Publications by authors named "Suraj Kumar Singh"

Understanding how climate variability and anthropogenic activities reshape ecosystems is essential for sustainable development in environmentally sensitive regions. This study analyses land use changes and vegetation trends in western Jharkhand, India, using multi-source satellite data from 2000 to 2020. The findings reveal that agricultural land expanded from 53.

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Article Synopsis
  • - Pancreatic β-cell transplantation is a promising therapy for type I diabetes, but is limited by a shortage of human pancreas donors, driving research into stem cell alternatives for insulin-producing cells.
  • - The study created a novel MXene composite nanofibrous scaffold to support the growth and differentiation of stem cells into pancreatic β-cells, demonstrating superior properties like a porous structure and increased hydrophilicity.
  • - Results showed that stem cells grown on the MXene scaffold developed stronger characteristics of pancreatic β-cells and produced more insulin in response to glucose, suggesting this approach could improve diabetes treatments.
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Dengue fever (DF) is a pervasive public health concern in tropical climates, with densely populated regions, such as India, disproportionately affected. Addressing this issue requires a multifaceted understanding of the environmental and sociocultural factors that contribute to the risk of dengue infection. This study aimed to identify high-risk zones for DF in Jaipur, Rajasthan, India, by integrating physical, demographic, and epidemiological data in a comprehensive risk analysis framework.

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The selection of an appropriate scaffold is imperative for the successful development of alternative animal protein in the form of cultured meat or lab-grown meat. Decellularized tissues have been suggested as a potential scaffold for cultured meat production owing to their capacity to support an optimal environment and niche conducive to cell proliferation and growth. This approach facilitates the systematic development of 3D tissues in the laboratory.

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Frequent floods are a severe threat to the well-being of people the world over. This is particularly severe in developing countries like India where tropical monsoon climate prevails. Recently, flood hazard susceptibility mapping has become a popular tool to mitigate the effects of this threat.

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Article Synopsis
  • The study focuses on generating goat-induced pluripotent stem cells (giPSCs) using episomal vectors carrying human pluripotent genes, which enhances their scientific applications in areas like cellular agriculture and cloning.
  • Traditional methods for creating giPSCs are complicated and inefficient, prompting researchers to explore a simpler, non-enzymatic method for isolating goat dermal fibroblast cells.
  • The resulting giPS-like colonies demonstrated characteristics of pluripotency, including positive staining for alkaline phosphatase and the formation of embryoid body-like aggregates, indicating a promising approach for efficient giPSC generation.
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Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the destruction of pancreatic β-cells, leading to insulin deficiency. Insulin replacement therapy is the current standard of care for T1D, but it has significant limitations. However, stem cell-based replacement therapy has the potential to restore β-cell function and achieve glycaemic control eradicating the necessity for drugs or injecting insulin externally.

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Introduction: Despite the advancements in perinatal care in past decades, perinatal asphyxia remains a serious problem leading to significant perinatal morbidity and mortality. Therefore, foetal monitoring during the intrapartum period is of paramount importance. Among various methods of fetal monitoring, cardiotocography is a form of electronic foetal monitoring in which there is simultaneous recording of foetal heart rate and uterine contractions.

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Wound healing responses play a major role in chronic inflammation, which affects millions of people around the world. One of the daunting tasks of creating a wound-healing drug is finding equilibrium in the inflammatory cascade. In this study, the molecular and cellular mechanisms to regulate wound healing are explained, and recent research is addressed that demonstrates the molecular and cellular events during diabetic wound healing.

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Inland water plants, particularly those that thrive in shallow environments, are vital to the health of aquatic ecosystems. Water hyacinth is a typical example of inland species, an invasive aquatic plant that can drastically alter the natural plant community's floral diversity. The present study aims to assess the impact of water hyacinth biomass on the floristic characteristics of aquatic plants in the Merbil wetland of the Brahmaputra floodplain, NE, India.

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In vitro meat production via stem cell technology and tissue engineering provides hypothetically elevated resource efficiency which involves the differentiation of muscle cells from pluripotent stem cells. By applying the tissue engineering technique, muscle cells are cultivated and grown onto a scaffold, resulting in the development of muscle tissue. The studies related to in vitro meat production are advancing with a seamless pace, and scientists are trying to develop various approaches to mimic the natural meat.

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Satellite remote sensing and geographic information system (GIS) have revolutionalized the mapping, quantifying, and assessing the land surface processes, particularly analyzing the past and future land use-land cover (LULC) change patterns. Worldwide river basins have observed enormous changes in the land system dynamics as a result of anthropogenic factors such as population, urbanization, development, and agriculture. As is the scenario of various other river basins, the Brahmaputra basin, which falls in China, Bhutan, India, and Bangladesh, is also witnessing the same environmental issues.

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A common phenomenon associated with alluvial rivers is their meander evolution, eventually forming cutoffs. Point bar deposits and ox-bow lakes are the products of lateral bend migration and meander cutoff. The present study focuses on identifying the meanders of River Manu and their cutoffs.

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Mesenchymal stem cell (MSC)-based therapy and tissue repair necessitate the use of an ideal clinical biomaterial capable of increasing cell proliferation and differentiation. Recently, MXenes 2D nanomaterials have shown remarkable potential for improving the functional properties of MSCs. In the present study, we elucidated the potential of TiCTx MXene as a biomaterial through its primary biological response to human Wharton's Jelly MSCs (hWJ-MSCs).

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Globally, the COVID-19 pandemic has become a threat to humans and to the socioeconomic systems they have developed since the industrial revolution. Hence, governments and stakeholders call for strategies to help restore normalcy while dealing with this pandemic effectively. Since till now, the disease is yet to have a cure; therefore, only risk-based decision making can help governments achieve a sustainable solution in the long term.

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Glioblastoma is highly recurrent and aggressive tumor with poor prognosis where existence of glioma stem cell (GSCs) population is well established. The GSCs display stem cell properties such as self-renewable, proliferation and therapeutic resistance which contribute to its role in tumor progression, metastasis and recurrence. Cancer stem cells (CSCs) can also be induced from non-stem cancer cells in response to radio/chemotherapy that further contribute to cancer relapse post therapy.

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Article Synopsis
  • Mitochondria play a critical role in maintaining cellular balance and influence cell growth and death, with their dysfunction linked to various diseases, including colorectal cancer (CRC).
  • The study focuses on how mitochondria function differently in CRC cells based on their metastatic potential, showing that low metastatic cells are resistant to oxidative stress but have impaired mitochondrial function, while high metastatic cells benefit from a properly functioning mitochondrial complex I (C-I).
  • Inhibiting C-I in high metastatic cells increases their susceptibility to cell death and reduces metastatic signaling, suggesting that targeting C-I could be a promising strategy in developing treatments for aggressive cancer types.
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Three-dimensional spheroids are a reliable model to study tumor biology and drug toxicity. However, inconsistencies exist in terms of seeding cell density that governs spheroid size and shape, influencing the experimental outcome. We investigated the effect of varying cell densities using glioblastoma cells on tumorsphere formation and their responsiveness to drug treatment.

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The novel coronavirus (COVID-19) has unleashed havoc across different countries and was declared a pandemic by the World Health Organization. Since certain evidences indicate a direct relationship of various viruses with the weather (temperature in particular), the same is being speculated about COVID-19; however, it is still under investigation as the pandemic is advancing the world over. In this study, we tried to analyze the spread of COVID-19 in the Indian subcontinent with respect to the local temperature regimes from March 9, 2020, to May 27, 2020.

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The baculovirus expression vector system (BEVS) is an emerging tool for the production of recombinant proteins, vaccines and bio-pesticides. However, a system-level understanding of the complex infection process is important in realizing large-scale production at a lower cost. The entire baculovirus infection process is summarized as a combination of various modules and the existing mathematical models are discussed in light of these modules.

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