Anthropometric Indices for Predicting Incident Cardiovascular Disease : A 13-Year Follow-Up Study in a Japanese population.

Background: No previous study has compared the predictive capacity of various anthropometric indices of cardiovascular disease (CVD) risk in East Asians.

Objective: This study aimed to compare which anthropometric indices have greater impact on CVD in the Japanese population.

Methods: Data from a health checkup program conducted by the Panasonic Corporation between 2008 and 2021, including 160,656 participants, were analyzed.

Association of sex hormone-binding globulin and dyslipidemia with Japanese postmenopausal women: a cross-sectional study.

Background: In postmenopausal women, lower levels of sex hormone-binding globulin (SHBG) have been linked to various metabolic conditions. The association between SHBG levels and the presence of dyslipidemia was investigated in comparison with other sex hormones.

Methods: Data from 570 postmenopausal women were analyzed.

Prognostic impact of ER-staining patterns and heterogeneity of ER positive HER2 negative breast cancer.

Background: Estrogen receptor (ER) expression is critical in breast cancer treatment. While low ER (1-9%) resembles triple-negative cancer with chemotherapy efficacy, the significance of "intermediate expression" (≥ 10%) and the therapeutic efficacy remain unclear. This study explores the differences in staining patterns and molecular characteristics of ER-low to intermediate expression to guide treatment.

ATPase copper transporting beta attenuates malignant features with high expression as an indicator of favorable prognosis in breast cancer.

Background: ATPase copper transporting beta (ATP7B) functions as a copper-transporting ATPase that ejects copper from cells. Although high expression of ATP7B has been reported to increase cisplatin resistance, its role in breast cancer (BC) remains unclear. This study aimed to elucidate the function of ATP7B in BC cells and its significance in patients with BC.

Relationship between anthropometric measures and the risk of incident Metabolic dysfunction-associated steatotic liver disease: a longitudinal study.

Background: Waist circumference (WC) and body mass index (BMI) are considered useful for the diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to investigate the association between the body roundness index (BRI) and a body shape index (ABSI) with incident MASLD, in comparison to WC and BMI.

Methods: Retrospective cohort data from a Japanese health check-up program were analyzed.

Estimated Glucose Disposal Rate Predicts the Risk of Incident Metabolic Dysfunction-Associated Steatotic Liver Disease.

Objectives: There is a relationship between insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD) and the estimated glucose disposal rate (eGDR), which has been reported as a surrogate marker of insulin resistance. This study aimed to investigate the association between eGDR and the incident MASLD, and compare the ability to predict incident MASLD with other insulin resistance markers.

Methods: Retrospective cohort data from a health check-up program were analyzed.

Adenylate cyclase 9 expression level is associated with hormone receptor-positive breast cancer and predicts patient prognosis.

Adenylate cyclase family members have recently received attention as novel therapeutic targets. However, the significance of adenylate cyclase 9 (ADCY9) in breast cancer has not been elucidated. Here, we evaluated expression in breast cancer (BC) cell lines, and polymerase chain reaction array analysis was performed to determine the correlations between expression levels and 84 tumor-associated genes.

Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study.

Background: This study aimed to explore the relationship between ultra-processed foods (UPFs) consumption and gut microbiota in patients with type 2 diabetes (T2D).

Methods: This cross-sectional study included 362 participants with T2D. UPFs consumption was assessed using a brief-type self-administered diet history questionnaire, quantified as the density of UPFs intake (g/1000 kcal).

Design of Functional Gyroid Minimal Surfaces Transporting Proton Based Solely on Surface Hopping Conduction Mechanism.

Surface proton hopping conduction (SPHC) mechanisms is an important proton conduction mechanism in conventional polymer electrolytes, along with the Grotthuss and vehicle mechanisms. Due to the small diffusion coefficient of protons in the SPHC mechanism, few studies have focused on the SPHC mechanism. Recently, it has been found that a dense alignment of SO groups significantly lowers the activation energy in the SPHC mechanism, enabling fast proton conduction.

Mechanistic model of minute virus of mice elution behavior in anion exchange chromatography purification.

This study aimed to propose a methodology for developing a mechanistic model for viral clearance of the minute virus of mice (MVM) on flow-through anion exchange (AEX) chromatography. Protein surface analysis was applied to investigate the possibility of molecular interaction between the recombinant biotherapeutic and MVM. The protein product-free Tris buffers were spiked with MVM, and the MVM elution profile from AEX chromatography was quantitatively analyzed using quantitative polymerase chain reaction (qPCR) for pooled fractions.

Impact of periodic neck ultrasonography on locoregional disease control in surveillance after total thyroidectomy for patients with low- and intermediate-risk papillary thyroid carcinoma: a propensity score-matched study.

This study aimed to evaluate the impact of periodic neck ultrasonography (US) on postoperative surveillance for locoregional disease control of patients with low- and intermediate-risk papillary thyroid carcinoma (PTC) who underwent total thyroidectomy. This retrospective cohort study included patients with PTC who underwent total thyroidectomy and central neck dissection at our institution between January, 2000 and December, 2016. The patients were divided into two groups: the physical examination (PE) group (follow-up by PE without periodic US) and the US group (follow-up by PE with periodic US).

Design of V-shaped ionic liquid crystals: atropisomerisation ability and formation of double-gyroid molecular assemblies.

We designed V-shaped ionic liquid crystals with two sterically congested ionic parts at the vertex. Depending on the degree of steric hindrance, atropisomerisation occurred in solution. All compounds formed bicontinuous cubic phases with double-gyroid structures in the bulk state, partially owing to the co-existence of atropisomers with opposite chirality.

Efficacy of long-term low carbohydrate diets for patients with type 2 diabetes: A systematic review and meta-analysis.

Aims/introduction: Efficacy of long-term low-carbohydrate diets (LCD) to improve glycemic management for type 2 diabetes remains controversial. Thus, we investigated the association between long-term LCD and glycemic control in individuals with type 2 diabetes.

Materials And Methods: We searched PubMed, Embase and the Cochrane Database for articles published up to June 2023, and included randomized controlled trials conducted on LCD interventions for >12 months in adults with type 2 diabetes.

Surface proton hopping conduction mechanism dominant polymer electrolytes created by self-assembly of bicontinuous cubic liquid crystals.

For the development of the next generation of fuel cells, it is essential to create an innovative design principle of polymer electrolytes that is beyond extension of the existing strategy. In the present study, we focused on the surface hopping proton conduction mechanism where an activation energy for proton conduction is greatly reduced by decreasing the distance between SO groups. Our gyroid nanostructured polymer film (Film-G), with a hydrophilic surface where the SO groups are aligned densely and precisely, shows high proton conductivity of the order of 10 S cm when the water content is about 15 wt%.

The transition of metabolic phenotypes and cardiovascular events: Panasonic cohort study 16.

Objective: The study objective was to investigate whether changes in metabolic phenotype affect the risk of cardiovascular events.

Methods: All 117,589 participants were included in this retrospective cohort study. The metabolic phenotypes of the participants were assessed at two points (the second evaluation was set 2 years after the first evaluation), and the incidence rate of cardiovascular events was observed for 11 years.

Association of Elevated Serum Branched-chain Amino Acid Levels With Longitudinal Skeletal Muscle Loss.

Context: Branched-chain amino acids (BCAA) are substrates for protein synthesis. Although their intake may contribute to an increase in skeletal muscle mass, elevated serum BCAA levels have been reported to be associated with insulin resistance, potentially resulting in decreased skeletal muscle mass.

Objective: This study aimed to explore the association between elevated serum BCAA levels and longitudinal skeletal muscle loss.

The Impact of Nutritional Markers and Dietary Habits on the Bioimpedance Phase Angle in Older Individuals.

Low phase angle (PhA), as determined via bioelectrical impedance analysis, reflects unhealthy aging and mortality. In this study, we assessed whether nutritional status, including serum nutritional markers and dietary habits, is related to PhA in older individuals. We recruited 212 participants (aged ≥ 65 years) who underwent medical health checkups.

Estimated small dense low-density lipoprotein-cholesterol and incident type 2 diabetes in Japanese people: Population-based Panasonic cohort study 13.

Aims: This study aimed to investigate the association between estimated small dense low-density lipoprotein (sd-LDL) and incident type 2 diabetes.

Methods: We analyzed the data from a health checkup under a program conducted by Panasonic Corporation between 2008 and 2018. A total of 120,613 participants were included, of whom 6,080 developed type 2 diabetes.