Preliminary Findings on Post-COVID Cardiovascular Risk: Transcriptional Regulation and Gene Expression Patterns.

Survivors of COVID-19 are facing a new vulnerability of encountering post-COVID complications, including cardiovascular diseases (CVDs). Despite the increasing prevalence of CVDs, post-COVID-induced cardiac abnormalities significantly escalate mortality and morbidity. However, some recent studies have begun to elucidate complex pathological signaling pathways in these conditions, further investigation is required to distinguish key genetic and proteomic regulators in post-COVID states precisely.

Efficacy of 'Triple Therapy' in Eradicating Ulcer Related Helicobacter pylori Infection at a Tertiary Hospital in Fiji-A Pilot Study.

Background: Fiji currently uses a seven-day Clarithromycin based triple therapy regimen for Heliobacter pylori (H. pylori) eradication, and the local eradication rate is unknown. H.

Imaging Characteristics and Radiological Analysis of Rhinoorbital - Cerebral Mucormycosis.

Objective: To demonstrate the usefulness of magnetic resonance imaging (MRI) in diagnosing important imaging findings in rhino-orbito-cerebral mucormycosis.

Materials And Methods: This is a retrospective cross-sectional study conducted at three medical colleges over 1 month in the patients diagnosed with coronavirus disease 2019 (COVID-19) and who developed mucormycosis of the paranasal sinuses during the treatment and in the post-recovery phase.

Results: A total of 95 patients with male preponderance presented with mucormycosis.

Integrated insights into gene expression dynamics and transcription factor roles in diabetic and diabetic-infectious wound healing using rat model.

Background: Diabetic or diabetic infectious wounds pose a global challenge, marked by delayed healing and high amputation/mortality rates. This study of participating transcriptomes and their regulators unveils critical alterations.

Methods: Transcriptome data from GEO analyzed DEGs in diabetic foot ulcers vs.

Prospective Observational Study of De-Escalation of Empirical Antibiotics in Fiji's National Hospital.

Antimicrobial resistance is a global health threat and Fiji is not exempt. The appropriate prescribing and timely de-escalation of antibiotics as an integral component of antimicrobial stewardship has been recently introduced in Fiji to help curb antimicrobial resistance through de-escalation, leading to a reduced opportunity for the induction of resistance. To assess whether empirical antibiotics are being adjusted in a timely fashion in patients admitted with a diagnosis of suspected infection in the Colonial War Memorial Hospital( CMWH) over three months.

Tunable photo-response in the visible to NIR spectrum range of Germanium-based junctionless nanowire transistor.

In this paper, the phototransistor behavior is investigated in the germanium-on-insulator (GeOI)-based junctionless nanowire (JL-NW) transistor under various light conditions. High responsivity and photosensitivity are attributed in the fully depleted regime within the visible and near-infrared bands. The impact of light is also investigated in detail on the electronic and transfer characteristics such as energy bandgap, carrier distribution, electrostatic potential, electric field, generation and recombination rates.

Validating the temporal performance of genetic biomarkers in an animal model of recurrence/ non-recurrence myocardial infarction persuades by bioinformatics tools.

With a global towering prevalence of index acute myocardial infarction (nonrecurrent MI, NR-MI), a high incidence of recurrent MI (R-MI) has emerged in recent decades. Despite the extensive occurrence, the promising predictors of R-MI have been elusive within the cohort of survivors. This study investigates and validates the involvement of distinct gene expressions in R-MI and NR-MI.

Size-induced exchange bias in single-phase CoO nanoparticles.

The tuning of exchange bias (EB) in nanoparticles has garnered significant attention due to its diverse range of applications. Here, we demonstrate EB in single-phase CoO nanoparticles, where two magnetic phases naturally emerge as the crystallite size decreases from 34.6 ± 0.

Integrative experimental validation of concomitant miRNAs and transcription factors with differentially expressed genes in acute myocardial infarction.

Identification of concomitant miRNAs and transcription factors (TFs) with differential expression (DEGs) in MI is crucial for understanding holistic gene regulation, identifying key regulators, and precision in biomarker and therapeutic target discovery. We performed a comprehensive analysis using Affymetrix microarray data, advanced bioinformatic tools, and experimental validation to explore potential biomarkers associated with human pathology. The search strategy includes the identification of the GSE83500 dataset, comprising gene expression profiles from aortic wall punch biopsies of MI and non-MI patients, which were used in the present study.

Amelioration of endothelial integrity by 3,5,4'-trihydroxy-trans-stilbene against high-fat-diet-induced obesity and -associated vasculopathy and myocardial infarction in rats, targeting TLR4/MyD88/NF-κB/iNOS signaling cascade.

Exacerbated expression of TLR4 protein (foremost pattern recognition receptor) during obesity could trigger NF-κB/iNOS signaling through linker protein (MyD88), predisposed to an indispensable inflammatory response. The induction of this detrimental cascade leads to myocardial and vascular abnormalities. Molecular docking was studied for protein-ligand interaction between these potential targets and resveratrol.

Antiarthritic Activity and Inflammatory Mediators Modulation Effect of Traditional Ajmodadi Churna on Arthritis Experimental Model.

Objectives: The study was designed to evaluate anti-arthritic activity of Ajmodadi Churna (AC) and its effect on Complete freund's adjuvant (CFA)-induced arthritis in Wistar rats.

Methods: Arthritis was induced by injecting 0.2 mL CFA into sub plantar surface of left hind paw.

Surface engineering of colloidal quaternary chalcogenide CuZnSnS nanocrystals: a potential low-cost photocatalyst for water remediation.

Colloidal route synthesis of quaternary compound CZTS (CuZnSnS) has been anticipated with an inimitable combination of coordinating ligands and solvents using the hot injection technique. CZTS is recognized as one of the worthiest materials for photo-voltaic/catalytic applications due to its exclusive properties (viz., non-toxic, economical, direct bandgap, high absorbance coefficient, etc.

Arthrocentesis Followed by Autologous Blood Injection in the Treatment of Chronic Symptomatic Subluxation of Temporomandibular Joint.

Introduction: Temporomandibular joint subluxation is defined as self-reducing partial dislocation of the TMJ during which the condyle passes anterior to the articular eminence.

Material And Method: The study consisted of 30 patients, 19 females and 11 males with 14 unilateral and 16 bilateral cases of chronic symptomatic subluxation. Treatment consisted of arthrocentesis followed by 2 ml of autologous blood injection into upper joint space and 1 ml into pericapsular tissues using an autoclaved soldered double needle with single puncture technique.

Treatment Pattern and Outcomes in Verrucous Carcinoma of Oral Cavity: A Single Institutional Retrospective Analysis from a Tertiary Cancer Center and Review of Literature.

Verrucous carcinoma (VC) is a locally invasive uncommon histopathological variant of oral squamous cell cancer. There is paucity of literature regarding control rates in these cases. We intend to report the outcomes in terms of administered treatment and control rates.

Prevalence and Risk Factors of Hypertension among Police Personnel of District Gwalior- A Cross Sectional Study.

Context: Hypertension is an emerging public health problem due to its high prevalence and association with cardiovascular and overall morbidity and mortality. Police personnel constitute a special occupational group with exposure to violence and stress at work, which affects their health directly and indirectly.

Methodology: A cross-sectional study was conducted to find out the prevalence of hypertension and its relation with respect to police duty profile along with other risk factors among the police personnel of the Gwalior district stationed at various police stations.

Metal to insulator transition, colossal Seebeck coefficient and large violation of Wiedemann-Franz law in nanoscale granular nickel.

We report on the electrical and thermal transport properties of nickel nanoparticles with crystallite size from 23.1 ± 0.3 to 1.

Mediating effect of industry 4.0 technologies on the supply chain management practices and supply chain performance.

The ever-growing concern of sustainability and survivability attracts academicians and practitioners to develop strategies and supply chain capabilities that cater to the challenges and helps in achieving the sustainability development goals. There is a need to develop a holistic model that facilitates understanding the relationships among supply chain practices, industry 4.0 technologies, and supply chain performance measures.

Elements and Performance Indicators of Integrated Healthcare Programmes on Chronic Diseases in Six Countries in the Asia-Pacific Region: A Scoping Review.

Background And Aims: Globally, hospital-based healthcare models targeting acute care, are not effective in addressing chronic conditions. Integrated care programmes for chronic diseases have been widely developed and implemented in Europe and North America and to a much lesser extent in the Asia-Pacific region to meet such challenges. We completed a scoping review aiming to examine the elements of programmes identified in the literature from select study countries in the Asia-Pacific, and discuss important facilitators and barriers for design and implementation.

Ultralow Thermal Conductivity and Large Figure of Merit in Low-Cost and Nontoxic Core-Shell Cu@CuO Nanocomposites.

Identification of novel materials with enhanced thermoelectric (TE) performance is critical for advancing TE research. In this direction, this is the first report on TE properties of low-cost, nontoxic, and abundant core-shell Cu@CuO nanocomposites synthesized using a facile and cheap solution-phase method. They show ultralow thermal conductivity of nearly 10 of the copper bulk value, large thermopower of ∼373 μVK, and, consequently, a TE figure of merit of 0.

Quercetin accelerated cutaneous wound healing in rats by modulation of different cytokines and growth factors.

Quercetin on wounds could be favorable for healing based on its variety of biological effects. Eighty wounded rats were divided into four groups i.e.