PRMT5 activity sustains histone production to maintain genome integrity.

Histone proteins package DNA into nucleosomes, forming chromatin and thereby safeguarding genome integrity. Proper histone expression is essential for cell proliferation and chromatin organization, yet the upstream regulators of histone supply remain incompletely understood. PRMT5-a cell essential type II protein arginine methyltransferase frequently overexpressed in cancer-catalyzes symmetric dimethylation of arginine residues.

Posterior Tracheal Wall Laceration Following Tracheostomy: A Progressive Nightmare Under Long-Term Ventilation, Requiring Complex Repair With vvECMO Support-A Case Report.

Untreated tracheal membrane laceration (TML) may have life-threatening consequences. We present a case of untreated TML during or after tracheostomy. Air leakage along the cannula after tracheostomy was treated with raising cuff pressure up to > 100 mmHg and enlarging the tracheal lumen in the area of TML.

Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2-mutated post-MPN AML.

Acute myeloid leukemia (AML) that evolves from myeloproliferative neoplasm (MPN) is known as post-MPN AML. Current treatments do not significantly extend survival beyond 12 months. B-cell lymphoma-extra large (BCL-xL) has been found to be overexpressed in leucocytes from patients with MPN, making it a potential therapeutic target.

U2-2 snRNA Mutations Alter the Transcriptome.

Unlabelled: Intron removal from pre-mRNA is catalyzed by the spliceosome, which comprises 5 snRNPs containing small nuclear RNAs (snRNAs). U2 snRNA makes critical RNA-RNA and RNA-protein contacts throughout the splicing cycle. Mutations in U2 snRNA, particularly at position C28, have been linked to cancers.

Correction: .

[This corrects the article DOI: 10.1007/s13755-024-00316-4.].

Zinner syndrome: A mesonephric duct anomaly with renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction.

Anomalies of the mesonephric duct are associated with a combination of renal agenesis/dysgenesis, ejaculatory duct obstruction, and seminal vesical cyst, called Zinner syndrome. We present a case of this rare syndrome in a young male patient, who initially presented with urinary symptoms. The relevant embryology and diagnostic modalities are discussed.

Smoking-Associated Carcinogen-Induced Inflammation Promotes Lung Carcinogenesis via IRAK4 Activation.

Purpose: Even though smoking is associated with lung cancer, the exact molecular pathways that link carcinogens with inflammation and oncogenic transformation are not well elucidated. Two major carcinogens in cigarette smoke, nicotine-derived nitrosamine ketone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo(α)pyrene (BaP), have not been tested in models that mimic inhaled exposure for prolonged periods of time.

Experimental Design: Mouse models were used for intratracheal delivery of NNK and BaP (NB) for 18 months.

Margin-aware optimized contrastive learning for enhanced self-supervised histopathological image classification.

Histopathological images, characterized by their high resolution and intricate cellular structures, present unique challenges for automated analysis. Traditional supervised learning-based methods often rely on extensive labeled datasets, which are labour-intensive and expensive. In learning representations, self-supervised learning techniques have shown promising outcomes directly from raw image data without manual annotations.

Understanding and Controlling Structural Defects and Disordering in LiNiMnO Cathodes for Direct Recycling.

Despite significant progress in recycling spent lithium-ion batteries (LIBs), nondestructive, direct recycling methods still face untenable discrepancies in multiple cathode chemistries, which primarily originate from a variety of structure stabilities during the recycling process. Through systematic investigation of the microstructure evolution during the relithiation treatment, we observed the inevitably induced defects and Li/Mn disordering in the LiNiMnO cathode, contributing to the sluggish Li transport and irreversible capacity loss. Employing a defect engineering approach to achieve twin boundaries and preferred grain orientation, we show the regenerated cathodes demonstrate a substantial enhancement of Li diffusion and cycling stability, retaining 97.

Multifunctional Scavenger Boosts Cathode Interfacial Stability with Reduced Water Footprint for Direct Recycling of Spent Lithium-Ion Batteries.

The burgeoning accumulation of spent lithium-ion batteries (LIBs), a byproduct from the widespread adoption of portable electronics and electric vehicles, necessitates efficient recycling strategies. Direct recycling represents a promising strategy to maximize the value of LIB waste and minimize harmful environmental outcomes. However, current efforts to large-scale direct recycling face challenges stemming from heterophase residues (e.

Production, purification and characterization of phytase from Pichia kudriavevii FSMP-Y17and its application in layers feed.

Introduction: Phytase, recognized for its ability to enhance the nutritional value of phytate-rich foods, has has gained significant prominence. The production of this enzyme has been significantly boosted while preserving economic efficiency by utilizing natural substrates and optimizing essential factors. This study focuses on optimizing phytase production through solid-state fermentation and evaluating its effectiveness in enhancing nutrient utilization in chicken diets.

Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB.

Protein Arginine Methyltransferase 5 (PRMT5) regulates RNA splicing and transcription by symmetric dimethylation of arginine residues (Rme2s/SDMA) in many RNA binding proteins. However, the mechanism by which PRMT5 couples splicing to transcriptional output is unknown. Here, we demonstrate that a major function of PRMT5 activity is to promote chromatin escape of a novel, large class of mRNAs that we term Genomically Retained Incompletely Processed Polyadenylated Transcripts (GRIPPs).

Enhancing bug allocation in software development: a multi-criteria approach using fuzzy logic and evolutionary algorithms.

A bug tracking system (BTS) is a comprehensive data source for data-driven decision-making. Its various bug attributes can identify a BTS with ease. It results in unlabeled, fuzzy, and noisy bug reporting because some of these parameters, including severity and priority, are subjective and are instead chosen by the user's or developer's intuition rather than by adhering to a formal framework.

Electrospun polarity-controlled molecular orientation for synergistic performance of an artifact-free piezoelectric anisotropic sensor.

Anisotropy in mechanical, optical and thermal sensors in a spatial direction has many applications in health care, robotics, aerospace, and tissue engineering. In particular, wearable and implantable sensors respond to stretching and bending strains that probe mechanical energy and track physiological signals. Hence, the development of anisotropic pressure sensors with true piezoelectric (PE) signals is of utmost importance to achieve efficient devices.

On-Demand MXene-Coupled Pyroelectricity for Advanced Breathing Sensors and IR Data Receivers.

MXene-inspired two-dimensional (2D) materials like TiCT are widely known for their versatile properties, including surface plasmon, higher electrical conductivity, exceptional in-plane tensile strength, EMI shielding, and IR thermal properties. The MXene nanosheets coupled poly(vinylidene fluoride) (PVDF) nanofibers with ∼-26 pm V are able to capture the smaller thermal fluctuation due to a superior pyroelectric coefficient of ∼130 nC m K with an improved (∼7 times with respect to neat PVDF nanofibers) pyroelectric current figure of merit (FOM). The significant enhancement of the pyroelectric response is attributed to the confinement effect of 2D MXene (TiCT) nanosheets within PVDF nanofibers, as evidenced from polarized Fourier transform infrared (FTIR) spectroscopy and scanning probe microscopy (SPM).

Study protocol for factors influencing the adoption of ChatGPT technology by startups: Perceptions and attitudes of entrepreneurs.

Background: Generative Artificial Intelligence (AI) technology, for instance Chat Generative Pre-trained Transformer (ChatGPT), is continuously evolving, and its userbase is growing. These technologies are now being experimented by the businesses to leverage their potential and minimise their risks in business operations. The continuous adoption of the emerging Generative AI technologies will help startups gain more and more experience with adoptions, helping them to leverage continuously evolving technological innovation landscape.

Partially Ion-Paired Solvation Structure Design for Lithium-Sulfur Batteries under Extreme Operating Conditions.

Achieving increased energy density under extreme operating conditions remains a major challenge in rechargeable batteries. Herein, we demonstrate an all-fluorinated ester-based electrolyte comprising partially fluorinated carboxylate and carbonate esters. This electrolyte exhibits temperature-resilient physicochemical properties and moderate ion-paired solvation, leading to a half solvent-separated and half contact-ion pair in a sole electrolyte.

Effect of Electrolyte Chemistry and Sulfur Content in Li||Sulfurized Polyacrylonitrile (SPAN) Batteries.

Sulfurized polyacrylonitrile (SPAN) is considered as a high-value cathode material, which leverages the high energy of S redox while mitigating the negative externalities that limit elemental S cycling. As such, the sulfur content in Li-SPAN batteries plays a critical role. In this work, we demonstrate that high-S loading SPAN cathodes, where the PAN backbone approaches the saturation point without signs of elemental S, are highly dependent on the electrolyte chemistry for long-term reversibility.

Red Cell Distribution Width and Ratio of Red Cell Distribution Width-to-Total Serum Calcium as Predictors of Outcome of Acute Pancreatitis.

Background: Current severity assessment scores of acute pancreatitis (AP) include multiple variables, the results of which are available only after 48 h of admission. Red cell distribution width (RDW) and total serum calcium (TSC) are simple routine parameters related to inflammatory status and results of which are readily available.

Aim: The aim of this study was to evaluate RDW and RDW: TSC within 24 h of hospital admission as predictors of outcome (severity and mortality) and intervention (medical/percutaneous drainage/surgical) required by patients of AP.

Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain.

Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain.

Appendicitis Inflammatory Response Score in Acute Appendicitis: A Study at a Tertiary Care Center in North India.

Introduction: Appendicitis is a common cause of acute abdominal pain. The diagnosis is eminently clinical and the cause is surgically correctable. However, a decision of surgery based on the clinical presentation only has a 15%-30% chance of the removal of a normal appendix.

A novel value-based multi-criteria decision making approach to evaluate new technology adoption in SMEs.

The modern competition is moving quickly toward incorporating cutting-edge technological improvements to support Small and Medium Enterprises (SMEs) in enhancing their business models. Making decisions regarding implementing new technologies in SMEs is a challenging process driven by the continuous new advances in the technology industry. Important operational process decisions, such as organizational investment costs, technology acquisition, maintenance, customer experience, employee training for the proper use of each technology, reliability requirements, and security needs, must be made very carefully for such adoptions.