Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides.

This study aims to synthesize semicarbazides and thiosemicarbazides and evaluate them for their biological potential. In the current study, the hydrazide was used as a precursor for the synthesis of semicarbazides (-) and thiosemicarbazides (-). The synthesized compounds were evaluated for their anticancer activity against neuroblastoma cells (IMR-32), malignant glioma cells (U87), and fibroblasts (NIH3T3) and antioxidant potential.

Assessment of heavy metals and microbial loads in Nile tilapia (Oreochromis niloticus) from different farms and rivers.

Metal contamination in water bodies globally poses risks to ecosystems and human health. In Pakistan, water sources are impacted by toxic metals and microbial pollutants, affecting Nile Tilapia, a widely consumed fish in Punjab. This study assessed heavy metal and microbiological contamination in Nile tilapia from the Ravi and Chenab Rivers and nearby farms (Head Muhammad Wala, Shorkot, and Rangpur).

Nutritional and antioxidative characterization, antimicrobial and sensorial stability of flaxseed powder supplemented mutton patties.

Oxidative stress and microbial growth deteriorate food quality and cause safety risks. Therefore, the present study was investigated to explore the nutritional, sensorial, anti-oxidative and anti-microbial attributes of flaxseed powder (FP) supplemented at 2-8 % (i.e.

Effect of thermal and non-thermal processing on Technofunctional, nutritional, safety and sensorial attributes of potato powder.

Potato is a highly nutritious staple food however, it also contains some antinutrients like alkaloids, phytates, tannins, oxalates as well as pesticide residues. Therefore, this study was conducted to reduce the loads of antinutrients and pesticides in potato powder (PP) using thermal and non-thermal processing techniques. Nutritional analysis revealed that the raw PP contained significantly ( < 0.

Enhancing iron and zinc bioavailability in maize () through phytate reduction: the impact of fermentation alone and in combination with soaking and germination.

Introduction: Phytates are nutrient-binding compounds found mainly in cereals and legumes, which may significantly contribute to micronutrient malnutrition in regions where phytate-rich cereals, such as maize, are staple food.

Objectives: This study investigated how maize fermentation, both alone and in combination with soaking and germination, can reduce phytate levels and enhance the estimated bioavailability of iron and zinc.

Methods: We evaluated various fermentation methods, including spontaneous fermentation; fermentation with starter cultures, either 299v (Lp299) or yogurt containing viable ; and fermentation with Lp299 of soaked and germinated maize.

Bioactivity Profiling and Phytochemical Analysis of Extracts: Antioxidant, Anti-Inflammatory, and Anti-Urinary Tract Infection Properties.

L. (Apocynaceae) is widely distributed in tropical and subtropical regions of Asia including Pakistan, India, Afghanistan, and Sri Lanka. is considered as an integral component of traditional medicinal systems to combat several health ailments.

Retraction of "Toxicological Screening of 4-Phenyl-3,4-dihydrobenzo[]quinolin-2(1)-one: A New Potential Candidate for Alzheimer's Treatment".

[This retracts the article DOI: 10.1021/acsomega.1c00654.

Effect of Short-Term Lactic Fermentation on Polyphenol Profile and Antioxidant Capacity in White and Red Quinoa Varieties.

Quinoa ( Willd.) is a pseudocereal originally grown in the Andean region of South America. This study focused on investigating the changes in phenolic profile and antioxidant capacity in white and red quinoa varieties after short-term fermentation with 299v.

Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol.

Background: Zinc deficiency poses significant health risks, particularly in low-income settings. This study aims to evaluate the impact of agronomically zinc biofortified (fermented and non-fermented) and post-harvest wheat flour flatbread on zinc status and metabolic health in adolescents and adult women in rural Pakistan.

Methods: A four-arm triple-blind randomized controlled trial will be conducted in a rural district of Pakistan.

Correction: Abbas et al. Bioactive Compounds, Antioxidant, Anti-Inflammatory, Anti-Cancer, and Toxicity Assessment of -In Vitro and In Vivo Studies. 2022, , 1160.

In the original publication [...

Biochar-based organic fertilizers: Influence on yield and concentration of antioxidants in the stigma of saffron and rhizosphere bacterial diversity of slightly saline and non-saline soils.

Being the most expensive spice, saffron has great economic importance. This crop grows well in cold arid deserts. Salinity is one of the important limiting factors for the cultivation of this crop.

Effect of Growth Stages and Lactic Acid Fermentation on Anti-Nutrients and Nutritional Attributes of Spinach ().

Spinach () is a winter-season green, leafy vegetable grown all over the world, belonging to the family , sub-family . Spinach is a low-caloric food and an enormous source of micronutrients, e.g.

The Comparative Effect of Lactic Acid Fermentation and Germination on the Levels of Neurotoxin, Anti-Nutrients, and Nutritional Attributes of Sweet Blue Pea ( L.).

Grass pea ( L.), an indigenous legume of the subcontinental region, is a promising source of protein and other nutrients of health significance. Contrarily, a high amount of β-N-oxalyl-l-α,β-diaminopropionic acid (β-ODAP) and other anti-nutrients limits its wider acceptability as healthier substitute to protein of animal and plant origin.

Administration of α-lipoic acid and silymarin attenuates aggression by modulating endocrine, oxidative stress and inflammatory pathways in mice.

Aggression, a highly prevalent behavior among all the psychological disorders having strong association with psychiatric imbalance, neuroendocrine changes and neurological disturbances (including oxidative stress & neuroinflammation) require both pharmacological and non-pharmacological treatments. Focusing the preclinical neuroendocrine determinants of aggression, this interventional study was designed to elucidate the curative effect of antioxidants on aggression in male mice. Adult albino male mice (n = 140) randomly divided into two main treatment groups for α-lipoic acid (ALA) and silymarin with 5 subgroups (n = 10) for each curative study, namely control, disease (aggression-induced), standard (diazepam, 2.

Toxicity profiling of Burgmansia aurea Lagerh. Leaves using acute and sub-acute toxicity studies in rats.

Ethnopharmacological Relevance: Toxicity studies in appropriate animal models are an integral and very important component of pre-clinical studies in drug development. Brugmansia aurea lagerh. is used for both medicinal and non-medical purposes, including treating skin infections, different types of physical discomfort, inflammation, cough, hallucinations, and evil protection.

The wound healing potential of Hedychium spicatum Sm. and Zinnia peruviana (L.) ethanolic extracts against excision wound model in rats.

Ethnopharmacological Relevance: Medicinal plants used for wound healing, are key to unlock the doors for combating the resistance of pathogens by provision of new source of compounds.

Aim Of The Study: This study is aimed to evaluate and compare the wound healing properties of ethanolic extract of Hedychium spicatum Sm. rhizome and of Zinnia peruviana's leaves and roots.

Combined antidiabetic potential of camel milk yogurt with and by using rodent modelling.

This study aimed to evaluate anti-diabetic potential of functional camel milk yogurt enriched with and that not only mask its peculiar flavour rather have an antidiabetic effect as well. Sixty-three pathogen free STZ-induced albino Wistar rats were categorized into 7 groups on the basis of treatments. From each treatment group three animals were dissected periodically at 0, 7 and 21 days of study to determine the effect of all treatments on physicochemical parameters, serum glucose, serum chemistry and haematology.

Inhibition of Oxidative Stress and the NF-κB Pathway by a Vitamin E Derivative: Pharmacological Approach against Parkinson's Disease.

Parkinson's disease (PD) is a progressive neurodegenerative disorder. In this study, PD was induced via (ip) injection of haloperidol (1 mg/kg/day). Animals were divided into seven groups ( = 70).

Effect of Thermal and Non-Thermal Processing on Nutritional, Functional, Safety Characteristics and Sensory Quality of White Cabbage Powder.

This study was aimed to improve nutritional, functional and consumer safety aspects of cabbage powder (CP). White cabbage (Brassica oleracea var. capitata f.

Antidiabetic effects of leaf extract by modulating the glucose levels, insulin resistance, and oxidative stress mechanism.

Background: , a genus of the Solanaceae family, has historically been utilized in many different parts of the world as an anti-inflammatory for treating skin infections, wounds, and bodily aches and pains. The current study aimed to investigate the potential benefits of a methanolic extract of in the management of diabetes and underlying complications in alloxanized-induced diabetic rats.

Materials And Methods: Animals were divided into nine groups ( = 6).

Antioxidant Effect of Essential Oil and Its Effect on Cooking Qualities of Supplemented Chicken Nuggets.

A commonly observed chicken meat issue is its lipid oxidation that leads to deterioration of its organoleptic and nutritional properties and its further-processed products. Basil L.) is one of the traditional culinary herbs exhibiting food preservation properties.

Establishing Height-for-Age Z-Score Growth Reference Curves and Stunting Prevalence in Children and Adolescents in Pakistan.

Height-for-age Z-score (HAZ) curves are widely used for detecting children with stunting. The aim of this study was to provide smoothed HAZ growth reference values and their curves for Pakistani children and adolescents aged 2-18 years. The prevalence of stunting in Pakistani children was determined.