Bereavement and maternal mental disorders during the perinatal period: a nationwide register-based study in Sweden.

Perinatal mental disorders are common, yet few robust risk factors are known. Stressful life events such as loss of a close family member due to death could serve as potential clinical predictors for which mothers develop perinatal mental disorders. This study investigated the association between bereavement and the risk of first-onset perinatal mental disorders.

Comorbidity patterns associated with severe COVID-19 outcomes: A cohort study based on the UK Biobank.

Background: Pre-existing comorbidities are linked to increased risk of severe COVID-19, but comprehensive assessments of comorbidity patterns remain limited.

Methods: We used network analysis to identify pre-existing comorbidity modules (i.e.

Gender, care-seeking behavior, and adverse mental health during the first year of the COVID-19 pandemic in sweden: an exploratory study.

This exploratory study aimed to examine whether gender and care-seeking behaviors were associated with the frequency of adverse mental health symptoms during the COVID-19 pandemic based on the longitudinal Omtanke2020 Study in Sweden (N = 27,562). The study was performed using self-reported data from adult volunteers through online surveys. Descriptive network analysis was used to explore the cross-sectional relationships between gender, care-seeking behavior, and symptoms of depression, anxiety, and COVID-19-related distress at baseline as well as 6-month and 12-month follow-ups.

Disease clusters and their genetic determinants following a diagnosis of depression: analyses based on a novel three-dimensional disease network approach.

Depression is strongly associated with a range of subsequent diseases. To elucidate key mechanistic pathways for targeted interventions, this study aimed to determine the main disease networks associated with depression as well as their underlying genetic determinants. We developed a novel three-dimensional network approach which refines disease association verification by incorporating regularized partial correlations, and facilitates robust identification and visualization of disease clusters (i.

Premenstrual disorders and risk of cardiovascular diseases.

Several lines of evidence indicate a potential link between premenstrual disorders (PMDs) and cardiovascular diseases (CVDs). However, it remains unclear whether women with PMDs have a higher risk of CVDs. Here we present a Swedish nationwide population-based matched cohort study from 2001 to 2022 and a sibling matched cohort to address familial confounding.

Stress Resilience and Risk of Psychiatric Disorders After Childhood Bereavement.

Importance: Childhood bereavement increases the risk of common psychiatric disorders later in life. However, the role of stress resilience in this association remains underexplored.

Objective: To assess whether stress resilience mediates the association between childhood bereavement and psychiatric disorder risk in adulthood.

Premenstrual disorders and risk of sick leave and unemployment: a prospective cohort study of 15 857 women in Sweden.

Background: Premenstrual disorders (PMDs) are prevalent and impair women's quality of life, but their long-term influence on work capacity is unclear. Understanding the association between PMDs and subsequent sick leave and unemployment could inform interventions and policies.

Objective: We hypothesised that women with PMDs have an increased risk of future sick leave and unemployment compared with those without PMDs.

Adverse childhood experiences and prevalence of type 2 diabetes in a nationwide study of women.

We aimed to examine the association between adverse childhood experiences (ACEs) and type 2 diabetes in a nationwide cohort of Icelandic women, and to assess the mechanisms through which it is mediated. We used cross-sectional data from the nationwide-representative Stress-And-Gene-Analysis cohort, including 26 952 Icelandic women aged 18-69 years who self-reported exposure to 13 types of ACEs and adult diagnosis of type 2 diabetes. Modified Poisson regression was used to quantify the association between ACEs and type 2 diabetes, adjusting for age and childhood deprivation.

Association of Polygenic Risk for Psychiatric Disorders with Cardiometabolic Disease.

Importance: Clinical diagnoses of psychiatric disorders are associated with cardiometabolic diseases (CMDs) such as type 2 diabetes and ischemic heart diseases. Studying how genetic liability for psychiatric disorders relate to CMD risk will offer novel insight into the relationship between psychiatric disorders and CMDs.

Objective: To evaluate the associations between psychiatric polygenic risk scores (PRSs) and clinically diagnosed CMDs while accounting for cross-disorder pleiotropy.

Adverse childhood experiences, mental distress, and autoimmune disease in adult women: findings from two large cohort studies.

Background: Adverse childhood experiences (ACEs) have been associated with increased risks of autoimmune diseases. However, data are scarce on the role of specific ACEs as well as the potential mediating role of adverse mental health symptoms in this association.

Methods: A cohort study using the nationwide Icelandic Stress-And-Gene-Analysis (SAGA, 22,423 women) cohort and the UK Biobank (UKB, 86,492 women) was conducted.

Sex differences in clinically diagnosed psychiatric disorders over the lifespan: a nationwide register-based study in Sweden.

Background: Limited studies exist on sex differences in incidence rates of psychiatric disorders across the lifespan. This study aims to analyze sex differences in the incidence rates of clinically diagnosed psychiatric disorders over the lifespan.

Methods: We conducted a nationwide register-based cohort study, including all individuals who were born in Sweden and lived in Sweden between 2003 and 2019, including 4,818,071 females and 4,837,829 males.

Prevalence of Life Stressors and Posttraumatic Stress Disorder Among Women in Iceland.

Importance: Comprehensive data on the prevalence of various life stressors and their role in posttraumatic stress disorder (PTSD) among women are lacking.

Objective: To determine the prevalence of a broad range of life stressors and their association with PTSD in a large nationally representative cohort of women.

Design, Setting, And Participants: This cross-sectional analysis used data from the population-based Stress-And-Gene-Analysis, which invited women in Iceland to complete an online survey from March 1, 2018, to July 1, 2019.

Inflammatory Biomarkers and Risk of Psychiatric Disorders.

Importance: Individuals with psychiatric disorders have been reported to have elevated levels of inflammatory biomarkers, and prospective evidence is limited regarding the association between inflammatory biomarkers and subsequent psychiatric disorders risk.

Objective: To assess the associations between inflammation biomarkers and subsequent psychiatric disorders risk.

Design, Setting, And Participants: This was a prospective cohort study including individuals from the Swedish Apolipoprotein Mortality Risk (AMORIS) cohort, with no prior psychiatric diagnoses and having a measurement of at least 1 inflammatory biomarker.

Association between severe premenstrual disorders and change of romantic relationship: A prospective cohort of 15,606 women in Sweden.

Background: Premenstrual disorders (PMDs) affect women's quality of life, yet the impact on romantic relationships remains unclear. This study aimed to examine the association between severe PMDs and relationship disruption and initiation.

Methods: We conducted a prospective cohort study of 15,606 women during 2009-2021 in Sweden.

Perinatal depression and risk of maternal cardiovascular disease: a Swedish nationwide study.

Background And Aims: Increasing evidence suggests that some reproductive factors/hazards are associated with a future risk of cardiovascular disease (CVD) in women. While major (non-perinatal) depression has consistently been associated with CVD, the long-term risk of CVD after perinatal depression (PND) is largely unknown.

Methods: A nationwide population-based matched cohort study involving 55 539 women diagnosed with PND during 2001-14 in Sweden and 545 567 unaffected women individually matched on age and year of conception/delivery was conducted.

Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians.

Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders.

Sexual violence in the workplace and associated health outcomes: a nationwide, cross-sectional analysis of women in Iceland.

Background: Workplace sexual violence against women is a pressing global issue with scarce knowledge on its health implications. Existing research is largely limited to specific occupations, which calls for comprehensive, population-based studies. This study aimed to examine the associations between self-labelled workplace sexual violence and a variety of health outcomes in a nationally representative sample of Icelandic women aged 18-69 years.

Mortality Risk Among Women With Premenstrual Disorders in Sweden.

Importance: Premenstrual disorders (PMDs) adversely affect the quality of life of millions of women worldwide, yet research on the long-term consequences of PMDs is limited, and the risk of mortality has not been explored.

Objective: To estimate the associations of PMDs with overall and cause-specific mortality.

Design, Setting, And Participants: This nationwide, population-based, matched cohort study used data from population and health registers in Sweden.

Association of pre-existing depression and anxiety with Omicron variant infection.

Pre-existing psychiatric disorders were linked to an increased susceptibility to COVID-19 during the initial outbreak of the pandemic, while evidence during Omicron prevalence is lacking. Leveraging data from two prospective cohorts in China, we identified incident Omicron infections between January 2023 and April 2023. Participants with a self-reported history or self-rated symptoms of depression or anxiety before the Omicron pandemic were considered the exposed group, whereas the others were considered unexposed.

The bidirectional association between premenstrual disorders and perinatal depression: A nationwide register-based study from Sweden.

Background: Premenstrual disorders (PMDs) and perinatal depression (PND) share symptomology and the timing of symptoms of both conditions coincide with natural hormonal fluctuations, which may indicate a shared etiology. Yet, there is a notable absence of prospective data on the potential bidirectional association between these conditions, which is crucial for guiding clinical management. Using the Swedish nationwide registers with prospectively collected data, we aimed to investigate the bidirectional association between PMDs and PND.