Dual-Ionic Weakly Solvating Electrolyte Design Enables Efficient Fast-Cycling of High-Voltage Anion Shuttle Batteries.

Electrolytes shape solvation structures that govern ionic transport, stability, and interfacial properties in energy storage systems. Sodium-based dual-ion shuttling systems offer high-voltage and fast-charging potential but face challenges such as solvent co-intercalation, electrolyte decomposition, and low Coulombic efficiency, partly due to limited anion-focused electrolyte design. Herein, a low-concentration dual-ionic weakly solvating electrolyte (DWSE) is introduced, leveraging functionalized nano-graphene oxide additives to modulate the solvation environments of Na and PF .

Changes of urinary bisphenol A and alternatives in Korea 2015-2020 and environmental disparities by socioeconomic status.

Background: Bisphenol A (BPA), mainly used as an ingredient for epoxy resins, is widely utilized in numerous daily necessities. However, due to its endocrine-disrupting property, many countries have regulated BPA usage in consumer products, which might motivate industries to prefer alternative chemicals such as bisphenol S (BPS) and bisphenol F (BPF). This study aimed to evaluate temporal changes in consumption patterns of bisphenol-containing products and evaluate whether such trend depended on socioeconomic status (SES).

Outcomes of Patients With Embolic Stroke of Undetermined Source Treated With Antiplatelet Agents or Anticoagulation: A Multicenter Cohort Study.

Background And Objectives: Embolic stroke of undetermined source (ESUS) can be attributed to a variety of potential embolic sources, with differential response to anticoagulation.

Methods: A multicenter, retrospective observational cohort study (27 sites) of consecutive adult patients with acute ischemic stroke due to ESUS (admitted 2015-2024) was conducted. The aim was to compare outcomes after antiplatelet(s) vs anticoagulant (±antiplatelet) treatment in patients with ESUS across potential embolic sources.

Electrolyte solution chemistry and interface dynamics for fast-charging sustainable anion shuttle batteries.

The demand for sustainable and fast-charging energy storage systems has grown significantly, yet traditional lithium-ion batteries (LIBs) face challenges related to costly resources and sluggish charge transport kinetics. As a promising alternative, dual-ion batteries (DIBs), also known as anion-shuttle batteries, have gained attention for their high operational voltage and ultrafast charging capabilities. Unlike conventional rocking-chair batteries, DIBs utilize both cations and anions as charge carriers, reducing rate-limiting steps and eliminating long-range ion migration.

XPC-RAD23B enhances UV-DDB binding to DNA to facilitate lesion search in nucleotide excision repair.

Ultraviolet-induced DNA lesions are removed by the nucleotide excision repair (NER) pathway. In global-genome NER (GG-NER), XPC-RAD23B recognizes the lesions and initiates NER. However, cyclobutane pyrimidine dimers (CPDs), which do not significantly destabilize the DNA duplex, are not bound by XPC-RAD23B with high selectivity.

Mapping protein-metabolite interactions in . by integrating chromatographic techniques and co-fractionation mass spectrometry.

Toward characterization of protein-metabolite interactomes, we recently introduced PROMIS, a co-fractionation-based mass spectrometry approach. However, the challenge lies in distinguishing true interactors from coincidental co-elution when a metabolite co-fractionates with numerous proteins. To address this, we integrated two chromatographic techniques-size exclusion and ion exchange-to enhance the mapping of protein-metabolite interactions (PMIs) in .

The Role of EMP2 in Triple-negative Breast Cancer.

Background/aim: The poor prognosis of triple-negative breast cancer (TNBC) is largely due to the lack of targeted therapies, as a result of the absence of estrogen, progesterone, and HER2 receptors. Our previous studies highlighted Del-1 as a potential therapeutic target and biomarker for TNBC. This study further explores molecules regulated by Del-1 through transcriptomic analysis.

Unbalanced Associations between Physical, Psychological, and Social Domains of the Leicester Cough Questionnaire: Network and Mediation Analyses.

Background: The Leicester Cough Questionnaire (LCQ) is a validated instrument for evaluating cough-related impairments within three domains: physical, psychological, and social. This study investigated how the physical, psychological, and social domains of chronic cough are interrelated using the LCQ.

Methods: Adult patients with chronic cough from 16 respiratory centers who completed the LCQ and underwent diagnostic workup were retrospectively reviewed.

DNA repair and disease: insights from the human DNA glycosylase NEIL family.

The base excision repair pathway protects DNA from base damage via oxidation, deamination, alkylation and methylation. DNA glycosylases are key enzymes that recognize damaged bases in a lesion-specific manner and initiate the base excision repair process. Among these, the endonuclease VIII-like 1-3 (NEIL1-3) family, which is found in mammalian genomes, is a homolog of bacterial DNA glycosylases known as Fpg/Nei.

Identification of Endometriosis Pathophysiologic-Related Genes Based on Meta-Analysis and Bayesian Approach.

Endometriosis is a complex disease with diverse etiologies, including hormonal, immunological, and environmental factors; however, its exact pathogenesis remains unknown. While surgical approaches are the diagnostic and therapeutic gold standard, identifying endometriosis-associated genes is a crucial first step. Five endometriosis-related gene expression studies were selected from the available datasets.

Toward Long-Life High-Voltage Aqueous Li-Ion Batteries: from Solvation Chemistry to Solid-Electrolyte-Interphase Layer Optimization Against Electron Tunneling Effect.

Water is pursued as an electrolyte solvent for its non-flammable nature compared to traditional organic solvents, yet its narrow electrochemical stability window (ESW) limits its performance. Solvation chemistry design is widely adopted as the key to suppress the reactivity of water, thereby expanding the ESW. In this study, an acetamide-based ternary eutectic electrolyte achieved an ESW ranging from 1.

Prevalence of high-risk group for obstructive sleep apnea using the STOP-Bang questionnaire and its association with cardiovascular morbidity.

Objectives: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder, yet many cases remain undiagnosed. The STOP-Bang questionnaire was developed to identify individuals at high risk of OSA. We aimed to investigate the prevalence of individuals with suspected OSA using the STOP-Bang risk stratification in the general population of South Korea.

Relationship between client laughter and session outcomes in metaverse counseling.

Considering the growing interest in VR psychotherapy, this study investigated the relationship between client laughter and session outcomes in metaverse counseling. To investigate the relationships between types of client laughter and session outcomes in metaverse counseling, we employed a multilevel analysis by separating the variables into two levels: session-level (between-sessions) and client-level (between-clients). The dataset included 159 sessions nested among 26 clients.

Magnetically-Controlled Graphite Alignment for Fast and Stable Anion Intercalation.

Dual-ion batteries (DIBs) are emerging as promising candidates for fast-charging electric vehicles owing to their ability to intercalate both cations and anions. However, increasing the energy density of DIBs, especially with thick graphite cathodes, remains a challenge due to structural instability during anion intercalation. In this study, a magnetically controlled method is introduced to vertically align graphite particles in thick electrodes, significantly improving the performance of DIBs.

β-PIX-d, a Member of the ARHGEF7 Guanine Nucleotide Exchange Factor Family, Activates Rac1 and Induces Neuritogenesis in Primary Cortical Neurons.

β-PIX, a Rac1/Cdc42-specific guanine nucleotide exchange factor, is known to regulate actin cytoskeleton remodeling during cell migration. In this study, we investigated the effects of β-PIX-d, an isoform of β-PIX, on neocortical development and neuritogenesis. Overexpression of β-PIX-d in the embryonic neocortex induced increased cell clusters and enhanced neurite outgrowth in cortical neurons.

Long non-coding RNA SOX2OT in tamoxifen-resistant breast cancer.

Hormone receptor (HR)-positive breast cancer can become aggressive after developing hormone-treatment resistance. This study elucidated the role of long non-coding RNA (lncRNA) SOX2OT in tamoxifen-resistant (TAMR) breast cancer and its potential interplay with the tumor microenvironment (TME). TAMR breast cancer cell lines TAMR-V and TAMR-H were compared with the luminal type A cell line (MCF-7).

Development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinine.

Increased body fluids during pregnancy complicates the application of estimated glomerular filtration rate (eGFR) formulas that are based on body surface area. Furthermore, gestational renal dysfunction cannot be identified if the serum creatinine (SCr) concentration is within the non-pregnant reference interval (RI) despite inadequate pregnancy-related renal hyperfiltration. 1484 SCr measurements from 957 healthy pregnant women were collected.