Relationship Between Early Cartilage Degeneration With T1ρ and T2 Analysis in Medial Tibial Cartilage and 10-Year Posttraumatic Osteoarthritis Progression After ACL Reconstruction.

Background: Quantitative magnetic resonance imaging (qMRI), such as T1ρ and T2 mapping, allows for the characterization of the biochemical composition of cartilage and the detection of early degeneration within 1 year after anterior cruciate ligament reconstruction (ACLR). It remains unclear if early imaging biomarkers are associated with the long-term development of posttraumatic osteoarthritis (PTOA).

Hypothesis/purpose: The study aimed to investigate the relationship between qMRI-based evaluation of the medial compartment at baseline and 1 year after ACLR and the knee joint morphological status using 3-dimensional (3D) MRI at a 10-year follow-up.

Correction: Measuring digital health literacy and its associations with determinants and health outcomes in 13 countries.

[This corrects the article DOI: 10.3389/fpubh.2025.

Foraminal [F]FDG uptake on PET/MRI is associated with radiculopathy and symptom reduction after image-guided nerve root block.

Background And Purpose: There is an imperfect correlation between morphological MRI findings and radiating low back pain. Nerve irritation, visualized as glucose hypermetabolism on [F]FDG-PET/MRI, has the potential to identify symptomatic segments. This study aimed to investigate the association of foraminal [F]FDG uptake on PET/MRI, radiological abnormalities and patient outcomes.

Machine learning models for clinical and structural knee osteoarthritis prediction: Recent advancements and future directions.

Machine learning (ML), increasingly used for predictive modeling, has seen rapid growth in osteoarthritis (OA) research over the past decade. This review highlights recent advances in ML model development across four OA outcome domains: clinical, structural (radiographic and MRI-based), and surgical endpoints, each addressing different but interrelated aspects of the disease. For clinical outcomes, ML studies have focused on predicting changes in patient-reported clinical measures (e.

Synovitis mediates cartilage outcomes during weight-loss in knee osteoarthritis - 4-year follow-up data from the Osteoarthritis Initiative.

Objective: Weight loss can modify the progression of osteoarthritis (OA), and this may, in part, be achieved by decreased synovitis, a known accelerator of cartilage degeneration. The purpose of this study was to investigate whether change in synovitis mediates the beneficial effect of weight loss on longitudinal cartilage outcomes.

Method: We analyzed right knees with baseline Kellgren & Lawrence grades 1-3 of 1153 obese and overweight participants of the Osteoarthritis Initiative (OAI) cohort with Whole Organ MRI Scores (WORMS) and semi-quantitative assessment of effusion synovitis and synovial proliferation scores form 3T MRIs at baseline and 48 months.

Microsurgical clipping of a recurrent anterior communicating artery aneurysm following WEB intrasaccular embolization: illustrative case.

Background: The Woven EndoBridge (WEB) embolization system is an endovascularly deployed intrasaccular device that promotes occlusion in cerebrovascular aneurysms through intra-aneurysmal thrombosis. While the safety and efficacy of the WEB device have been well described in the literature, the treatment of recurrent aneurysms after WEB embolization via microsurgical clipping requires further study.

Observations: A 71-year-old female patient with an incidentally discovered anterior communicating artery aneurysm underwent WEB embolization with complete aneurysm occlusion observed on immediate postintervention angiography.

Skeletal Maturity and Age-Related Changes in Immune Cells and Circulatory Factors Impair Large-Scale Bone Regeneration.

Large-scale bone defects require complex surgical procedures to repair, but full restoration of the bone is not guaranteed due to the significant tissue loss involved. In contrast, fractures can frequently be treated with conservative techniques. Particularly, ribs have a remarkable ability to spontaneously regenerate large-scale bone defects.

Bone Remodeling, Not Inflammation, as the Predominant Pathology in Modic Type 1 Lesions of the Lumbar Spine.

Purpose: Lesions of the vertebral endplates (Modic changes) are associated with low back pain (LBP), and different pathological processes, including inflammation, have been proposed as causative. This study aimed to explore the relationship between [18F]FDG uptake (inflammation) and [18F]NaF uptake (bone remodeling) and patient-reported back pain as well as conventional MRI detected endplate changes.

Methods: Participants were selected from an IRB-approved study, creating two arms: [18F]NaF (n = 11) and [18F]FDG (n = 11).

Ultra-processed food consumption is associated with knee osteoarthritis: Data from the Osteoarthritis Initiative.

Objective: To explore the relationship between ultra-processed food (UPF) intake and knee osteoarthritis (KOA)-related imaging and clinical outcomes in men and women.

Design: Osteoarthritis Initiative participants with sufficient dietary and sociodemographic data (n = 4403) were included in this cross-sectional study. UPF was assessed by food frequency questionnaire-based NOVA Classification, categorizing diet according to processing level, with NOVA-4 indicating UPF.

MRI of atypical lipomatous tumor: does contrast help? A multicenter study.

Objective: To compare the diagnostic performance of non-contrast MRI versus MRI with contrast for differentiating atypical lipomatous tumors (ALT) from lipomas.

Materials And Methods: This multicenter retrospective study included subjects with a histopathologic diagnosis of lipoma or ALT and a preoperative MRI study with contrast. An experienced musculoskeletal radiologist reviewed the images in two sessions, the first session with non-contrast only, and the second session, including postcontrast sequences.

Intra-articular Knee Injections and Progression of Knee Osteoarthritis: Data from the Osteoarthritis Initiative.

Background At least 10% of all patients with knee osteoarthritis (OA) undergo treatment with injectable corticosteroids or hyaluronic acid (HA). Although both have been shown to help with symptomatic pain relief, their long-term effects on knee OA progression remain inconclusive. Purpose To investigate the association between intra-articular knee injections, specifically corticosteroids and HA, and OA progression using a detailed whole-joint semiquantitative MRI evaluation and clinical outcomes for a period of 2 years.

Thigh-muscle volume change in response to diet, exercise, and weight-loss in overweight and obese individuals-8-year follow-up data from the Osteoarthritis Initiative.

Objectives: Weight loss is considered an essential treatment component for knee osteoarthritis (OA), but data on weight-loss-associated changes in skeletal muscle is sparse. This study aimed to assess volumetric changes in major thigh muscle groups during weight loss.

Methods: Included in this longitudinal analysis of the Osteoarthritis Initiative were participants who had (a) stable weight (SW) (body mass index (BMI) ± 3%); (b) moderate weight loss (MWL) (5-10% BMI); (c) extensive weight loss (EWL) (> 10%) and available segmentations of thigh muscles on MR imaging for baseline and 8-year follow-up.

Information Extraction from Lumbar Spine MRI Radiology Reports Using GPT4: Accuracy and Benchmarking Against Research-Grade Comprehensive Scoring.

: This study aimed to create a pipeline for standardized data extraction from lumbar-spine MRI radiology reports using a large language model (LLM) and assess the agreement of the extracted data with research-grade semi-quantitative scoring. : We included a subset of data from a multi-site NIH-funded cohort study of chronic low back pain (cLBP) participants. After initial prompt development, a secure application programming interface (API) deployment of OpenAIs GPT-4 was used to extract different classes of pathology from the clinical radiology report.

Measuring digital health literacy and its associations with determinants and health outcomes in 13 countries.

Introduction: Digital health information sources are playing an increasingly prominent role in health promotion, public health and in healthcare systems. Consequently, digital health literacy skills are likewise becoming increasingly important.

Methods: Using a concept validation approach, the aim of the study was to validate the digital health literacy measure HLS-DIGI, applied in the European Health Literacy Survey (2019-2021) of the WHO M-POHL network, analyzing data from 28,057 respondents from 13 countries.

Gender-differences in imaging phenotypes of osteoarthritis in the osteoarthritis initiative.

In osteoarthritis (OA) research it is increasingly recognized that stratification according to disease phenotypes is essential for optimizing treatment regimens. Gender-specific differences in clinical OA manifestations have been identified, and this analysis aimed to assess whether these differences extend to imaging phenotypes.From the Osteoarthritis Initiative database 2523 participants (1409 women and 1114 men) with completed 3T MRI and whole-organ magnetic resonance imaging scores (WORMS) of the right knee at baseline were included.

MRI-based analysis of thigh intramuscular fat and its associations with age, sex, and BMI using data from the osteoarthritis initiative data.

The degree of thigh intramuscular fat in individuals without OA is fundamental for distinguishing natural variations in intramuscular fat from pathological changes. The goals of this study were to estimate the degree of thigh intramuscular fat in individuals without radiographic OA or frequent pain and assess the associations of age, sex, and BMI with the degree of intramuscular fat. Individuals without knee or hip radiographic OA, without total knee/hip arthroplasty, and without frequent knee/hip pain were selected from the OAI database (n = 710).

[Measuring health literacy: methods and tools for assessing general health literacy in adults].

The measurement of health literacy (HL) began in the 1990s with instruments that focused on a functional understanding of HL. Since then, the understanding of HL and the measurement of HL have evolved. This article reviews two particularly well-validated instruments for measuring comprehensive general health literacy: The Health Literacy Questionnaire (HLQ) and the HLS-Q12 questionnaire.

Pathways of how health literacy and social support are associated with health outcomes in 17 European countries: Results of mediation analyses.

Objectives: To estimate and compare (1) how social support (SS) acts as a mediator for the association between health literacy (HL) and health outcomes, and (2) how HL acts as a mediator for the association between SS and health outcomes.

Study Design: Mediation analyses.

Methods: Data from the Health Literacy Survey 2019 (HLS) were analyzed including 42,445 participants in 17 European countries.

Quantifying knee-adjacent subcutaneous fat in the entire OAI baseline dataset - Associations with cartilage MRI T, thickness and pain, independent of BMI.

Objective: Knee-adjacent subcutaneous fat (kaSCF) has emerged as a potential biomarker and risk factor for osteoarthritis (OA) progression. This study aims to develop an artificial intelligence-based tool for the automatic segmentation of kaSCF thickness and evaluate the cross-sectional associations between kaSCF, cartilage thickness, magnetic resonance imaging-based cartilage T relaxation time, knee pain, and muscle strength independent of body mass index (BMI).

Design: Baseline 3.

The Condition of the Meniscus and Cartilage of the Injured Knee on Preoperative Magnetic Resonance Imaging Is a Prognostic Factor Affecting Postoperative Outcomes Following Knee Cartilage Restoration Surgery.

Purpose: To evaluate the relationship between preoperative whole-joint imaging evaluation of the knee with patient-reported outcome (PRO) measures after cartilage restoration surgery (mosaicplasty, osteochondral allograft transplantation, matrix autologous chondrocyte implantation).

Methods: We retrospectively evaluated patients who underwent knee articular cartilage restoration at our institution from 2014 to 2020. The patients' knee magnetic resonance imaging (MRI) was evaluated with the Whole-Organ Magnetic Resonance Imaging Score (WORMS) and semiquantitative synovial inflammation imaging biomarkers of the preoperative MRI.

Longitudinal Changes in Medial Meniscal Extrusion After ACL Injury and Reconstruction and Its Relationship With Cartilage Degeneration Assessed Using MRI-Based T1ρ and T2 Analysis.

Background: Anterior cruciate ligament (ACL) injury often leads to posttraumatic osteoarthritis (PTOA), despite ACL reconstruction (ACLR). Medial meniscal extrusion (MME) is implicated in PTOA progression but remains understudied after ACL injury and ACLR.

Hypothesis/purpose: It was hypothesized that MME would increase longitudinally after ACL injury and ACLR, with greater changes in the ipsilateral knee compared with the contralateral knee, leading to cartilage degeneration.

The impact of cerebrovascular steno-occlusive disease subtype on surgical and clinical outcomes after direct STA-MCA bypass surgery.

Objective: Although well-established in moyamoya disease (MMD), the role of direct superficial temporal artery (STA) to middle cerebral artery (MCA) bypass in non-MMD (N-MMD) cerebrovascular steno-occlusive syndromes remains controversial. Nonetheless, the recurrent stroke risk in patients with N-MMD, despite best medical management, remains exceedingly high-especially for those suffering from hypoperfusion-related ischemia. The study objective was to determine the relative safety and efficacy profiles of direct STA-MCA bypass surgery for MMD and N-MMD patients in a large contemporary cohort.

Unusual bone abnormalities from therapeutic ultrasound diathermy: a radiological case report.

This report describes bone marrow abnormalities arising as a consequence of therapeutic ultrasound diathermy, which are an uncommon diagnostic entity. Over the period from 2018 to 2023, 11 patients were identified that showed abnormalities of the bone marrow on MRI, as a direct result of ultrasound diathermy treatment. These abnormalities displayed consistent imaging features, characterized by areas of low T1W and high T2W signal intensity with well-demarcated geographic margins and central fatty areas, as can be seen in bone infarction.

Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma.

Background: Subacute and chronic subdural hematomas are common and frequently recur after surgical evacuation. The effect of adjunctive middle meningeal artery embolization on the risk of reoperation remains unclear.

Methods: In a prospective, multicenter, interventional, adaptive-design trial, we randomly assigned patients with symptomatic subacute or chronic subdural hematoma with an indication for surgical evacuation to undergo middle meningeal artery embolization plus surgery (treatment group) or surgery alone (control group).

Intrasaccular Treatment of Intracranial Aneurysms: A Comprehensive Review.

: The endovascular treatment of complex intracranial aneurysms, such as wide-neck aneurysms (WNAs), remains a challenge. More established endovascular techniques, which include balloon-assisted coiling, stent-assisted coiling, and flow diversion, all have their drawbacks. Intrasaccular flow disruptor devices have emerged as a useful tool for the neurointerventionalist.