Lymphoma Therapy Response Assessment with Low-Dose [F]FDG Total-Body PET/CT.

The improved sensitivity of total-body (TB) PET/CT offers the possibility of reducing injected activities. The aim of our study was to define a lower limit of reduced injected activities in [F]FDG TB PET/CT for interim and end-of-treatment assessment of patients with lymphoma at 2 acquisition times. Twenty-four consecutive patients with lymphoma who were undergoing interim and end-of-treatment TB PET/CT were prospectively enrolled in this study.

MRI of atypical lipomatous tumor: does contrast help? A multicenter study.

Objective: To compare the diagnostic performance of non-contrast MRI versus MRI with contrast for differentiating atypical lipomatous tumors (ALT) from lipomas.

Materials And Methods: This multicenter retrospective study included subjects with a histopathologic diagnosis of lipoma or ALT and a preoperative MRI study with contrast. An experienced musculoskeletal radiologist reviewed the images in two sessions, the first session with non-contrast only, and the second session, including postcontrast sequences.

Diagnostic accuracy in NSCLC lymph node staging with Total-Body and conventional PET/CT.

Introduction: Our aim was to characterize the diagnostic accuracy indices for nodal (N)-staging with [F]FDG Total-Body (TB) and short-axial field-of-view (SAFOV) PET/CT in non-small cell lung cancer (NSCLC) patients referred for staging or restaging.

Methods: In this prospective single center cross-over head-to-head comparative study 48 patients underwent [F]FDG TB and SAFOV PET/CT on the same day. In total 700 lymph node levels (1R/L, 2R/L, 3a/p, 4R/L, 5, 6, 7, 8R/L, 9R/L, 10-14R/L) of 28 patients could be correlated to a composite reference standard (histopathological correlation, imaging after localized or systemic treatment), which allowed determination of true positive (TP), false positive (FP), true negative (TN) and false negative (FN) lesions.

Glove Phenomenon Detected by Total-Body PET/CT With 68 GA-DOTATATE.

Accidental intra-arterial injections of radiotracers are rare events resulting in a specific imaging pattern, described as "hot-forearm," "hot-hand," "glove-phenomenon," or "glove-like pattern." We present a case 68 Ga-DOTATATE total-body PET/CT for restaging of a neuroendocrine tumor, where intra-arterial misinjection resulted in a glove phenomenon. Since patients may present with minimal symptoms, like in this case, and PET findings may only be seen at the distal upper extremity (placed above the head), these accidental injections may be more frequently detected with total-body PET/CT due to the longer field-of-view.

Refining penalty parameter selection in whole-body PET image reconstruction for lung cancer patients using the cross-validation log-likelihood method.

Penalty parameters in penalized likelihood positron emission tomography (PET) reconstruction are typically determined empirically. The cross-validation log-likelihood (CVLL) method has been introduced to optimize these parameters by maximizing a CVLL function, which assesses the likelihood of reconstructed images using one subset of a list-mode dataset based on another subset. This study aims to validate the efficacy of the CVLL method in whole-body imaging for cancer patients using a conventional clinical PET scanner.

Long-Axial Field-of-View PET Imaging in Patients with Lymphoma: Challenges and Opportunities.

[F]fluoro-2-deoxy-d-glucose PET/computed tomography has been implemented in the management of patients with lymphoma, offering real-time metabolic information on lymphoma with the promise of more accurate staging, treatment response assessment, prognostication, and early detection of disease recurrence. The clinical management of lymphoproliferative disease has recently, rapidly evolved from initial chemotherapeutic to the use of immunotherapy, targeted agents, and to the use of chimeric antigen receptor T-cell therapies. The implementation of these new systems and imaging protocols together with new tracer development creates, in the field of lymphoproliferative disease, both opportunities and challenges that will be detailed in this comprehensive literature review.

Dose Reduction in Pediatric Oncology Patients with Delayed Total-Body [F]FDG PET/CT.

Our aim was to define a lower limit of reduced injected activity in delayed [F]FDG total-body (TB) PET/CT in pediatric oncology patients. In this single-center prospective study, children were scanned for 20 min with TB PET/CT, 120 min after intravenous administration of a 4.07 ± 0.

The role of real-time elastosonography in the diagnosis of quadriceps fat pad edema.

Background: Quadriceps fat pad edema (QFPE) is one of the causes of anterior knee pain. Real-time elastosonography (RTE) has been increasingly used in musculoskeletal disorders.

Purpose: To evaluate the role of RTE in the diagnosis of QFPE.