System-on-Chip for Flow Cytometry With Impedance Measurement and Integrated Real-Time Size Classification.

This paper presents an impedance measurement system-on-chip (SoC) for flow cytometry (i.e. cell counting) applications.

Microfluidic Lab-on-CMOS Packaging Using Wafer-Level Molding and 3D-Printed Interconnects.

Lab-on-a-chip (LoC) technologies continue to promise lower cost and more accessible platforms for performing biomedical testing in low-cost and disposable form factors. Lab-on-CMOS or lab-on-microchip methods extend this paradigm by merging passive LoC systems with active complementary metal-oxide semiconductor (CMOS) integrated circuits (IC) to enable front-end signal conditioning and digitization immediately next to sensors in fluid channels. However, integrating ICs with microfluidics remains a challenge due to size mismatch and geometric constraints, such as non-planar wirebonds or flip-chip approaches in conflict with planar microfluidics.

A Reconfigurable Tri-Mode Frequency-Locked Loop Readout Circuit for Biosensor Interfaces.

In this article, a frequency-locked loop (FLL) based multimodal readout integrated circuit (IC) for interfacing with off-chip temperature, electrochemical, and pH sensors is presented. By reconfiguring its switched-capacitor feedback network, the readout circuit is able to measure resistance, current, and voltage without additional active analog front-end circuits. A prototype IC was fabricated in a 0.

Wireless, Multi-Sensor System-on-Chip for pH and Amperometry Powered by Body Heat.

This article presents a body-heat-powered, multi-sensor SoC for measurement of chemical and biological sensors. Our approach combines analog front-end sensor interfaces for voltage- (V-to-I) and current-mode (potentiostat) sensors with a relaxation oscillator (RxO) readout scheme targeting << 10 μW power consumption. The design was implemented as a complete sensor readout system-on-chip, including a low-voltage energy harvester compatible with thermoelectric generation and a near-field wireless transmitter.