Two-year prognosis of primary stabbing headache and its associated factors: a clinic-based study.

Background: Primary stabbing headache (PSH) is commonly seen in headache clinics, yet its long-term course remains inadequately explored. This study aimed to determine the 2-year recurrence rate of PSH and to identify associated risk factors.

Methods: Out of 1,756 patients who visited a specialized headache clinic due to headache complaints, 106 patients diagnosed with PSH were enrolled consecutively.

Early nimodipine treatment in reversible cerebral vasoconstriction syndrome: A serial transcranial Doppler study.

Objectives/background: Although nimodipine is commonly used to treat reversible cerebral vasoconstriction syndrome (RCVS), its disease-modifying effects are not yet understood. We prospectively investigated the effect of nimodipine and treatment initiation timing on the prevention of worsened vasoconstriction in patients with angiogram-proven RCVS.

Methods: In this prospective cohort study, we recruited patients with angiogram-proven RCVS who visited a single headache clinic between June 2019 and November 2021.

Cortical Thickness Changes in Migraine Patients Treated with Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies: A Prospective Age- and Sex-Matched Controlled Study.

Migraine is associated with structural brain abnormalities, including cortical thickness changes. Anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) are a novel therapy for migraine prevention, but their effects on cortical structures are poorly understood. In this prospective age- and sex-matched controlled study, 30 migraine patients receiving either anti-CGRP mAbs (fremanezumab) ( = 15) or oral preventive medications ( = 15) underwent 3T MRI scans before and after treatment.

Pain Lateralization in Cluster Headache and Associated Clinical Factors.

Background And Purpose: The pain lateralization in cluster headache (CH) may be related to the asymmetry in the functions of the brain hemispheres. The right-sided dominance of pain in CH has been found inconsistently across studies, and so we aimed to characterize this and identify the factors influencing pain lateralization during current and previous bouts.

Methods: This study enrolled 227 patients from the Korean Cluster Headache Registry between October 2018 and December 2020.

Meat yield and quality characteristics of Woori heukdon pigs as affected by dietary amino acids and chromium supplementation.

This study aimed to assess the effect of combined dietary supplementation with amino acids and chromium on carcass traits, meat yield and quality properties of finishing Woori heukdon (WHD) pigs. For this purpose, forty same-age WHD piglets were equally assigned into control and experimental groups (n = 20 per group). The control group were received a basal diet while, the experimental group were received a basal diet supplemented with additional 4% lysine, isoleucine, methionine, threonine, valine and tryptophan during growing phase (30-65 kg body weight), and a basal diet supplemented with 0.

Insights into glucose-derived carbon dot synthesis via Maillard reaction: from reaction mechanism to biomedical applications.

Carbon dots (CDs) are versatile nanomaterials that are considered ideal for application in bioimaging, drug delivery, sensing, and optoelectronics owing to their excellent photoluminescence, biocompatibility, and chemical stability features. Nitrogen doping enhances the fluorescence of CDs, alters their electronic properties, and improves their functional versatility. N-doped CDs can be synthesized via solvothermal treatment of carbon sources with nitrogen-rich precursors; however, systematic investigations of their synthesis mechanisms have been rarely reported.

Vehicle Localization Using Crowdsourced Data Collected on Urban Roads.

Vehicle localization using mounted sensors is an essential technology for various applications, including autonomous vehicles and road mapping. Achieving high positioning accuracy through the fusion of low-cost sensors is a topic of considerable interest. Recently, applications based on crowdsourced data from a large number of vehicles have received significant attention.

Comparison of Muscle Fiber and Meat Quality Characteristics of Beef Strip Loin, Tenderloin, and Round Cuts among Jeju Black Cattle, Hanwoo, and Their Crossbreeds.

This study assessed and compared meat quality and fiber characteristics of (LL), (PM), and muscles among Hanwoo (HW), Jeju black (BL), and their crossbred (BH) cattle. Twelve carcasses from each breed (36 in total) were used in this study. BL and BH had higher moisture and crude ash contents and lower crude fat and protein contents than HW, regardless of the muscle type.

Evaluation of the quality characteristics of nitrogen gas-stunned chicken meat and small intestine.

This study aimed to confirm the applicability of the new nitrogen (N) gas stunning method in the broiler slaughtering process by comparing the meat and small intestine quality following different stunning methods (electrical, carbon dioxide (CO), N, and halal). Four treatments were compared: (i) electrical stunning (Elec), (ii) 80% CO gas stunning (CO-gas), (iii) 98% N gas stunning (N-gas), and (iv) the non-stunning method (halal). N gas stunning (98%) and the halal method were conducted at the pilot plant abattoir of the national institute of animal science, Korea, and electrical and 80% CO stunning were performed on the nearest commercial slaughter house.

Quality Properties and Flavor-Related Components of Beef Muscle from Four Korean Native Cattle Breeds.

This study was carried out to assess the quality properties, components associated with taste and aroma of beef as a function of breed. For this purpose, steers from four Korean native cattle breeds: Hanwoo (n=10), Chikso (n=10), black Hanwoo (n=12, BHW) and Jeju black cattle (n=12, JBC) were used. The steers all were raised under identical conditions and finished at a similar age of around 30-months old.

Long-Term Outcome After Discontinuation of CGRP-Targeting Therapy for Migraine.

Purpose Of Review: Calcitonin gene-related peptide (CGRP)-targeting agents are potential candidates for disease-modifying migraine drugs. However, most studies on CGRP-targeting agents have assessed efficacy outcomes rather than long-term effects after discontinuation. This review aimed to synthesize and scrutinize the latest clinical data on the outcomes after the discontinuation of CGRP-targeting therapy in patients with episodic and chronic migraine, with a particular focus on chronic migraine.

Ameliorative Effect of Ginsenoside Rg6 in Periodontal Tissue Inflammation and Recovering Damaged Alveolar Bone.

Periodontal disease is a chronic disease with a high prevalence, and in order to secure natural materials to prevent oral diseases, new materials that protect periodontal tissue from inflammation are being sought. Genes were identified using real-time quantitative polymerase chain reaction (RT-qPCR), and proteins were confirmed using Western blot. Dichlorodihydrofluorescein diacetate (DCF-DA) analysis was used, and the antibacterial effects were confirmed through Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) analysis.

Efficacy of Oxygen Treatment Using Home Oxygen Concentrators for the Treatment of Cluster Headaches: A Randomized, Crossover, Multicenter Study.

Background And Purpose: Oxygen treatment is the first-line acute treatment for cluster headaches (CHs), but this can be impeded by insurance coverage and oxygen-tank maintenance. Oxygen concentrators filter nitrogen from ambient air to produce oxygen-rich gas, and can therefore be an alternative to conventional oxygen therapy using a tank. We investigated the effectiveness and safety of using two home oxygen concentrators and compared them with using oral zolmitriptan for the acute treatment of CHs.

Effects of mid-to-late prepartum feed supplementation in Hanwoo beef cows on their performance, blood metabolites, and the carcass characteristics and metabolites of their neonatal calves.

Introduction: This study aimed to evaluate the implications of supplementary nutrition during the mid-to-late pregnancy on various parameters in Hanwoo cows and their subsequent neonatal calves.

Materials And Methods: Eight Hanwoo cows in their first parity were divided into two groups. The control group (C, 100%) received 3kg of concentrate and 5kg of rice straw throughout the pregnancy period, while the treatment group (T, 150%) increased their diet during mid-to-late pregnancy.

Comparing counseling outcome for college students: Metaverse and in-person approaches.

This study compared metaverse counseling with in-person counseling, using in-person counseling as a comparison group. To achieve this, we assessed whether metaverse counseling, a novel treatment approach, is comparable to traditional in-person counseling. A total of 60 participants voluntarily participated in the study.

Rabbit Meat Extract Induces Browning in 3T3-L1 Adipocytes via the AMP-Activated Protein Kinase Pathway.

The browning of white adipocytes may be an innovative approach to address obesity. This study investigated the effects of rabbit meat extract on 3T3-L1 adipocytes, with a specific emphasis on inducing browning. The browning effects of rabbit meat extract were evaluated by analyzing genes specifically expressed in 3T3-L1 adipocytes using quantitative PCR and immunoblotting.

Predictable incorporation of nitrogen into carbon dots: insights from pinacol rearrangement and iminium ion cyclization.

Nitrogen-doped carbon dots (CDs) have attracted considerable attention across various research areas and applications due to their enhanced optical properties and photostability. However, the mechanism of nitrogen incorporation in CDs remains elusive, hampering the precise control over nitrogen-incorporated structures and the investigation of the effects of nitrogen on the electronic structure and optical properties of CDs. In this study, we employed a rational design approach, utilizing glucosamine and ethylene glycol as the carbon source and co-reagent, respectively, to synthesize N-doped CDs.

Update of Gepants in the Treatment of Chronic Migraine.

Purpose Of Review: Despite the unmet therapeutic needs of patients with chronic migraine (CM) and/or medication overuse, available treatment options are limited. Recently, four calcitonin gene-related peptide receptor antagonists, known as gepants, have been approved for the treatment of migraine. This review focuses on the preventive treatment of CM with gepants and highlights recent findings.

Flat bands, non-trivial band topology and rotation symmetry breaking in layered kagome-lattice RbTiBi.

A representative class of kagome materials, AVSb (A = K, Rb, Cs), hosts several unconventional phases such as superconductivity, [Formula: see text] non-trivial topological states, and electronic nematic states. These can often coexist with intertwined charge-density wave states. Recently, the discovery of the isostructural titanium-based single-crystals, ATiBi (A = K, Rb, Cs), which exhibit similar multiple exotic states but without the concomitant charge-density wave, has opened an opportunity to disentangle these complex states in kagome lattices.