Frustrated Lewis Pair (FLP) Reactivity from Carbone-BPh Lewis Adduct.

We present a systematic investigation of the Frustrated Lewis Pair (FLP) chemistry of carbodicarbenes (fCDCs) featuring varied steric profiles in combination with strong (B(CF), BCF) and weak (BPh) boron Lewis acids. The resulting CDC-borane systems display a full spectrum of behaviors: (i) tightly bound Lewis adducts lacking FLP reactivity, (ii) adducts exhibiting reversible dissociation and activate small molecules via FLP-type reactivity, and (iii) a "classical" FLP that remain unbound. The most reactive Lewis adduct, 1·BPh, which exhibits the lowest dissociation energy, activates a broad range of bonds (C─H, O─H, N─H, H─B, H─Si, S─S, and CO) and catalyzes hydroboration and hydrosilylation of ketones under mild, metal-free conditions.

Gender Differences in Head and Neck Posture Among Smartphone Users While Walking: Insights from Field Observations in Taipei.

: Despite the increasing prevalence of smartphone use while walking, few studies have comprehensively investigated head and neck posture in real-world settings. This study employed a single-blind observation of smartphone users walking in public areas of Taipei, Taiwan, to examine head and neck movements, with a particular focus on the effects of gender and hand-operation type. : We conducted observations of 120 smartphone users (60 males and 60 females), recording neck flexion (NF), head flexion (HF), gaze angle (GA), and viewing distance (VD) in the sagittal plane during walking.

Modifying the Substrate-Dependent Pd/FeO Catalyst-Support Synergism with ZnO Atomic Layer Deposition.

Low-loading Pd supported on FeO nanoparticles was synthesized. A common nanocatalyst system with previously reported synergistic enhancement of reactivity that is attributed to the electronic interactions between Pd and the FeO support. FeO-selective precoalescence overcoating with ZnO atomic layer deposition (ALD), using Zn(CHCH) and HO as precursors, dampens competitive hydrogenation reactivity at FeO-based sites.

Carbon Nanotubes Induce Mineralization of Human Cementoblasts.

Introduction: Carbon nanotubes (CNT) are 1 of the allotropes of carbon with unique properties. CNT shows good bone-tissue compatibility and has been reported to induce osteogenesis; therefore, it is regarded as an ideal material in a wide range of applications. However, the therapeutic effect of CNT-containing materials in the healing of apical periodontal tissue is unknown.

Role of MAPKs in TGF-β1-induced maturation and mineralization in human osteoblast-like cells.

Objectives: Our study aimed to clarify the role of mitogen-activated protein kinases (MAPKs) in transforming growth factor (TGF)-β1-stimulated mineralization in the human osteoblast-like MG63 cells.

Methods: The viability of MG63 cells under TGF-β1 stimulation was assessed by MTS assay. Western blotting determined TGF-β1-mediated activation of extracellular signal-related protein kinase (ERK), p38, and c-Jun amino-terminal kinase (JNK).

Diversification of the Carbodicarbene Class by Embedding an Anionic Component in its Scaffold.

Carbodicarbene (CDC) has become an emerging ligand in many fields due to its strong σ-donating ability. View Article and Find Full Text PDF

Changes of blood-brain-barrier function and transfer of amyloid beta in rats with collagen-induced arthritis.

Background: Rheumatoid arthritis (RA) is characterized by synovial inflammation, cartilage damage, and systemic inflammation. RA is also associated with the occurrence of neuroinflammation and neurodegenerative diseases. In this study, the impacts of RA on the function of the blood-brain barrier (BBB) and the disposition of amyloid beta (Aβ), including BBB transport and peripheral clearance of Aβ, were investigated in rats with collagen-induced arthritis (CIA), an animal model with similarity to clinical and pathological features of human RA.

EARRINGS: an efficient and accurate adapter trimmer entails no a priori adapter sequences.

Motivation: Cross-sample comparisons or large-scale meta-analyses based on the next generation sequencing (NGS) involve replicable and universal data preprocessing, including removing adapter fragments in contaminated reads (i.e. adapter trimming).

Directing Group-Promoted Inert C-O Bond Activation Using Versatile Boronic Acid as a Coupling Agent.

A simple Ni(cod) and carbene mediated strategy facilitates the efficient catalytic cross-coupling of methoxyarenes with a variety of organoboron reagents. Directing groups facilitate the activation of inert C-O bonds in under-utilized aryl methyl ethers enabling their adaptation for C-C cross-coupling reactions as less toxic surrogates to the ubiquitous haloarenes. The method reported enables C-C cross-coupling with readily available and economical arylboronic acid reagents, which is unprecedented, and compares well with other organoboron reagents with similarly high reactivity.

Flavonoids Identification and Pancreatic Beta-Cell Protective Effect of Lotus Seedpod.

Oxidative stress is highly associated with the development of diabetes mellitus (DM), especially pancreatic beta-cell injury. Flavonoids derived from plants have caused important attention in the prevention or treatment of DM. Lotus seedpod belongs to a traditional Chinese herbal medicine and has been indicated to possess antioxidant, anti-age, anti-glycative, and hepatoprotective activities.

Ligand promoted Pd-catalyzed dehydrogenative alkenylation of hetereoarenes.

An efficient Pd-catalyzed cross-dehydrogenative coupling of heteroarenes with styrenes and other olefinic substrates has been developed. This alkenylation paradigm encompasses a wide range of substrates and provides a straightforward approach toward C2-E-alkenylated azole motifs.