Patient, Family and Provider Priorities in ICU Rehabilitation: An Experience-Based Co-Design Study.

Background: Intensive care unit (ICU) rehabilitation has been shown to improve physical, psychological and functional outcomes in critically ill patients. However, implementation varies widely, and clinical practice guidelines (CPGs) are needed to ensure consistent, evidence-based care. Incorporating patient and public involvement (PPI) into CPG development is essential to reflect the lived experiences and priorities of service users.

ANALGESIC EFFECTS OF PREEMPTIVE CELECOXIB OR TRAMADOL/ACETAMINOPHEN ADDED TO STANDARD POSTOPERATIVE PAIN MANAGEMENT IN IMPACTED MANDIBULAR THIRD MOLAR EXTRACTION: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL.

Objectives: This study aimed to assess the efficacy and safety of adding single-dose preemptive celecoxib 200 mg (Cc) or tramadol 37.5 mg/acetaminophen 325.0 mg (T/A) to standard postoperative analgesia after impacted mandibular third molar extraction, a design not previously explored.

An Assessment of the Maturity of Cancer Survival Data Used in Economic Models for the National Institute for Health and Care Excellence's Single Technology Appraisals.

Objectives: This study examines the maturity of survival data used in cancer drug appraisals by the National Institute for Health and Care Excellence (NICE) and the implications for decision making.

Methods: We assessed the maturity of survival data used in economic models within NICE single technology appraisals published between January 1, 2011 and December 31, 2023 (n = 301). We categorized these survival data according to whether they were "highly immature" (<20% of events), "immature" (20%-50%), or "mature" (>50%).

Cutoff Values for Screening Post-Intensive Care Syndrome Using the Post-Intensive Care Syndrome Questionnaire.

: Post-intensive care syndrome (PICS) affects over half of intensive care unit (ICU) survivors, impairing their long-term health and quality of life. Although the Post-Intensive Care Syndrome Questionnaire (PICSQ) was developed to measure PICS, validated cutoff values for screening are lacking. This study aimed to determine optimal cutoff values for each domain of the PICSQ.

Unbalanced Associations between Physical, Psychological, and Social Domains of the Leicester Cough Questionnaire: Network and Mediation Analyses.

Background: The Leicester Cough Questionnaire (LCQ) is a validated instrument for evaluating cough-related impairments within three domains: physical, psychological, and social. This study investigated how the physical, psychological, and social domains of chronic cough are interrelated using the LCQ.

Methods: Adult patients with chronic cough from 16 respiratory centers who completed the LCQ and underwent diagnostic workup were retrospectively reviewed.

Association Between Person-centered Care, Intensive Care Experience, and Post-intensive Care Syndrome in Critical Care Survivors: A Multi-center Prospective Cohort Study.

Purpose: This study aimed to investigate the association between patient-centered care, experiences in the intensive care unit (ICU), and post-intensive care syndrome among critical care survivors.

Methods: This was a prospective, multicenter cohort study conducted in the second year, focusing on post-intensive care syndrome among ICU survivors. This study was conducted in 19 ICUs at four university hospitals located in Busan, South Korea.

Effects of Virtual Reality Meditation on Sleep and Delirium in ICU Patients: A Randomized Controlled Trial.

The purpose of this study was to evaluate the effectiveness of virtual reality meditation compared with standard care on sleep quality and delirium incidence in patients admitted to the ICU. We conducted a randomized controlled trial with 96 patients in an 11-bed surgical ICU at a South Korean university hospital. The control group received usual sleep care, whereas the intervention group received an additional 20-minute virtual reality-based mindfulness and relaxation meditation before bedtime.

Lysosome-Targeting Chimera Using Mannose-6-Phosphate Glycans Derived from Glyco-Engineered Yeast.

Lysosome-targeting chimeras (LYTACs) harness the cell's lysosomal degradation machinery to break down extracellular and membrane proteins. Previous methods used a synthetic glycopeptide containing multiple serine-O-mannose-6-phosphate (poly-M6Pn), which presented challenges such as synthetic complexity and potential immunogenicity associated with poly-M6Pn. This study introduced a LYTAC formulation, LYTAC, which uses glyco-engineered yeast-derived mannose-6-phosphate glycans (gyM6pGs) for lysosomal transport, overcoming synthetic complexities and immunogenic risks.

Characterization of Mutants Generated by Long-Term Serial Treatment with a Low Concentration of Ethyl Methanesulfonate.

is a microalga that has great promise for the production of biofuels, functional foods, and bioactive compounds, and mutagenesis and effective screening methods are required to develop strains that have industrial use. Ethyl methanesulfonate (EMS) is a widely used mutagen, but is highly lethal to at typical concentrations. In the present study, low-concentration, long-time EMS exposure combined with serial treatment was introduced for generating mutants.

Efficacy of opioid combination versus single opioid for adult cancer pain: a protocol for systematic review and meta-analysis.

Introduction: Chronic pain is one of the most common and serious symptoms of cancer. Despite the limitations of dose titration using only one type of opioid, the effects of opioid combinations are poorly understood.

Methods And Analysis: This study will be conducted in accordance with the Cochrane Handbook of Systematic Reviews of Interventions 6.

Prevalence of high-risk group for obstructive sleep apnea using the STOP-Bang questionnaire and its association with cardiovascular morbidity.

Objectives: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder, yet many cases remain undiagnosed. The STOP-Bang questionnaire was developed to identify individuals at high risk of OSA. We aimed to investigate the prevalence of individuals with suspected OSA using the STOP-Bang risk stratification in the general population of South Korea.

Survival Is Just the Beginning of Recovery: A Qualitative Study of Survivors' Experiences after Severe Injury.

Purpose: Patients experience severe physical trauma every year. However, studies on survivors' experiences after severe injury are limited. Previous studies have mainly focused on time spans of trauma treatment.

Longitudinal trajectories of health-related quality of life among critical care survivors: A latent class growth approach.

Objectives: This study explored the trajectories of health-related quality of life (HRQOL) and the factors influencing these trajectories.

Research Methodology/design: Prospective observational cohort study.

Setting: 19 intensive care units (ICUs) in South Korea.

Analysis of factors associated with use of real-world data in single technology appraisals of cancer drugs by the National Institute for Health and Care Excellence.

Objectives: This study investigates factors associated with use of real-world data (RWD) in economic modelling for single technology appraisals (STAs) of cancer drugs by the National Institute for Health and Care Excellence (NICE) to improve systematic understanding of the use of RWD.

Methods: The data were extracted from STAs of cancer drugs, for which NICE issued guidance between January 2011 and December 2022 (n=267). Binary regression was used to test hypotheses concerning the greater or lesser use of RWD.

Sex-related disparities in cough-associated symptoms across different age groups.

Background: Sex-related disparities in the prevalence of chronic cough have been consistently reported globally, with varying male-to-female ratios.

Objectives: This study aimed to evaluate sex-related differences by comparing correlations between cough-related symptoms in males and females of different age groups.

Design: Adult patients with chronic cough who completed the Leicester Cough Questionnaire (LCQ) were recruited from 16 respiratory centers.

Resist-as-Needed ADL Training With SPINDLE for Patients With Tremor.

Individuals with neurological disorders often exhibit altered manual dexterity and muscle weakness in their upper limbs. These motor impairments with tremor lead to severe difficulties in performing Activities of Daily Living (ADL). There is a critical need for ADL-focused robotic training that improves individual's strength when engaging with dexterous ADL tasks.

Cross-sectional analysis of use of real-world data in single technology appraisals of oncological medicine by the National Institute for Health and Care Excellence in 2011-2021.

Objectives: This study aims to identify how real-world data (RWD) have been used in single technology appraisals (STAs) of cancer drugs by the National Institute for Health and Care Excellence (NICE).

Design: Cross-sectional study of NICE technology appraisals of cancer drugs for which guidance was issued between January 2011 and December 2021 (n=229). The appraisals were reviewed following a published protocol to extract the data about the use of RWD.

Video-assisted thoracic surgery for an endobronchial ancient schwannoma obstructing the left main bronchus.

A schwannoma is a tumor that arises from the Schwann cells of the peripheral nerves. Primary pulmonary schwannomas are extremely rare, although they can occur anywhere in the body. Symptoms of endobronchial schwannoma vary depending upon the extent of bronchi blockage by the tumor.

Estimating the prevalence and clinical significance of chronic obstructive pulmonary disease-obstructive sleep apnea overlap in South Korea.

Introduction: Concurrent obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are referred to as COPD-OSA overlap. We investigated the prevalence and clinical significance of COPD-OSA overlap in the general population of South Korea.

Methods: Data were obtained from the 2019 Korea National Health and Nutrition Examination Survey.

Incidence rate and risk factors for post-intensive care syndrome subtypes among critical care survivors three months after discharge: A prospective cohort study.

Objectives: To investigate the incidence of post-intensive care syndrome subtypes and their risk factors among intensive care unit survivors.

Research Methodology/design: This prospective observational cohort study assessed post-intensive care syndrome at three months after discharge in 475 survivors (median age of 62 years, 59.4 % male) admitted for more than 24 hours to 19 intensive care units.