Publications by authors named "Thanh H Nguyen"

With the recent popularity of neural networks comes the need for efficient serving of inference workloads. A neural network inference workload can be represented as a computational graph with nodes as operators transforming multidimensional tensors. The tensors can be transposed and/or tiled in a combinatorially large number of ways, some configurations leading to accelerated inference.

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Background: Despite the successful implementation of the Expanded Programme on Immunization (EPI) for the past three decades, Vietnam has recently witnessed outbreaks of vaccine-preventable diseases, indicating a potential gap in immunisation uptake across population groups. Daklak province is a rural highland area, home to 46 ethnic groups with complicated socio-economic backgrounds. The province reported sporadic outbreaks of vaccine-preventable diseases and low vaccine uptake in some remote low-socioeconomic groups despite a high record of provincial coverage.

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The objective of this scoping review is to explore the systemic barriers that impact health inequities among vulnerable populations (e.g., racial/ethnic and gender groups, people with disabilities, refugees, immigrants, elders, young children, agricultural and fishery workers, and low-income individuals) when facing climate change stressors.

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Microplastics (MPs) are widespread in marine sediments, and they have become an emerging global pollutant due to their potential threats to marine ecosystems. However, there is limited research on the distribution of MPs and meiofauna in estuarine sediments. MPs and meiofauna abundances were identified in sediments of 12 stations along the Van Uc estuary in rainy and dry seasons.

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In the fusion-positive subset of rhabdomyosarcoma, the PAX3::FOXO1 oncoprotein is the most common fusion driver. We previously established a human myoblast system for inducible expression of PAX3::FOXO1. In the current study, we modulate PAX3::FOXO1 protein expression to understand the epigenetic and phenotypic functions at different PAX3::FOXO1 levels.

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Objective: The prognostic factors of patients diagnosed with marginal zone B-cell lymphoma at the National Institute of Hematology and Blood Transfusion between January 2014 and January 2024 were analyzed.

Subjects And Methods: This cross-sectional descriptive study included 86 newly diagnosed and treated marginal zone B-cell lymphoma patients. Myelogram, histopathology, and immunohistochemical staining were performed for all patients.

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Electrochemical green hydrogen production via water splitting is an attractive and sustainable pathway; however, the sluggish kinetics of anodic oxygen evolution reaction is still a critical challenge. In this study, an effective electrocatalyst engineering approach is demonstrated by preparing an innovative hybrid of ruthenium d-orbitals-regulated nanoclusters embedding within functionalized hollow TiC MXene networks (RuNi-N/O-TiC) to promote the hydrazine-assisted hydrogen production. A specific charge redistribution is revealed, locally concentrating at interfaces derived from stable Ru(Ni)-N/O-Ti coordination and d-p orbital hybridization.

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Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a life-threatening condition characterized by transient left ventricular dysfunction with nonischemic abnormalities. This syndrome in scenarios of anaphylactic shock is quite rare, with only a few cases reported. Early diagnosis and treatment are crucial.

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Unlabelled: Relative humidity (RH) varies widely in indoor environments based on temperature, outdoor humidity, heating systems, and other environmental conditions. This study explored how RH affects aerosolized porcine respiratory coronavirus (PRCV), a model for coronaviruses, over a time range from 0 min to a maximum of 1 h, and the molecular mechanism behind viral infectivity reduction. These questions were answered by quantifying: (i) viral-host receptor interactions, (ii) capsid integrity, (iii) viral genome integrity, and (iv) virus infectivity.

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Purpose: Vietnam is estimated to have approximately 30,000 hemophilia B (HB) carriers, with hundreds of new cases registered annually. However, comprehensive molecular studies on HB remain limited. Therefore, this study aimed to characterize genetic variants and assess their clinical significance in unrelated Vietnamese patients with HB.

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The GdO:Eu nanoparticles were synthesized using a multi-step chemical method with urea as a reactant to control the ratio of different Eu activation centers: 2, 4, 6, 8, 10, and 12 mol% combined with CTAB surfactant to improve surface quality. The study aimed to determine the optimal concentration of Eu in the presence of CTAB to increase biocompatibility and achieve the best fluorescence. The structure, surface morphology, optical properties, and magnetic properties of the materials were analyzed through FSEM, XRD, HRTEM, XPS, UV-vis, fluorescence, fluorescence excitation, time-resolved fluorescence, vibrating sample magnetometry (VSM), and magnetic heating measurements.

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Background: Bayesian area under the curve (AUC)-guided vancomycin dosing, preferably with 2 samples (2S), is recommended for pediatric patients. However, the timing of sampling may not always be convenient in the clinical setting. In low- to middle-income countries, the implementation of model-informed precision dosing (MIPD) using the Bayesian approach remains limited because of high software costs.

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Background And Objectives: Blood safety is the top priority in transfusion medicine. However, patients in Vietnam are only transfused with ABO and RhD compatible blood products, which could pose a threat to induce alloimmunization. This study was performed to provide information about the frequencies of antigens and phenotypes of clinically significant blood groups in Vietnamese donors.

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This work systematically investigated the relationship between the microstructure, and mechanical and magnetic properties of FeCoNiAlNb high-entropy alloy. Our results indicated that the microstructure of the alloy comprised a BCC solid solution phase along with a eutectic mixture of FCC and intermetallic phases. The application of heat treatment resulted in a significant evolution of the microstructure.

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The conversion of electricity into hydrogen (H) gas through electrochemical water splitting using efficient electrocatalysts has been one of the most important future technologies to create vast amounts of clean and renewable energy. Low-temperature electrolyzer systems, such as proton exchange membrane water electrolyzers, alkaline water electrolyzers, and anion exchange membrane water electrolyzers are at the forefront of current technologies. Their performance, however, generally depends on electricity costs and system efficiency, which can be significantly improved by developing high-performance electrocatalysts to enhance the kinetics of both the cathodic hydrogen evolution reaction and the anodic oxygen evolution reaction.

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The spread of antibiotic resistance genes (ARGs) in the environment is a global public health concern. To date, over 5000 genes have been identified to express resistance to antibiotics. ARGs are usually low in abundance for wastewater samples, making them difficult to detect.

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This work examined the attachment of porcine rotavirus (PRV) and Tulane virus (TV), a surrogate for human norovirus, to fresh and artificial phylloplanes of Romaine lettuce and Carmel spinach. The effect of produce type, sanitizer, and ultrasound treatment on removal of PRV and TV from produce and artificial surfaces was also investigated. Sanitization was performed with two oxidant-based sanitizers (chlorine and peroxyacetic acid) and one surfactant-based sanitizer (0.

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Data sharing holds promise to accelerate innovative discoveries through artificial intelligence (AI) and traditional analytics. However, it remains unclear whether these prospects translate into tangible benefits in improving health care and scientific progress. In this cross-sectional study, we investigate current data reuse practices and explore ways to enhance the use of existing data in clinical research, focusing on low- and middle-income countries.

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Article Synopsis
  • The study investigates the significance of cardiac troponin (cTn) levels in predicting mortality in patients with Takotsubo syndrome (TTS), analyzing data from the International Takotsubo Registry.
  • It identifies that a cTn increase greater than 28.8 times the upper reference limit signals clinically relevant myocardial injury, correlating with a higher risk of mortality over 5 years (adjusted HR 1.58).
  • The findings enhance understanding of patient risk profiles in TTS, emphasizing the need for increased monitoring and follow-up for those with significant troponin elevations.
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Enhancement of an alkaline water splitting reaction in Pt-based single-atom catalysts (SACs) relies on effective metal-support interactions. A Pt single atom (Pt)-immobilized three-phased Pt@VP-NiP-MoP heterostructure on nickel foam is presented, demonstrating high catalytic performance. The existence of Pt on triphasic metal phosphides gives an outstanding performance toward overall water splitting.

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  • Current influenza vaccines have limited effectiveness (19%-60%) and existing treatments are ineffective in advanced stages, leading to significant death rates in the U.S. (25,000-72,000/year) and concerns with avian strains infecting humans.
  • Researchers developed zanDR, a bispecific small molecule that inhibits the virus's neuraminidase and recruits anti-rhamnose and anti-DNP antibodies, effectively mimicking the functions of both antiviral treatments and vaccines.
  • Studies show that zanDR provides 100% protection in severely infected mice with a single dose, reducing viral loads much more effectively than current therapies, while also lowering inflammation and protecting lung tissue, suggesting a promising combined immunotherapy and chemotherapy approach.
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Timely surveillance of airborne pathogens is essential to preventing the spread of infectious diseases and safeguard human health. Methods for sensitive, efficient, and cost-effective detection of airborne viruses are needed. With advances in synthetic biology, whole-cell biosensors have emerged as promising platforms for environmental monitoring and medical diagnostics.

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Article Synopsis
  • Skeletal dysplasias are a group of rare genetic disorders that disrupt the normal development of bones and cartilage, with over 770 documented cases.
  • A 13-month-old girl presented with jaundice and failure to thrive, leading to blood tests that showed abnormal levels of bilirubin and calcium, alongside irregular bone development.
  • Whole exome sequencing identified a specific mutation in the BAAT gene as the cause of her skeletal dysplasia, contributing important genetic insights for future clinical applications.
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Article Synopsis
  • The study investigated changes in demographics, risk factors, clinical presentations, and outcomes of takotsubo syndrome (TTS) patients from 2004 to 2021, using data from the InterTAK registry.
  • Over the years, the proportion of male patients increased, and there was a rise in cases of midventricular TTS as well as significant growth in the incidence of physical triggers.
  • There was also a notable increase in 60-day mortality rates, although no significant change in 1-year mortality when excluding early deaths was observed, indicating a complex evolution of TTS and its management in recent years.
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