Inactivation of BSL-2 and BSL-3 human pathogens using FATHHOME's Trinion Disinfector: A rapid and eco-friendly ozone-based dry disinfection approach.

The role of personal protective equipment (PPE) in protecting against exposure to infectious agents and toxic chemicals is well-established. However, the global surge in PPE demand during the pandemic exposed challenges, including shortages and environmental impacts from disposable waste. Developing effective, scalable, and sustainable decontamination methods for the reuse of PPE is essential.

Biostimulation through natural biological inputs on fruiting, nutrient availability and rhizosphere microbiome in legume intercropped 'Sweet Charlie' strawberry (Fragaria × Ananassa Duch.).

Conventional agricultural practices have been associated with detrimental effects such as soil degradation, reduction in biodiversity, environmental contamination due to agrochemical use, and a decrease in the nutritional quality of crops. These challenges necessitate a transition toward sustainable and ecologically sound farming systems. Natural Farming, the regenerative agriculture has shown promising results in restoring soil organic carbon, enhancing microbial biomass and enzymatic activity, improving water retention, and supporting nutrient cycling through natural inputs.

Developmental biology and population growth parameters along with predatory potential of (Neuroptera: Chrysopidae) against (Hemiptera: Aphididae).

The green lacewing (Esben-Peterson) (Neuroptera: Chrysopidae), a polyphagous predator, is an effective biocontrol agent against various aphid species. Its efficacy was assessed against (Hemiptera: Aphididae), a major pest of peach and nectarine orchards. This study investigates the developmental biology, population growth parameters, host-kill dynamics, and aphid consumption by when fed on .

Evidence of transitioning apple farming to an agro-ecological model in Himachal Pradesh.

Agro-ecological farming practices that integrate economic viability and environmental resilience, based on principles designed to support optimal food and nutritional security in farming systems. This study compares Natural Farming (NF) and Conventional Farming (CF) in apple orchards of Himachal Pradesh by using agro-ecological indicators to assess soil health, pest management, and profitability. The research was conducted across the High Hills Temperate Wet (Zone III) and Dry Temperate High Hills (Zone IV).

Host range expansion of Helicoverpa armigera to apple orchards in the Himalayan region.

Helicoverpa armigera is an important polyphagous pest of agriculture worldwide. In the current study, the pest has been found to diversify its host range to apple in Himachal Pradesh (India). Currently, H.

Feeding potential and functional response of (Mulsant) against potato aphid, Thomas (Hemiptera: Aphididae).

(Mulsant) (Coccinellidae: Coleoptera) is a highly efficient predator of sap-sucking insect pests due to its high feeding capacity and broad prey range. The present investigation was carried out to find out the feeding potential and functional response of fed on different densities of (Thomas) (Aphididae: Hemiptera) nymphs in the condition with the overarching objective of appraising the ladybird beetle's potential as a distinguished biological control agent. The newly emerged coccinellid grubs of a particular stage were reared individually on Petri plates with a known number of nymphs of a particular stage.

Characterization of Human Cytomegalovirus (HCMV) Long Non-Coding RNA1.2 During Lytic Replication.

During lytic replication of human cytomegalovirus (HCMV), the most abundant viral transcripts are long non-coding RNAs (lncRNAs). Viral lncRNAs can have a variety of functions, some of which are necessary for viral production and the modulation of host processes during infection. HCMV produces four lncRNAs, Beta2.

Identifying the amino acid domains of ORF59 responsible for interactions with ORF57 and PAN RNA during KSHV lytic replication.

Kaposi's sarcoma-associated herpesvirus (KSHV) DNA polymerase processivity factor, ORF59, is a lytic protein essential for viral DNA synthesis as part of the core replication complex. The multifunctional nature of ORF59 has prompted the investigation into its various functional domains. Prior studies of ORF59 have identified dimerization, DNA interaction, and polymerase interaction domains.

The cellular paraspeckle component SFPQ associates with the viral processivity factor ORF59 during lytic replication of Kaposi's Sarcoma-associated herpesvirus (KSHV).

Kaposi's sarcoma-associated herpesvirus (KSHV) relies on many cellular proteins to complete replication and generate new virions. Paraspeckle nuclear bodies consisting of core ribonucleoproteins splicing factor proline/glutamine-rich (SFPQ), Non-POU domain-containing octamer-binding protein (NONO), and paraspeckle protein component 1 (PSPC1) along with the long non-coding RNA NEAT1, form a complex that has been speculated to play an important role in viral replication. Paraspeckle bodies are multifunctional and involved in various processes including gene expression, mRNA splicing, and anti-viral defenses.

Demographic analysis and biotic potential of (J.E. Smith) (Lepidoptera: Noctuidae) on pea.

The fall armyworm (FAW), (J.E. Smith) (Lepidoptera: Noctuidae) is a highly destructive polyphagous pest that primarily damages maize.

Unraveling the enigma of root-knot nematodes: from origins to advanced management strategies in agriculture.

Integrated management strategies, including novel nematicides and resilient cultivars, offer sustainable solutions to combat root-knot nematodes, crucial for safeguarding global agriculture against persistent threats. Root-knot nematodes (RKN) pose a significant threat to a diverse range of host plants, with their obligatory endoparasitic nature leading to substantial agricultural losses. RKN spend much of their lives inside or in contact by secreting plant cell wall-modifying enzymes resulting in the giant cell development for establishing host-parasite relationships.

Co-Expression of Niemann-Pick Type C1-Like1 (NPC1L1) with ACE2 Receptor Synergistically Enhances SARS-CoV-2 Entry and Fusion.

The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into human embryonic kidney (HEK293T) cells has been shown to be a cholesterol-rich, lipid raft-dependent process. In this study, we investigated if the presence of a cholesterol uptake receptor Niemann-pick type c1-like1 (NPC1L1) impacts SARS-CoV-2 cell entry. Initially, we utilized reporter-based pseudovirus cell entry assays and a spike (S) glycoprotein-mediated cell-to-cell fusion assay.

SARS-CoV-2 superinfection in CD14 monocytes with latent human cytomegalovirus (HCMV) promotes inflammatory cascade.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), has posed significant challenges to global health. While much attention has been directed towards understanding the primary mechanisms of SARS-CoV-2 infection, emerging evidence suggests co-infections or superinfections with other viruses may contribute to increased morbidity and mortality, particularly in severe cases of COVID-19. Among viruses that have been reported in patients with SARS-CoV-2, seropositivity for Human cytomegalovirus (HCMV) is associated with increased COVID-19 risk and hospitalization.

Microbiological acceptance criteria, specifications of herbal drugs and herbal drug preparations in various pharmacopoeias: a global scenario.

Purpose: A pharmacopoeia is a compendium of guidelines and criteria for drug quality. It was established by a national or regional entity and has legal significance. This applies to administration of drugs in a particular nation or region.

G-Quadruplexes in the Regulation of Viral Gene Expressions and Their Impacts on Controlling Infection.

G-quadruplexes (G4s) are noncanonical nucleic acid structures that play significant roles in regulating various biological processes, including replication, transcription, translation, and recombination. Recent studies have identified G4s in the genomes of several viruses, such as herpes viruses, hepatitis viruses, and human coronaviruses. These structures are implicated in regulating viral transcription, replication, and virion production, influencing viral infectivity and pathogenesis.

Semiochemical based integrated livestock pest control.

The role of arthropods as livestock pests has been well established. Besides their biting habits causing nuisance in animals; they are important vectors for transmission of economically important livestock diseases worldwide. Various pests and vector control managemental programs that also make use of chemicals have variable success rates.

Nucleolin Regulates the Expression of Kaposi's Sarcoma-Associated Herpesvirus' Latency-Associated Nuclear Antigen through G-Quadruplexes in the mRNA.

Kaposi's sarcoma-associated herpesvirus (KSHV) establishes life-long latent infection and is linked to several human malignancies. Latency-associated nuclear antigen (LANA) is highly expressed during latency, and is responsible for the replication and maintenance of the viral genome. The expression of LANA is regulated at transcriptional/translational levels through multiple mechanisms, including the secondary structures in the mRNA sequence.

Polyaniline/Titania Nanotube-Based Biosensor Strip for Sensitive and Specific Electrochemical Detection of SARS-CoV-2.

This study showcases the creation of a biosensor strip designed for the rapid, precise, and highly sensitive electrochemical detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These biosensor strips were crafted by affixing a monoclonal antibody (mAb) specific to SARS-CoV-2 onto the surface of a commercially screen-printed carbon electrode (SPCE) modified with polyaniline-titania nanotubes (PANi-TNT). The transportable sensing device was constructed by pairing the mAb functionalized strip with a portable potentiostat wirelessly connected to either a Windows or Android device.

"Effect of total phenol on the control of leafminer () infestation in Pea plants".

To determine how vulnerable various pea genotypes are to leafminer infestation, a field experiment was conducted. On the basis of the presence of mines on five randomly selected leaflets from the upper, middle and lower parts of the plant, observations of larvae were made throughout the growing season. The total phenols were determined using the method described by Bray and Thorpe (1954, Analysis of phenolic compounds of interest in metabolism.

G-quadruplexes of KSHV oriLyt play important roles in promoting lytic DNA replication.

Biological processes originating from the DNA and RNA can be regulated by the secondary structures present in the stretch of nucleic acids, and the G-quadruplexes are shown to regulate transcription, translation, and replication. In this study, we identified the presence of multiple G-quadruplex sites in the region (oriLyt) of Kaposi's sarcoma-associated herpesvirus (KSHV) DNA, which is essential for DNA replication during the lytic cycle. We demonstrated the roles of these G-quadruplexes through multiple biochemical and biophysical assays in controlling replication and efficient virus production.

Effect of prey density on the performance of and its predation rate against the cabbage aphid, (L.).

(F.) (Diptera: Syrphidae) is the most abundant syrphid fly which is distributed worldwide and is the sole predator of aphids. Therefore, the present study was conducted to evaluate the predation rate and functional response of against the cabbage aphid, (L.

Functional attributes of bioactive peptides of bovine milk origin and application of approaches for peptide prediction and functional annotations.

Bovine milk peptides are the protein fragments with diverse bioactive properties having antioxidant, anticarcinogenic, other therapeutic and nutraceutical potentials. These peptides are formed in milk by enzymatic hydrolysis, gastrointestinal digestion and fermentation processes. They have significant health impact with high potency and low toxicity making them a suitable natural alternative for preventing and managing diseases.

Screening of SARS-CoV-2 antivirals through a cell-based RNA-dependent RNA polymerase (RdRp) reporter assay.

COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus-2) continues to pose an international public health threat and thus far, has resulted in greater than 6.4 million deaths worldwide. Vaccines are critical tools to limit COVID-19 spread, but antiviral drug development is an ongoing global priority due to fast-spreading COVID-19 variants that may elude vaccine efficacies.

Analysis of SARS-CoV-2 variants from patient specimens in Nevada from October 2020 to August 2021.

In early 2020, the emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human population quickly developed into a global pandemic. SARS-CoV-2 is the etiological agent of coronavirus disease 2019 (COVID-19) which has a broad range of respiratory illnesses. As the virus circulates, it acquires nucleotide changes.

Significance of wastewater surveillance in detecting the prevalence of SARS-CoV-2 variants and other respiratory viruses in the community - A multi-site evaluation.

Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral genome in wastewater has proven to be useful for tracking the trends of virus prevalence within the community. The surveillance also provides precise and early detection of any new and circulating variants, which aids in response to viral outbreaks. Site-specific monitoring of SARS-CoV-2 variants provides valuable information on the prevalence of new or emerging variants in the community.