Redox-responsive core-cross-linked micelles of miktoarm maltoheptaose-b-poly(furfuryl methacrylate) for enhanced anticancer drug delivery.

The instability of nanocarriers and premature leakage of drugs during circulation in the body remain major challenges that frequently lead to undesirable side effects in the development of nanomedicines. Achieving effective drug release within the tumor microenvironment is a key goal for desirable chemotherapy. In this study, we designed a novel type of core-cross-linked micelles (CCL) formed from biocompatible oligosaccharide-based AB miktoarm block copolymers of (maltoheptaose)-b-poly(furfuryl methacrylate) ((MH)-b-PFMA).

Self-Signal-Triggered Drug Delivery System for Tumor Therapy Using Cancer Cell Membrane-Coated Biocompatible MnO Nanocomposites.

In anti-cancer metastasis treatment, precise drug delivery to cancer cells remains a challenge. Innovative nanocomposites are developed to tackle these issues effectively. The approach involves the creation of manganese oxide (MnO) nanoparticles (NPs) and their functionalization using trisodium citrate to yield functionalized MnO NPs (F-MnO NPs), with enhanced water solubility, stability, and biocompatibility.

Reduction-Responsive Chitosan-Based Injectable Hydrogels for Enhanced Anticancer Therapy.

Selective delivery of anticancer drug molecules to the tumor site enhances local drug dosages, which leads to the death of cancer cells while simultaneously minimizing the negative effects of chemotherapy on other tissues, thereby improving the patient's quality of life. To address this need, we developed reduction-responsive chitosan-based injectable hydrogels via the inverse electron demand Diels-Alder reaction between tetrazine groups of disulfide-based cross-linkers and norbornene groups of chitosan derivatives, which were applied to the controlled delivery of doxorubicin (DOX). The swelling ratio, gelation time (90-500 s), mechanical strength (G'~350-850 Pa), network morphology, and drug-loading efficiency (≥92%) of developed hydrogels were investigated.

Redox-Responsive Comparison of Diselenide and Disulfide Core-Cross-Linked Micelles for Drug Delivery Application.

In this study, diselenide (Se-Se) and disulfide (S-S) redox-responsive core-cross-linked (CCL) micelles were synthesized using poly(ethylene oxide)--poly(furfuryl methacrylate) (PEO--PFMA), and their redox sensitivity was compared. A single electron transfer-living radical polymerization technique was used to prepare PEO--PFMA from FMA monomers and PEO-Br initiators. An anti-cancer drug, doxorubicin (DOX), was incorporated into PFMA hydrophobic parts of the polymeric micelles, which were then cross-linked with maleimide cross-linkers, 1,6-bis(maleimide) hexane, dithiobis(maleimido) ethane and diselenobis(maleimido) ethane via Diels-Alder reaction.

Redox-Responsive Core-Cross-Linked Micelles of Miktoarm Poly(ethylene oxide)--poly(furfuryl methacrylate) for Anticancer Drug Delivery.

The physiological instability of nanocarriers, premature drug leakage during blood circulation, and associated severe side effects cause compromised therapeutic efficacy, which have significantly hampered the progress of nanomedicines. The cross-linking of nanocarriers while keeping the effectiveness of their degradation at the targeted site to release the drug has emerged as a potent strategy to overcome these flaws. Herein, we have designed novel (poly(ethylene oxide))--poly(furfuryl methacrylate) ((PEO)--PFMA) miktoarm amphiphilic block copolymers by coupling alkyne-functionalized PEO (PEO-C≡H) and diazide-functionalized poly(furfuryl methacrylate) ((N)-PFMA) via click chemistry.

Near-Infrared Light-Responsive Shell-Crosslinked Micelles of Poly(d,l-lactide)--poly((furfuryl methacrylate)--(-acryloylmorpholine)) Prepared by Diels-Alder Reaction for the Triggered Release of Doxorubicin.

In the present study, we developed near-infrared (NIR)-responsive shell-crosslinked (SCL) micelles using the Diels-Alder (DA) click reaction between an amphiphilic copolymer poly(d,l-lactide)--poly((furfuryl methacrylate)--(-acryloylmorpholine)) (PLA--P(FMA--NAM)) and a diselenide-containing crosslinker, bis(maleimidoethyl) 3,3'-diselanediyldipropionoate (BMEDSeDP). The PLA--P(FMA--NAM) copolymer was synthesized by RAFT polymerization of FMA and NAM using a PLA-macro-chain transfer agent (PLA-CTA). The DA reaction between BMEDSeDP and the furfuryl moieties in the copolymeric micelles in water resulted in the formation of SCL micelles.

Total Syntheses of Echitamine, Akuammiline, Rhazicine, and Pseudoakuammigine.

Echitamine (1) and akuammiline (2) are representative members of a fascinating class of monoterpenoid indole alkaloids. We report the syntheses of 2 and its congener deacetylakuammiline (3). The azabicyclo[3.