Assessment of Lung Function and Its Correlation With Iron Overload in Children With Thalassemia Major.

Introduction:  Thalassemia major is a genetic disorder characterised by defective red cell production. Due to the requirement of regular blood transfusions, these patients are at risk of iron overload, leading to iron deposition in all organs, including the lungs, causing hemosiderosis of the lung, thereby causing impairment of lung function.

Objectives: The primary objective was to assess lung dysfunction in children with thalassemia major and to correlate it with serum iron status.

Serum Procalcitonin as a Diagnostic and Prognostic Marker in Children With Severe Bacterial Infection: A Prospective Observational Study.

Background: Early recognition of severe bacterial infection (SBI) in children is critical, yet traditional markers such as C‑reactive protein (CRP) lack adequate accuracy. Serum procalcitonin (PCT) rises rapidly after bacterial insult and may offer both diagnostic and prognostic value.

Objectives: To compare the diagnostic and prognostic performance of day 1 PCT with CRP in children with suspected SBI at a tertiary center in eastern India.

Dengue Disease Severity in Pediatric Patients With Different Blood Groups: A Study at a Tertiary Care Hospital in Jharkhand.

Background: Dengue fever (DF) is a serious public health concern, especially in tropical regions like India. Cases cluster during the monsoon season due to the proliferation of Aedes mosquitoes, significantly burdening public health and the economy. In addition to prevention and control, identifying risk factors that provide early indications of progression to severe forms of the disease can help in prognostication and improve case management.

A Cross-Sectional Study on the Observation of Clinical Profiles and Associated Electrolyte Disturbances in Patients Admitted to the Pediatric Intensive Care Unit (PICU) at a Tertiary Care Center.

Objective: This study aims to determine the prevalence of electrolyte disturbances in children hospitalized in the pediatric intensive care unit (PICU) of Rajendra Institute of Medical Sciences (RIMS), a tertiary care center in Ranchi, India, and to evaluate related factors like pneumonia, heart disease, meningitis/encephalitis, and others.

Methods: Serum electrolyte levels (sodium, potassium, calcium, magnesium) were obtained from 110 patients admitted to the PICU at RIMS. Statistical analyses were conducted to identify the prevalence and association of disturbances with specific diseases.

Prevalence of Malaria among Apparently Healthy Blood Donors at Tertiary Health-care Center in Northeastern Tribal Region of India.

Background: Transfusion Transmitted Malaria is a major concern among blood donors in endemic countries. The Drugs and Cosmetic Act 1940 in India mandated testing of all blood donations for Malaria. Regular screening of malaria prevents severe transfusion-transmitted malaria, and shows its prevalence and enables its control among the population.

Navigating herpes simplex encephalitis: Family medicine perspectives from Jharkhand, India.

Background: Herpes simplex encephalitis (HSE), caused by herpes simplex virus (HSV) is the most common cause of sporadic encephalitis that often presents as an emergency case of acute or sub-acute nature associated with poor prognosis. Early suspicion and prompt diagnostic testing with adequate antiviral therapy can only reduce morbidity and mortality associated with the disease. This study aims to evaluate the role of serological and molecular diagnosis of encephalitis caused by HSV 1 and 2 for timely detection of the disease.

A Rare Case of Juvenile Systemic Sclerosis With Concurrent Disseminated Tuberculosis: Diagnostic and Therapeutic Challenges.

We present the case of a 13-year-old female diagnosed with juvenile systemic sclerosis, diffuse cutaneous subtype, along with active disseminated tuberculosis. This co-occurrence poses unique diagnostic and therapeutic challenges, particularly given the risk of tuberculosis exacerbation due to immunosuppressive therapy required for systemic sclerosis. The patient had signs/symptoms like progressive skin tightening and Raynaud's phenomenon; the diagnosis was confirmed by the presence of anti-Scl-70 antibodies.

Comparison of Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) and the Level of Cortisol Between Preterm and Term Newborns.

Introduction According to the thrifty (Barker's) phenotype hypothesis, poor nutrition in fetal and early infancy plays a role in the development and function of the beta cells of the islets of Langerhans, which leads to the development of type 2 diabetes mellitus. Insulin resistance is due to decreased suppressive effect of insulin on hepatic glucose production. Thus, elevated insulin levels during perinatal life may predispose the infant to the development of diabetes mellitus in future life.

To study thyroid hormone levels (FT3, FT4, and TSH levels) in critically ill children and their correlation with disease severity and clinical outcome in Rajendra Institute of Medical Sciences, Ranchi, Jharkhand.

Introduction: There are manifold effects on neuro-endocrine and metabolic systems due to critical illness. Abnormalities in thyroid hormone levels in a critically-ill patient with no pre-existing hypothalamo-pituitary-thyroid dysfunction is seen in Euthyroid sick syndrome or Non thyroidal illness syndrome. The understanding of different endocrinal changes in acute phase of critical illness may help us to intervene early and improve by pharmacological intervention.