health threats for humans and livestock.

Chemical composition and antifungal activity of rhizomatous essential oil of cultivated Edgew.: an endangered and medicinally valuable plant species of Northwest Himalayas.

Essential oil extracted from roots is used in various ailments. The plant is cultivated but the composition of essential oil varies from wild plants. The essential oil composition has been studied by using hydro-distillation extraction method and GC-MS analysis.

Intriguing Cases of Diffuse Large B Cell Lymphoma in Paranasal Sinuses with Review of Literature.

Diffuse Large B-Cell Lymphoma (DLBCL) of the paranasal sinuses (PNS) is an uncommon manifestation of non-Hodgkin lymphoma (NHL), accounting for 0.2-2% of all DLBCL cases. Despite DLBCL being the most frequent subtype of NHL, its occurrence in the PNS is rare, often leading to diagnostic delays due to nonspecific symptoms.

Molecular weight determination by Chromatography and Viscometry: A case study using novel polysaccharide of Eupatorium adenophorum L.

Molecular weight analysis of natural polysaccharides is necessary for diverse nutraceutical, pharmaceutical, biological, chemical and other industrial applications. The present study focuses on the determination of the molecular weight of polysaccharide from Eupatorium adenophorum using HP-GPC and Viscometry independently, apart from the chemical composition of constituent monosaccharides. The novel polysaccharide was isolated from leaves of the species, followed by purification using repetitive precipitation, centrifugation, dialysis and chromatographic purification to obtain the polysaccharide in 0.

Cardioneural Ablation for Functional Bradycardia and Vasovagal Syncope: Outcomes From the U.S. Multicenter CNA Registry.

Background: Cardioneural ablation (CNA) shows promise as a viable alternative to permanent cardiac pacing and pharmacotherapy for patients with symptomatic functional bradycardia and debilitating vasovagal syncope (VVS). The evidence supporting a potential therapeutic role for CNA is limited by relatively small sample sizes from predominantly single-center reports.

Objectives: This study sought to report the feasibility, safety, and clinical efficacy of CNA from a large, first-ever multicenter US registry.

Conundrum of station 13 lymph nodes in Gallbladder Carcinoma: Retrospective tryst with a forgotten entity.

Gallbladder cancers are one of the lethal cancers with dismal prognosis. There is discrepancy between various biliary societies regarding extent of regional lymph nodes of gallbladder. Some consider station 13 as regional nodes, whereas others consider it as distant metastatic node.

Spatial disparities in death registration across states and districts of India, 2019-21.

Background: The persistent issue of incomplete death registration in India, with a significant number of deaths going unrecorded, underscores the critical need for a granular understanding of spatial variations. Given the nation's vast geographic and demographic diversity, this granular understanding, particularly at the district level, is crucial for effective interventions. This analysis, therefore, aims to examine spatial disparities in death registration at both the state and district levels across India.

Recent Advancements in Rubber Composites for Physical Activity Monitoring Sensors: A Critical Review.

This review provides the latest insight (2020 to 2025) for composite-based physical activity monitoring sensors. These composite materials are based on carbon-reinforced silicone rubber. These composites feature the use of composite materials, thereby allowing the creation of new generation non-invasive sensors for monitoring of sports activity.

Genomic introgression and expression profiling of the KTI null allele in soybean through elite-by-elite backcrossing.

Soybean stands out with a high protein (35-45 %) and oil content (18-22 %) is one of the important plant-based protein sources. However, the presence of Kunitz Trypsin Inhibitor (KTI), an anti-nutritional factor, reduces the bioavailability of soybean proteins. While thermal inactivation of KTI is possible, it compromises protein solubility and leaves residual activity.

Robust Composites Based on Silicone Rubber for Self-Powered Piezoelectric Nanogenerators.

Obtaining robust power density through piezoelectric nanogenerators (PENGs) is very challenging. Challenges include achieving good mechanical stability, optimum stiffness, reasonable voltage generation, limited heat dissipation, and power density as needed. This work focused exactly on these areas, and hybrid filler emerged as a promising candidate among the composites studied.

Immunohistochemical expression of PDL1 and Ki67 in glioma and its correlation with treatment and overall survival.

Context: Gliomas are the most common primary brain tumors with an infiltrative nature; hence, complete removal is difficult, and despite radiotherapy and chemotherapy, there have been a high recurrence and poor survival rates. Hence, novel therapeutic strategies are needed to reduce recurrence and improve prognosis. Programmed death cell ligand (PD-L1) is a major prognostic biomarker for immune therapy in many cancers by using anti-PD-L1 antibodies.

Utilization of full antenatal care among Scheduled Caste mothers in India, 2015-2021.

Background: Despite the well-documented benefits of full ANC- which includes at least four visits starting in the first trimester, two or more tetanus shots, and over 100 days of iron-folic acid (IFA) supplementation coverage remains alarmingly low, particularly among socioeconomically disadvantaged Scheduled Caste (SC) mothers. However, there is a dearth of research focusing specifically on this population. Therefore, this study aims to investigate the change in the coverage of full ANC and its determinants among SC mothers in India.