The Natural Compound CalebinA Suppresses Gemcitabine Resistance and Tumor Progression by Inhibiting Angiogenesis and Invasion Through NF-κB Signaling in Pancreatic Cancer.

Previously, we established gemcitabine (Gem)-resistant pancreatic cancer (PaCa) cell lines and showed that the acquisition of Gem resistance is accompanied by enhanced activation of the inflammatory transcription factor nuclear factor-κB (NF-κB). In this study, we focus on CalebinA, a natural compound derived from the rhizomes of turmeric, known for its potent anti-inflammatory properties. It has been suggested that this compound may exert anticancer effects by downregulating the NF-κB signaling cascade.

Assessment of Residual or Resected Disappearing Liver Metastases After Chemotherapy: The AROD Study.

Objective: To prospectively assess the incidence of residual disease in disappearing liver metastases (DLM) and evaluate associated oncologic outcomes.

Summary Background Data: DLM are colorectal liver metastases that become undetectable on imaging after chemotherapy. Although DLM are increasingly observed with modern systemic therapy and imaging, their clinical significance and appropriate management remain unclear.

Novel methods for robotic pancreaticojejunostomy: stapler closure of branched pancreatic duct and local staples removal to prevent postoperative pancreatic fistula during robotic pancreaticoduodenectomy.

Background: Postoperative pancreatic fistula (POPF) is considered to be a cause of morbidity and mortality following pancreaticoduodenectomy (PD). Currently, no reconstructive technique perfectly prevents POPF. Robotic surgery has many advantages and may enhance reconstructive surgery.

Impact of Preoperative Diabetes on Insulin Management and Nutritional Status After Total or Completion Pancreatectomy.

Background: Insulin requirements after total or completion pancreatectomy (TP/CP) remain uncertain, complicating postoperative diabetes and nutritional care. This study uncovers key factors influencing these requirements.

Methods: This retrospective study included 53 patients who underwent TP/CP between July 2005 and October 2023.

Discovery of the Clinical Candidate : A Second-Generation of SARS-CoV-2 3CL Protease Inhibitor for Treating COVID-19.

The coronavirus disease 2019 (COVID-19) pandemic crisis has been mitigated by worldwide efforts to develop vaccines and therapeutic drugs. However, there remains concern regarding public health and an unmet need for therapeutic options. Herein, we report the discovery of , a second-generation SARS-CoV-2 3C-like protease (3CL) inhibitor, to treat COVID-19.

Efficacy of preoperative endoscopic nasobiliary drainage tube placement for liver cancer adjacent to the hepatic hilum.

Purpose: Surgical resection of liver cancer adjacent to the hepatic hilum is challenging, especially in balancing remnant liver volume preservation with bile duct safety. This study evaluated the efficacy of preoperative endoscopic nasobiliary drainage (ENBD) tube placement as an intraoperative guide for bile duct preservation during liver resection.

Methods: Sixteen patients with liver cancer adjacent to the hepatic hilum who underwent preoperative ENBD tube placement and curative liver resection from 2016 to 2023 were retrospectively reviewed.

Impact of hepatospleno volume ratio on postoperative chronic liver failure after major hepatectomy for perihilar cholangiocarcinoma.

Aims: The incidence of postoperative chronic liver failure (PCLF) after major hepatectomy for perihilar cholangiocarcinoma is relatively low, but it warrants careful attention. This study aimed to analyze the risk factors for PCLF, with a specific focus on the correlation with postoperative changes in liver and spleen volumes.

Methods: A total of 172 patients who underwent major hepatectomy for perihilar cholangiocarcinoma between 2006 and 2021 were included in the study.

Arterial resection and divestment in pancreatic cancer surgery in the era of multidisciplinary treatment: decadal comparative study.

Background: The aim of this study was to investigate the feasibility and effectiveness of pancreatectomy with arterial resection/divestment for pancreatic cancer with arterial involvement in the modern era of multidisciplinary treatment.

Methods: Patients who underwent pancreatectomy with arterial resection/pancreatectomy with arterial divestment for pancreatic cancer with arterial involvement from 2010 to 2021 were retrospectively analysed, and outcomes were compared between the former (2010-2015) and latter interval (2016-2021). Survivals were compared by univariable and multivariable analyses.

Polyglycolic Acid Mesh and Fibrin Glue in Minimally Invasive Left Pancreatectomy: Video Technique and Single-Center Data.

Background: Postoperative pancreatic fistula (POPF) remains a major challenge after left pancreatectomy (LP). While polyglycolic acid (PGA) mesh wrapping has been shown to reduce clinically relevant (CR-)POPF in open LP, its efficacy in minimally invasive LP (MILP) remains unvalidated. This study evaluates the effectiveness of PGA mesh and fibrin glue reinforcement during MILP in a single-center retrospective cohort.

Technique of Circumferential Divestment of the Superior Mesenteric Artery for Locally Advanced Pancreatic Cancer.

Background: Locally advanced pancreatic cancer (LAPC) that involves more than 180° of contact with the superior mesenteric artery (SMA) is defined as unresectable. With advances in multimodal therapies, some cases with a favorable response to induction treatment have become candidates for resection. Although divestment of the SMA is now widely adopted, a standardized surgical technique for resecting tumors that encircle the SMA has yet to be established.

Giant Rashba splitting in PtTe/PtTe heterostructure.

Achieving a large spin splitting is highly desirable for spintronic devices, which often requires breaking of the inversion symmetry. However, many atomically thin films are centrosymmetric, making them unsuitable for spintronic applications. Here, we report a strategy to achieve inversion symmetry breaking from a centrosymmetric transition metal dichalcogenide (TMDC) bilayer PtTe, leading to a giant Rashba spin splitting.

A Multimodal Approach Utilizing Balloon Occlusion for Postpancreatectomy Hemorrhage: A Case Report.

Introduction: Postpancreatectomy hemorrhage (PPH) is a life-threatening complication following pancreaticoduodenectomy, requiring prompt and accurate diagnostic and therapeutic measures to ensure patient survival.

Case Presentation: A 79-year-old man underwent robot-assisted pancreaticoduodenectomy for suspected intraductal papillary mucinous carcinoma. Postoperatively, he developed a pancreatic fistula and major bile leak, leading to a hemorrhagic event on postoperative day 6.

A left-posterior approach to the superior mesenteric artery during robot-assisted pancreaticoduodenectomy.

Background: A complete dissection around the superior mesenteric artery (SMA) with artery-first concept is crucial during pancreaticoduodenectomy for periampullary cancers. The left-posterior (LP) approach to the SMA may be effective during robot-assisted pancreaticoduodenectomy (RPD), but data on its technical feasibility and clinical outcomes are limited.

Methods: We retrospectively reviewed 83 RPD patients utilizing the LP approach, dividing them into early (n = 42) and late (n = 41) groups to assess procedural maturity.

Pancreatectomies with vein resection: Two large institutions' experience of East and West.

Background: The effectiveness and preferred reconstruction methods of pancreatectomy associated with vein resection (PAVR) for pancreatic cancer, especially for the extensive portal vein/superior mesenteric vein (PV/SMV) resections (more than 4 cm), are still subjects of debate. The aim of this study is to evaluate the safety and feasibility of PAVR by analyzing data from two large institutions from different regions.

Methods: From 2008 to 2018, we identified consecutive series of patients with pancreatic cancer who underwent PAVR at Karolinska University Hospital (KUH), Sweden, and Cancer Institute Hospital, Japanese Foundation of Cancer Research (JFCR), Japan.

Clinical implications of disappearing pancreatic cancer liver metastases: Lessons from colorectal liver metastases.

Background: The efficacy of local control for pancreatic cancer liver metastases (PCLM), including surgical treatment, remains controversial, with no consensus on the management and clinical significance of disappearing liver metastases (DLMs). This study aimed to evaluate the clinical implications of DLMs in treating PCLM after multi-agent chemotherapy, utilizing contrast-enhanced imaging modalities.

Methods: A retrospective analysis was conducted on patients who underwent curative resection for pancreatic cancer with synchronous or metachronous liver metastases between 2014 and 2023.

Robot-Assisted CT-Guided Biopsy with an Artificial Intelligence-Based Needle-Path Generator: An Experimental Evaluation Using a Phantom Model.

Purpose: To investigate the feasibility of a robotic system with artificial intelligence-based lesion detection and path planning for computed tomography (CT)-guided biopsy compared with the conventional freehand technique.

Materials And Methods: Eight nodules within an abdominal phantom, incorporating the simulated vertebrae and ribs, were designated as targets. A robotic system was used for lesion detection, trajectory generation, and needle holder positioning.

Role of spin-orbit coupling for the band splitting in-Sb and-Bi on SiC(0001).

Monolayer atomic thin films of group-V elements have a high potential for application in spintronics and valleytronics because of their unique crystal structure and strong spin-orbit coupling. We fabricated Sb and Bi monolayers on a SiC(0001) substrate by the molecular-beam-epitaxy method and studied the electronic structure by angle-resolved photoemission spectroscopy (ARPES) and first-principles calculations. The fabricated Sb film shows the (√3 × √3)30° superstructure associated with the formation of-Sb, and exhibits a semiconducting nature with a band gap of more than 1.

Role of spin-orbit coupling for the band splitting in ⍺-Sb and ⍺-Bi on SiC(0001).

Monolayer atomic thin films of group-V elements have a high potential for application in spintronics and valleytronics because of their unique crystal structure and strong spin-orbit coupling. We fabricated Sb and Bi monolayers on a SiC(0001) substrate by the molecular-beam-epitaxy method and studied the electronic structure by angle-resolved photoemission spectroscopy (ARPES) and first-principles calculations. The fabricated Sb film shows the (√3×√3)R30º superstructure associated with the formation of ⍺-Sb, and exhibits a semiconducting nature with a band gap of more than 1.

Technical Guidelines for Safe Mesojejunum Dissection During Pancreaticoduodenectomy: Unveiling Critical Techniques in a Complex Procedure.

Background: Pancreaticoduodenectomy (PD) is a complex procedure involving the dissection of the superior mesenteric artery and vein. However, a safe and standardized technique for dissecting the jejunal veins (JVs) in the mesojejunum during PD remains elusive.

Methods: We retrospectively analyzed 198 patients who underwent open PD with mesojejunum dissection using an anterior artery-first approach and evaluated anatomical variations in the first JV trunk (FJVT) and its tributaries.

Strategies for Recurrent Colorectal Liver Metastases Based on Prognostic Factors and Resectability: Potential Benefit of Multidisciplinary Treatment.

Background: Colorectal liver metastasis (CLM) is classified into technical and oncologic categories, with recommended treatments for each resectability category. However, the classification of recurrent CLM has not been established to date.

Methods: This study evaluated patients with CLM who underwent initial liver resection between 2006 and 2020 and subsequently experienced liver recurrence.

Posthepatectomy Liver Failure in Patients with Splenomegaly Induced by Induction Chemotherapy for Colorectal Liver Metastases.

Purpose: With advances in chemotherapy, conversion surgery is often performed for initially unresectable colorectal cancer liver metastasis (CLM). However, unexpected posthepatectomy liver failure (PHLF) is sometimes associated with chemotherapy-associated liver injuries following long-term chemotherapy. We aimed to identify predictive factors for PHLF after conversion surgery for initially unresectable CLM.