Electroencephalogram Changes After Virtual Reality-Based Cognitive Behavioral Therapy for Panic Disorder.

Background: Cognitive behavioral therapy (CBT) for panic disorder involves training to cope with anxiety and panic attacks effectively. Recently, CBT, when integrated with anxiety-inducing virtual reality (VR) scenarios, has been utilized to treat panic disorder. This study aimed to investigate the neurophysiological impacts of VR-enhanced CBT in the treatment of panic disorder.

Development and Validation of Pneumonia Patients Prognosis Prediction Model in Emergency Department Disposition Time.

This study aimed to develop and evaluate an artificial intelligence model to predict 28-day mortality of pneumonia patients at the time of disposition from emergency department (ED). A multicenter retrospective study was conducted on data from pneumonia patients who visited the ED of a tertiary academic hospital for 8 months and from the Medical Information Mart for Intensive Care (MIMIC-IV) database. We combined chest X-ray information, clinical data, and CURB-65 score to develop three models with the CURB-65 score as a baseline.

Clustering Voice of the Customer Insights: Identifying Key Needs for AI-Based Early Warning System.

In this study, we analyzed voice of customer (VOC) data for an AI-based early warning system from healthcare providers using the BERTopic framework for effective topic modeling. A preprocessing pipeline was implemented, incorporating techniques such as lowercasing, stopword removal, and tokenization to prepare the text for analysis. To refine the model's performance, hyperparameter optimization was conducted using Optuna, with a primary focus on maximizing the Silhouette Score and minimizing the Davies-Bouldin Index, while also assessing the diversity of the generated topics.

Improving CPR Predictive Model in ED: The Role of Initial Data and KTAS.

This study develops a CPR prediction model using initial admission data in the emergency department. We retrospectively analyzed EMR data from Severance Hospital (2018-2022), excluding patients aged under 18 or without initial vital signs and KTAS, and those with DNR orders. We developed and compared two models: one using patient information and initial vital signs and another incorporating KTAS.

Prediction of microsatellite-stable/epithelial-to-mesenchymal transition molecular subtype gastric cancer using CT radiomics and clinicopathologic factors.

Objectives: This study aimed to develop a predictive model for the microsatellite-stable (MSS)/epithelial-to-mesenchymal transition (EMT) subtype of gastric cancer (GC) using computed tomography (CT) radiomics and clinicopathological factors.

Materials And Methods: This retrospective study included 418 patients with GC who underwent primary resection and transcriptome analysis with microarray between October 1995 and May 2008. Using preoperative CT images, radiomic features from the volume of interest in the portal venous phase images were extracted.

Complete genome sequence of ATCC25418.

causes carnation bacterial wilt disease. We report the complete genome sequence of ATCC25418. There are two circular chromosomes with a total length of 6,589,249 bp, and the total GC content is 64.

Distribution of Vegetation and Soil Seed Banks Across Habitat Types in Paddy Fields Under Different Farming Practices.

Paddy field ecosystems are crucial for crop production, biodiversity conservation, and ecosystem services. Although previous studies have examined paddy field biodiversity, few have addressed how the distribution and species richness of vegetation and soil seed banks are regulated. This study investigated the distribution of wetland plants and soil seed banks in paddy fields across diverse habitat types and identified factors influencing their patterns.

The Inferior Cerebellar Peduncle Sign: A Novel Imaging Marker for Differentiating Multiple System Atrophy Cerebellar Type from Spinocerebellar Ataxia.

Background And Purpose: The hot cross bun (HCB) sign is a hallmark feature of multiple system atrophy with predominant cerebellar ataxia (MSA-C), typically observed in advanced stages of the disease; however, it can also present in other conditions such as spinocerebellar ataxia (SCA), making the differentiation challenging. The middle cerebellar peduncle (MCP) sign may be observed in various medical conditions and in healthy individuals. We hypothesized that the inferior cerebellar peduncle (ICP), known to be affected in MSA-C, may exhibit hyperintensity on FLAIR imaging, potentially aiding in differentiating MSA-C from SCA.

Control of Cucumber Powdery Mildew Using Resistant Cultivars and Organic Agricultural Materials.

This study evaluated the efficacy of various inorganic materials, biological control agents, organic agricultural materials (OAMs), and essential oils for controlling cucumber powdery mildew (CPM) under greenhouse conditions. Treatments included silicate, bicarbonate, copper sulfate, sulfur-based compounds, KB-401, M27, Bordeaux mixtures, chitosan combined with oxidated copper salt, chitooligosaccharides, and essential oils such as castor and rapeseed oil with lecithin. Results demonstrated that Bordeaux mixtures, particularly Bordeaux Mixture I, and sulfur-based compounds provided the most reliable CPM control among inorganic materials.

Development of a flexible feature selection framework in radiomics-based prediction modeling: Assessment with four real-world datasets.

There are several important challenges in radiomics research; one of them is feature selection. Since many quantitative features are non-informative, feature selection becomes essential. Feature selection methods have been mixed with filter, wrapper, and embedded methods without a rule of thumb.

Preoperative prediction of early recurrence in resectable pancreatic cancer integrating clinical, radiologic, and CT radiomics features.

Objectives: To use clinical, radiographic, and CT radiomics features to develop and validate a preoperative prediction model for the early recurrence of pancreatic cancer.

Methods: We retrospectively analyzed 190 patients (150 and 40 in the development and test cohort from different centers) with pancreatic cancer who underwent pancreatectomy between January 2018 and June 2021. Radiomics, clinical-radiologic (CR), and clinical-radiologic-radiomics (CRR) models were developed for the prediction of recurrence within 12 months after surgery.

Effects of the Electrical Properties of SnO and C60 on the Carrier Transport Characteristics of p-i-n-Structured Semitransparent Perovskite Solar Cells.

Recently, metal halide perovskite-based top cells have shown significant potential for use in inexpensive and high-performance tandem solar cells. In state-of-the-art p-i-n perovskite/Si tandem devices, atomic-layer-deposited SnO has been widely used as a buffer layer in the top cells because it enables conformal, pinhole-free, and highly transparent buffer layer formation. In this work, the effects of various electrical properties of SnO and C60 layers on the carrier transport characteristics and the performance of the final devices were investigated using a numerical simulation method, which was established based on real experimental data to increase the validity of the model.

Weight loss from diagnosis of Crohn's disease to one year post-diagnosis results in earlier surgery.

Malnutrition might play a key role in the prognosis of patients with Crohn's disease (CD). The aim of this study was to explore the impact of weight loss from diagnosis of CD to one-year post-diagnosis on disease prognosis in terms of surgery. Patients who were diagnosed with CD at Samsung Medical Center between 1995 to 2020 were included in this study.

Genomic Analysis of the Carrot Bacterial Blight Pathogen Xanthomonas hortorum pv. carotae in Korea.

Bacterial leaf blight of carrots caused by Xanthomonas hortorum pv. carotae (Xhc) is an important worldwide seed-borne disease. In 2012 and 2013, symptoms similar to bacterial leaf blight were found in carrot farms in Jeju Island, Korea.

Effects of Ti-doping amount and annealing temperature on electrochromic performance of sol-gel derived WO.

Fine control of structural and morphological features in electrochromic materials is of paramount importance for realizing practical electrochromic devices (ECDs), which can dynamically adjust indoor light and temperature of buildings. To this end, herein we investigate impacts of two variants such as Ti-doping amount and the annealing temperature on physical and chemical properties of sol-gel derived electrochromic WO films. We use a wide range of titanium coupling agents (TCAs) as Ti-dopants ranging from 0 wt% to 20 wt% and vary the annealing temperature between 200 °C and 400 °C with 50 °C interval.

Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study.

We investigated the clinical relevance of urinary cytokines/chemokines reflecting intrarenal immunologic micromilieu as prognostic markers and the optimal measurement timing after living donor kidney transplantation (LDKT). This prospective cohort study included 77 LDKT patients who were followed for ≥ 5 years. Patients were divided into control (n = 42) or acute rejection (AR, n = 35) group.

Discovery of μ,δ-Opioid Receptor Dual-Biased Agonists That Overcome the Limitation of Prior Biased Agonists.

Morphine is widely used in pain management although the risk of side effects is significant. The use of biased agonists to the G protein of μ-opioid receptors has been suggested as a potential solution, although oliceridine and PZM21 have previously failed to demonstrate benefits in clinical studies. An amplification-induced confusion in the process of comparing G protein and beta-arrestin pathways may account for previously biased agonist misidentification.

Validation of the GenesWell BCT Score in Young Asian Women With HR+/HER2- Early Breast Cancer.

Background: The prognostic or predictive value of commonly used multigene assays in young patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) early breast cancer is unclear. In this study, we assessed the prognostic value of the GenesWell BCT assay according to age group.

Methods: We identified patients with pN0-1, HR+/HER2- breast cancer in a prospective cohort of women who underwent surgery between 2005 and 2017.

Quorum Sensing System Affects the Plant Growth Promotion Traits of GS2.

Quorum sensing (QS) enables bacteria to organize gene expression programs, thereby coordinating collective behaviors. It involves the production, release, and population-wide detection of extracellular signaling molecules. The cellular processes regulated by QS in bacteria are diverse and may be used in mutualistic coordination or in response to changing environmental conditions.

An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H--Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target.

Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in many cancerous or transformed cells and some stromal cells in the tumor microenvironment. Persistent STAT3 activation in malignant cells stimulates proliferation, survival, angiogenesis, invasion, and tumor-promoting inflammation. STAT3 undergoes activation through phosphorylation on tyrosine 705, which facilitates its dimerization.

Prediction of Cardiac Arrest in the Emergency Department Based on Machine Learning and Sequential Characteristics: Model Development and Retrospective Clinical Validation Study.

Background: The development and application of clinical prediction models using machine learning in clinical decision support systems is attracting increasing attention.

Objective: The aims of this study were to develop a prediction model for cardiac arrest in the emergency department (ED) using machine learning and sequential characteristics and to validate its clinical usefulness.

Methods: This retrospective study was conducted with ED patients at a tertiary academic hospital who suffered cardiac arrest.

Predicting Adverse Outcomes for Febrile Patients in the Emergency Department Using Sparse Laboratory Data: Development of a Time Adaptive Model.

Background: A timely decision in the initial stages for patients with an acute illness is important. However, only a few studies have determined the prognosis of patients based on insufficient laboratory data during the initial stages of treatment.

Objective: This study aimed to develop and validate time adaptive prediction models to predict the severity of illness in the emergency department (ED) using highly sparse laboratory test data (test order status and test results) and a machine learning approach.

Enhancing membrane modulus of giant unilamellar lipid vesicles by lateral co-assembly of amphiphilic triblock copolymers.

We report a facile, but robust approach to fabricate structurally stable giant unilamellar vesicles (GUVs), on which a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayer membrane was made rigid by introducing amphiphilic block polymers. Particularly, we found that lateral co-assembly of an amphiphilic triblock copolymer (ATC) structured with a hydrophobic middle block and long molecular weight (20 K g/mol) hydrophilic end blocks remarkably enhanced the stretching modulus (k) of GUVs. When the membrane composition was optimized, the k value of ATC-hybridized GUVs increased to 6.

Comprehensive Clinical and Genetic Characterization of Hyperprogression Based on Volumetry in Advanced Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitor.

Introduction: Hyperprogressive disease (HPD), characterized by accelerated tumor progression, has been proposed as a new pattern of progression after immune checkpoint inhibitor (ICI) treatment. The aim of this study was to describe the characteristics of HPD and investigate its predictive markers.

Methods: Clinical and radiological findings of 335 patients with advanced NSCLC treated with ICI monotherapy were retrospectively analyzed.