Mesenchymal stromal cells for the prophylaxis of graft-versus-host disease after hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials.

Background: Mesenchymal stromal cells (MSCs) have emerged as a potential alternative therapeutic strategy for the prophylaxis of graft-versus-host disease (GVHD) in patients undergoing hematopoietic stem cell transplantation (HSCT).

Research Design And Methods: This meta-analysis included eight randomized controlled trials (RCTs) involving 570 patients. The primary outcomes assessed were overall survival (OS), the development of acute GVHD(aGVHD), and chronic GVHD (cGVHD).

A rare case of Dyke-Davidoff-Masson syndrome with concurrent metabolic syndrome.

Dyke-Davidoff-Masson syndrome (DDMS) is a rare neurological condition resulting from prenatal or early childhood brain injury, characterized by seizures, hemiparesis, facial asymmetry, and intellectual disability, with imaging findings including cerebral hemiatrophy, calvarial thickening, and mastoid cell hyperpneumatization. We present the case of a 13-year-old male who exhibited recurrent convulsive seizures predominantly affecting his left side. MRI revealed right-sided cerebral hemiatrophy with ipsilateral calvarial thickening and mastoid hyperpneumatization, consistent with DDMS.

Evaluation of Inflammatory Markers and Clinical Outcomes in Patients with Acute Pancreatitis: A Prospective Cohort Study.

Background: Acute pancreatitis (AP) is a sudden inflammatory process of the pancreas that can lead to varying degrees of severity, ranging from mild discomfort to life-threatening conditions. Identifying key inflammatory markers at an early stage is crucial to predicting clinical outcomes and improving management.

Objective: This study aims to evaluate the association between inflammatory markers-C-reactive protein (CRP), serum amylase, and white blood cell (WBC) count-and clinical outcomes in patients with acute pancreatitis.

Cardiac amyloidosis in severe aortic stenosis patients: an updated review unraveling their complex interplay.

Aortic stenosis (AS) and cardiac amyloidosis (CA) often coexist in elderly patients, complicating diagnosis and treatment. AS is characterized by the narrowing of the aortic valve, leading to left ventricular outflow obstruction, primarily due to age-related calcification and congenital defects. CA, the most common cause of restrictive cardiomyopathy, results from amyloid protein deposits in the myocardium, causing diastolic dysfunction.

Sleep patterns and their correlation with cardiovascular health in the general population: A cross-sectional study.

Sleep patterns, including duration and quality, are closely linked to cardiovascular health. This cross-sectional study of 100 participants aged 30-65 years assessed sleep patterns using validated questionnaires and measured cardiovascular health using the Framingham Risk Score. Short sleep duration (<6 hours) and poor sleep quality were significantly associated with higher cardiovascular risk (p < 0.