Advances in Transdermal Drug Delivery Systems and Clinical Applications in Inflammatory Skin Diseases.

Inflammatory skin diseases are highly prevalent conditions characterized by complex immune responses that result in skin tissue damage and pain, significantly impacting patients' physical health. Traditional therapeutic approaches, including oral administration and injections, continue to exhibit inherent limitations. Consequently, there is growing interest in exploring alternative drug delivery systems that offer more effective, targeted, and patient-friendly therapeutic options.

Whole heart perfusion with high-multiband Simultaneous Multislice Imaging via Linear phase modulated Extended field of view (SMILE).

Purpose: To develop a simultaneous multislice (SMS) first-pass perfusion technique that can achieve whole heart coverage with high multi-band factors, while avoiding the issue of slice leakage.

Methods: The proposed Simultaneous Multislice Imaging via Linear phase modulated Extended field of view (SMILE) treats the SMS acquisition and reconstruction within an extended field of view framework, allowing arbitrarily under-sampling of phase encoding lines of the extended k-space matrix and enabling the direct application of 2D parallel imaging reconstruction techniques. We presented a theoretical framework that offers insights into the performance of SMILE.

MRI recovery with self-calibrated denoisers without fully-sampled data.

Objective: Acquiring fully sampled training data is challenging for many MRI applications. We present a self-supervised image reconstruction method, termed ReSiDe, capable of recovering images solely from undersampled data.

Materials And Methods: ReSiDe is inspired by plug-and-play (PnP) methods, but unlike traditional PnP approaches that utilize pre-trained denoisers, ReSiDe iteratively trains the denoiser on the image or images that are being reconstructed.

Prokaryotic Expression and Functional Verification of Antimicrobial Peptide LR.

The antimicrobial peptide LR (LLRLLRRGGRRLLRLL-NH2) was designed and chemically synthesized in a study conducted by Jia et al. Gram-negative bacteria were found to be sensitive to LR and exhibited a high therapeutic index. Genetic engineering methods were used to create the prokaryotic fusion expression vector pQE-GFP-LR, and the resulting corresponding fusion protein GFP-LR was subsequently expressed and purified.

Establishment and validation of a nomogram to predict postoperative anemia after total hip arthroplasty.

Background: Anemia is a common complication of total hip arthroplasty (THA). In this study, we evaluated the preoperative risk factors for postoperative anemia after THA and developed a nomogram model based on related preoperative and intraoperative factors.

Methods: From January 2020 to May 2023, 927 THA patients at the same medical center were randomly assigned to either the training or validation cohort.

Early clinical efficacy analysis of enhanced recovery following surgery combined with interscalene brachial plexus block for arthroscopic rotator cuff repair.

To explore the early clinical value of enhanced recovery after surgery (ERAS) with interscalene brachial plexus block (ISB) for arthroscopic rotator cuff repair (ARCR). We enrolled 240 patients who underwent arthroscopic rotator cuff repair, randomly divided into 3 groups (n = 80 each). Groups A, B, and C underwent only surgery, surgery + ERAS, and ISB + surgery + ERAS, respectively.

MRI RECOVERY WITH A SELF-CALIBRATED DENOISER.

Plug-and-play (PnP) methods that employ application-specific denoisers have been proposed to solve inverse problems, including MRI reconstruction. However, training application-specific denoisers is not feasible for many applications due to the lack of training data. In this work, we propose a PnP-inspired recovery method that does not require data beyond the single, incomplete set of measurements.

FREE-BREATHING CARDIOVASCULAR MRI USING A PLUG-AND-PLAY METHOD WITH LEARNED DENOISER.

Cardiac magnetic resonance imaging (CMR) is a noninvasive imaging modality that provides a comprehensive evaluation of the cardiovascular system. The clinical utility of CMR is hampered by long acquisition times, however. In this work, we propose and validate a plug-and-play (PnP) method for CMR reconstruction from undersampled multicoil data.