Serum proteomes and their prognostic values in sepsis patients admitted to a medical intensive care unit: a single-center study using SWATH-MS proteomics.

Background: Recent developments in proteomics suggest opportunities to understand the pathophysiological heterogeneity of sepsis and provide precision medicine tailored to individual patients. This study aims to evaluate the serum proteomic profiles of patients with sepsis using Sequential Window Acquisition of All Theoretical Mass Spectra proteomics and identify novel biomarkers for assessing sepsis severity and predicting patient outcomes in the ICU.

Methods: This retrospective cohort study included 217 adult patients diagnosed with bacterial sepsis who were admitted to a medical ICU at a single tertiary hospital between January 2011 and January 2020, along with 292 healthy controls.

Optimal time and volume of fluid resuscitation in patients with sepsis: a nationwide multicenter cohort study.

The optimal fluid resuscitation strategy for managing sepsis remains unknown. We aimed to examine the independent and joint associations of infusion time and volume of fluid resuscitation on mortality in patients with sepsis. We analyzed adult patients with sepsis who received > 20 mL/kg of fluid for initial resuscitation within 6 h after the start of fluid resuscitation from prospectively collected nationwide data at 15 hospitals in South Korea between September 2019 and December 2022.

Characterization and comparative analysis of saponins in various spinach (Spinacia oleracea L.) cultivars according to growing seasons.

Spinach is valued for its nutritional benefits, containing essential vitamins, minerals, and functional compounds that support health, particularly through anti-inflammatory and immunomodulatory properties. However, the specific metabolites responsible for these effects remain unidentified. This study quantified total saponin content in 15 spinach cultivars harvested in different seasons, expressed on a dry matter basis (mg/g D.

Physical and Cognitive Impairments at ICU Discharge are Associated with High Long-Term Mortality in ICU Survivors with Solid Malignancies: A Retrospective Cohort Study.

Background: Many ICU survivors experience post-ICU physical, cognitive, or mental impairments. In ICU survivors with solid malignancies, post-ICU impairments can impede further cancer treatments and negatively impact their outcomes. This study aimed to investigate post-ICU mortalities and their risk factors at ICU discharge in ICU survivors with solid malignancies.

Trophic niche partitioning among three sympatric anuran species in a South Korean forest ecosystem based on stable isotope analysis.

Stable isotope analysis (SIA) is a powerful tool for assessing resource use and trophic structure, enhancing understanding of coexistence mechanisms among sympatric species. In this study, we analyzed carbon (δ¹³C) and nitrogen (δ¹⁵N) stable isotopes in bone collagen of three coexisting anuran species-Bombina orientalis, Rana uenoi, and R. huanrenensis-from South Korean forest to evaluate their isotopic niches, resource partitioning, and within-population variation.

Novel Autologous Regulatory T-Cell Therapy Ameliorates DSS-Induced Colitis in Humanized Mice.

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with a complex immune-mediated pathogenesis. The efficacy of human-specific cellular immunotherapies and biological medications cannot be accurately evaluated using traditional murine IBD models. Therefore, a humanized mouse model of IBD is necessary.

The Grief Navigation Trial: A multi-site pragmatic comparative effectiveness trial of two interventions to support parents after their child's unexpected or traumatic death.

Background: In the US, ~60,000 people <25 years old die annually. Forty-five percent of pediatric deaths occur traumatically, and the parents' or caregivers' (hereafter 'parents') sole contact with the healthcare system is often the coroner or medical examiner (ME). Parents experience mental and physical health problems following their child's death.

Physiological effects of bi-level high-flow nasal cannula in healthy individuals: a proof of concept trial.

Background: High-flow nasal cannula (HFNC) delivers a continuous, unidirectional high flow of oxygen (Uniflow) throughout the respiratory cycle. Despite its positive pressure effects in the nasopharynx, the persistent high flow during expiration imposes additional work of breathing and disrupts the patient's neural respiratory cycle. We devised a bi-level high-flow system (Biflow) allowing separate flow rate adjustments for inspiration and expiration.

The impact of withholding and withdrawal life-sustaining treatment issues on patients with sepsis: a prospective, nationwide, multicenter cohort study.

Approximately half of the patients with sepsis require intensive care unit (ICU) management and their mortality rate remains high. The concept of withholding and withdrawal life-sustaining treatment (WWLST) issue was introduced to limit the suffering of critically ill patients. However, little is known about the characteristics and outcomes of WWLST in patients with sepsis.

Impact of Elevated Troponin Level at the Time of Sepsis Recognition on the Clinical Outcomes: A Propensity Score-Matched Cohort Study.

Background: Sepsis-induced cardiac dysfunction, known as septic cardiomyopathy, is a common complication associated with increased mortality. Cardiac troponins serve as markers for myocardial injury and are frequently elevated in patients with sepsis. However, the role of troponin elevation at sepsis recognition in risk stratification remains controversial.

Inhibition of 11β-hydroxysteroid dehydrogenase 1 alleviates pulmonary fibrosis through inhibition of endothelial-to-mesenchymal transition and M2 macrophage polarization by upregulating heme oxygenase-1.

The intracellular enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) catalyzes the interconversion of active glucocorticoid (cortisol) and its intrinsically inert form (cortisone) in metabolic tissues. Although 11βHSD1 is considered a promising therapeutic target in metabolic disorders such as type 2 diabetes, obesity, and nonalcoholic steatohepatitis because of its hepatic functions, its roles in other tissues have received less attention. In this study, we show that the 11βHSD1-specific inhibitor J2H-1702 facilitates the reversion of endothelial-to-mesenchymal transition in multicellular lung spheroid models encapsulating the complex crosstalk among lung cancer cells, vascular endothelial cells, and macrophages.

Polygenic Risk and Cardiovascular Event Risk in Patients With Atrial Fibrillation With Low to Intermediate Stroke Risk.

Background: The clinical utility of the polygenic risk score in predicting cardiovascular events in patients with atrial fibrillation (AF) has not yet been established. This study aimed to determine whether the polygenic risk score for AF might be useful in the risk stratification of AF-related cardiovascular events.

Methods And Results: This study included 9597 oral anticoagulation-naive patients with AF with a CHADS-VA (congestive heart failure; hypertension; age ≥75 years; diabetes; prior stroke or transient ischemic attack or thromboembolism; vascular disease; and age 65-74 years) score of 0 or 1 from the UK Biobank.

Description of sp. nov., isolated from deep seawater of the Amundsen Sea (Antarctica), and reclassification of Liu . 2022 as a later heterotypic synonym of Tareen . 2022.

Gram-stain-negative, aerobic, rod-shaped bacterial strains, designated HL-TH1 and HL-TH5, were isolated from deep seawater (1127 m depth) of the Amundsen Sea, Antarctica. Phylogenetic analyses based on the 16S rRNA gene sequence revealed that strains HL-TH1 and HL-TH5 were members of the genus with close relatives GH25 (99.3%), NZ-96 (99.

Advancing the Study of Maternal Prenatal Stress Phenotypes and Infant Temperament Outcomes.

Exposure to the in utero environment provides offspring risk or protection with respect to postpartum development and health across the lifespan. We used latent profile analysis (LPA), considering self-report and physiological indicators to assess the influence of maternal prenatal stress/distress on infant temperament. We predicted that participants who reported greater prenatal stress/distress would have infants with less optimal temperament characteristics (e.

Epidemiology and risk factors of fungal pathogens in sepsis: a prospective nationwide multicenter cohort study.

Background: The incidence of sepsis with identified fungal pathogens is increasing and is associated with higher morbidity and mortality. Co-infection with fungal infections in COVID-19 patients is attracting clinical attention. This study examines the epidemiology, risk factors, and outcomes among sepsis patients with identified fungal pathogens.

Pediatric trauma transfer patients have low rates of additional traumatic injuries.

Background: Pediatric trauma patients often require interfacility transfer for subspecialty management of presumed isolated injuries. Understanding the frequency of additional injury in these low-acuity patients may improve resource utilization.

Methods: Pediatric trauma patients transferred to a level 1 trauma center in 2019 were compared by type of presenting injury in a retrospective review.

Serum miR-329-3p as a potential biomarker for poor ovarian response in an in vitro fertilization.

Objective: Several miRNAs have been identified as differentially expressed in patients with poor ovarian response (POR) compared to those with normal responses. This study aims to assess the potential of serum miR-329-3p as a biomarker for diagnosing POR.

Methods: We conducted a Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis to confirm the target genes of miR-329-3p.

Clinical characteristics and prognostic factors of sepsis in patients with malignancy.

Sepsis is a severe complication in patients with malignant tumors, leading to high mortality and increased need for intensive care. This study aimed to investigate the clinical characteristics and prognostic factors influencing sepsis outcomes in patients with malignant tumors. We included 4,858 patients with cancer diagnosed with sepsis between September 2019 and February 2020 whose data were collected from the Korean Sepsis Alliance, a nationwide multicenter cohort study.

Prognostic value of cardiac CT-derived RV dysfunction in lung transplantation candidates: A single-center retrospective study.

Background: There are no specific criteria for listing and prioritizing lung transplantation (LTx) candidates based on the severity of right ventricular (RV) dysfunction. We evaluated the prognostic value of cardiac CT-derived right ventricular ejection fraction (RVEF) in LTx candidates.

Methods: This retrospective study included patients who were listed for LTx and underwent cardiac computed tomography (CT) between September 2019 and December 2023.

gen. nov., sp. nov., a marine bacterium of the family isolated from a halophyte .

Two Gram-stain-negative, facultative anaerobic, rod-shaped and non-gliding bacteria, designated as HL-DH10 and HL-DH14, were isolated from the halophyte in a mudflat, Republic of Korea. Based on the results of 16S rRNA gene pairwise analysis, the two isolates were the members of the family , and SC17 was the most closely related to strains HL-DH10 and HL-DH14 with 96.3% and 95.

Use of acupuncture among chronic disease patients attending primary healthcare facilities: a cross-sectional study in Korea.

Background: Given the crucial role of integrating acupuncture treatment into primary care for managing chronic diseases, this study endeavors to identify the utilization of acupuncture among chronic disease patients seeking primary care services in Korea. Additionally, it aims to evaluate their knowledge level and perceptions related to acupuncture use.

Methods: A descriptive cross-sectional study was conducted among chronic disease patients attending a primary care clinic in Korea.

and Its Compounds as Complementary Therapy for Dyslipidemia: A Meta-Analysis of Clinical Efficacy and In Silico Mechanistic Insights.

Dyslipidemia is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), a leading cause of death worldwide. Burge is widely used in East Asia for cardiovascular health, showing potential benefits in lowering cholesterol and reducing inflammation. This study systematically reviewed and conducted a meta-analysis of randomized controlled trials (RCTs) to assess the clinical effectiveness of in treating dyslipidemia.

Identifying Herbal Candidates and Active Compounds for Psoriasis Through Multiscale Network Analysis.

Psoriasis is a chronic inflammatory skin disorder characterized by the hyperproliferation of keratinocytes and immune system dysregulation, with significant needs due to the limitations and adverse effects of current treatments. In this study, we sought to discover novel herbal candidates and their active compounds for psoriasis by leveraging a multiscale network analysis. We conducted a comprehensive analysis of data from 348 medicinal herbs and their active compounds, identifying , , , and as top candidates without reported evidence.

Culture-negative sepsis may be a different entity from culture-positive sepsis: a prospective nationwide multicenter cohort study.

Background: The distinction between culture-positive sepsis and culture-negative sepsis regarding clinical characteristics and outcomes remains contentious. We aimed to elucidate these differences using large-scale nationwide data.

Methods: This prospective cohort study analyzed data from the Korean Sepsis Alliance registry, comprising 21 intensive care units (ICUs) across 20 hospitals from September 2019 to December 2021.