Reverse Effects of Nicotinamide Mononucleotide Supplementation on Declining Quality of Oocytes With Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) adversely impacts oocyte quality, underscoring effective interventions as a central focus of research. Our study demonstrates that nicotinamide mononucleotide (NMN) not only restores NAD homeostasis in oocytes from PCOS mice but also enhances the developmental rate of PCOS oocytes during in vitro maturation (IVM). Transcriptomic analysis and experimental validation suggest that NMN helps reverse the decline in PCOS oocyte quality by mitigating oxidative stress, improving mitochondrial function, and preserving spindle morphology.

Adverse impact of paternal age on embryo euploidy: insights from retrospective analysis and interpretable Machine learning.

The trend of delayed childbearing has increased the average age of parents, with the impact of paternal age on embryo euploidy remaining controversial. Therefore, this study aimed to investigate the impact of paternal age on embryo euploidy using retrospective clinical data and interpretable machine learning. This retrospective study included 960 couples and 4,718 embryos undergoing preimplantation genetic testing for aneuploidy (PGT-A).

Comparison of pregnancy outcomes for high morphological scoring mosaic vs. low morphological scoring euploid embryos: a retrospective cohort study.

Background: Mosaic embryos have been proven to be capable of resulting in live births and have become an option for embryo transfer under certain circumstances. Recent guidelines suggested that embryo morphological scoring should be taken into consideration when selecting mosaic embryos for transfer. Therefore, we introduce a hypothesis that a high morphological scoring mosaic embryo is a better choice compared to a low morphological scoring euploid embryo.

Diminished ovarian reserve may have no effect on embryo euploidy: A retrospective cohort study.

Objective: Does an association exist between diminished ovarian reserve (DOR) and embryonic aneuploidy risk in young women of reproductive age?

Methods: This retrospective cohort study included 854 participants treated in the Department of Reproductive Medicine, Women's Hospital of Nanjing Medicine University, Nanjing Maternity and Child Health Care Hospital, from May 2016 to September 2023 for a total of 894 cycles. The relationship between ovarian reserve and embryonic euploidy was evaluated using statistical methods such as generalized estimating equation (GEE) and propensity score matching (PSM).

Results: Despite the higher number of biopsied blastocysts in women with normal ovarian reserve, no significant difference in embryonic aneuploidy rates was observed between DOR women and the control group.