H and P MRS Interleaved With High Time Resolution Reveals Closely Matching Creatine CH₂ and PCr Dynamics During Exercise.

The rate of intramuscular phosphocreatine (PCr) depletion and recovery in response to exercise estimated from P MRS is an established measure for oxidative capacity. The creatine CH resonance in H MRS is known to exhibit a similar pattern. So far, repeating the exercise for consecutive H and P experiments posed limitations on the interpretation.

Five-Year Clinical and MRI-Based Outcomes After Cartilage Repair With or Without ACL Reconstruction: Worse Clinical Outcome after ACL Reconstruction Does not Affect Cartilage Repair Tissue Quality.

ObjectivesCartilage repair (CR) surgery and anterior cruciate ligament reconstruction (ACL-R) are common joint procedures, particularly in younger patients. However, the impact of prior or concurrent ACL-R on the outcomes of CR remains uncertain. This study aimed to evaluate whether ACL-R affects the structural quality and clinical outcomes of CR tissue.

Magnetic resonance fingerprinting for the whole knee articular cartilage assessment using automated pipeline.

Objectives: To evaluate the feasibility of a prototype MRF sequence in an automated pipeline for T2 extraction of knee cartilage, and to compare it to the same procedure with a conventional T2 mapping sequence.

Materials And Methods: Seventeen healthy volunteers and twenty patients with a focal cartilage damage ICRS grade I-III diagnosed via morphological MRI underwent knee MRI examination, including a prototype MRF sequence, a conventional multi-slice multi-echo (MSME) T2 mapping sequence and double-echo steady-state sequence (DESS). Automated cartilage segmentation with a subsequent automated pipeline for T2 extraction from both T2 maps was performed.

Assessment of AI-accelerated T2-weighted brain MRI, based on clinical ratings and image quality evaluation.

Objective: To compare clinical ratings and signal-to-noise ratio (SNR) measures of a commercially available Deep Learning-based MRI reconstruction method (T2) against conventional T2- turbo spin echo brain MRI (T2).

Materials And Methods: 100 consecutive patients with various neurological conditions underwent both T2 and T2 on a Siemens Vida 3 T scanner with a 64-channel head coil in the same examination. Acquisition times were 3.

Long-Term Impact of Intralesional Bony Overgrowth on Opposing Cartilage Integrity: Five-Year Results Following Cartilage Repair.

ObjectivesThis study aimed to assess the impact of intralesional bony overgrowth (ILBO) after cartilage repair on the integrity of opposing articulating cartilage (OpAC) using T2 mapping and to correlate these findings with clinical outcomes.MethodsIn this multicenter study, magnetic resonance imaging (MRI) examinations were performed in the follow-up after cartilage repair (Microfracturing (MFX) and Matrix-Induced Autologous Chondrocyte Implantation (MACI)) in 45 patients up to 5 years after surgery. T2 values of the OpAC after 3, 12, and 60 months in patients with and without ILBO after 60 months were conducted along with clinical assessments (International Knee Documentation Committee (IKDC) and Knee injury and Osteoarthritis Outcome Score (KOOS)).

Gender-affirming hormone therapy and its impact on myocardial mass and cardiac function: a prospective magnetic resonance cohort study on transgender men and women.

Objective: Differences in cardiac parameters such as myocardial mass, left ventricular ejection fraction (LVEF), cardiac output, and brain natriuretic peptide (NT-proBNP) levels between cisgender men and women are well established. No evidence exists regarding changes in myocardial mass or cardiac function parameters in transgender individuals undergoing gender-affirming hormone therapy (GAHT).

Design, Setting, Participants, And Main Outcomes: A prospective study enrolling transgender individuals under GAHT (20 individuals assigned female at birth [AFAB] and 15 assigned male at birth [AMAB]) was conducted at the Medical University of Vienna from 2019 to 2022.

Texture Analysis of Cartilage Repair Tissue Maturation: Comparison of Two Cartilage Repair Methods and Correlation with MOCART 2.0.

Objective: The objective of this study was to assess the maturation of matrix-associated autologous chondrocyte transplantation (MACT) grafts up to 2 years after the surgery using gray-level co-occurrence matrix (GLCM) texture analysis of quantitative T maps, compare the results with the microfracturing technique (MFX) control group, and relate these results to the morphological MOCART 2.0 score.

Design: A subcohort of 37 patients from prospective, multi-center study underwent examination on a 3T MR scanner, including a T mapping sequence at 3, 12, and 24 months after surgery.

Topographical mapping of metabolic abnormalities in multiple sclerosis using rapid echo-less 3D-MR spectroscopic imaging at 7T.

Objectives: To assess topographical patterns of metabolic abnormalities in the cerebrum of multiple sclerosis (MS) patients and their relationship to clinical disability using rapid echo-less 3D-MR spectroscopic imaging (MRSI) at 7T.

Materials And Methods: This study included 26 MS patients (13 women; median age 34) and 13 age- and sex-matched healthy controls (7 women; median age 33). Metabolic maps were obtained using echo-less 3D-MRSI at 7T with a 64 × 64 × 33 matrix and a nominal voxel size of 3.

The effects of gender-affirming hormone therapy on myocardial, hepatic, pancreatic lipid content, body fat distribution and other cardiometabolic risk factors: A magnetic resonance-based study in transgender individuals.

Purpose: We aimed to assess the changes in body fat distribution, intraorgan lipid accumulation, and cardiometabolic risk factors after 6 months of gender-affirming hormone therapy (GAHT) in transgender men (TM) and transgender women (TW).

Methods: Conducted at the Medical University of Vienna between 2019 and 2022, the study included 15 TW and 20 TM. We conducted magnetic resonance imaging and spectroscopy to determine the visceral (VAT) and subcutaneous adipose tissue (SAT) amounts, the VAT/SAT ratio, and the intraorgan lipid content (liver, pancreas, myocardium), bloodwork, and an oral glucose tolerance test at baseline and after 6 months of GAHT.

Diagnostic accuracy of texture analysis applied to T- and T-Relaxation maps for liver fibrosis classification via machine-learning algorithms with liver histology as reference standard.

Objectives: To explore texture analysis' ability on T and T relaxation maps to classify liver fibrosis into no-to-mild liver fibrosis (nmF) versus severe fibrosis (sF) group using machine learning algorithms and histology as reference standard.

Materials And Methods: In this single-center study, patients undergoing 3 T MRI who also had histology examination were retrospectively enrolled. SNAPSHOT-FLASH sequence for T1 mapping, radial turbo-spin-echo sequence for T2 mapping and spin-echo echo-planar-imaging magnetic resonance elastography (MRE) sequences were analyzed.

Concentric Ring Trajectory Sampling With k-Space Reordering Enables Assessment of Tissue-Specific T and T Relaxation for H-Labeled Substrates in the Human Brain at 7 T.

Deuterium metabolic imaging (DMI) is an emerging Magnetic Resonance technique providing valuable insight into the dynamics of cellular glucose (Glc) metabolism of the human brain in vivo using deuterium-labeled (H) glucose as non-invasive tracer. Reliable concentration estimation of H-Glc and downstream synthesized neurotransmitters glutamate + glutamine (Glx) requires accurate knowledge of relaxation times, but so far tissue-specific T and T relaxation times (e.g.

Sex differences in ectopic lipid deposits and cardiac function across a wide range of glycemic control: a secondary analysis.

Objective: The objective of this study was to identify sex differences in ntrahepatocellular (HCL) and intramyocardial lipids (MYCL) and cardiac function in participants with different grades of glucometabolic impairment and different BMI strata.

Methods: Data from 503 individuals from 17 clinical experimental studies were analyzed. HCL and MYCL were assessed with 3T and 7T scanners by magnetic resonance spectroscopy.

Stimulus-induced rotary saturation imaging of visually evoked response: A pilot study.

Spin-lock (SL) pulses have been proposed to directly detect neuronal activity otherwise inaccessible through standard functional magnetic resonance imaging. However, the practical limits of this technique remain unexplored. Key challenges in SL-based detection include ultra-weak signal variations, sensitivity to magnetic field inhomogeneities, and potential contamination from blood oxygen level-dependent effects, all of which hinder the reliable isolation of neuronal signals.

The use of 7T MRI in multiple sclerosis: review and consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.

The use of ultra-high-field 7-Tesla (7T) MRI in multiple sclerosis (MS) research has grown significantly over the past two decades. With recent regulatory approvals of 7T scanners for clinical use in 2017 and 2020, the use of this technology for routine care is poised to continue to increase in the coming years. In this context, the North American Imaging in MS Cooperative (NAIMS) convened a workshop in February 2023 to review the previous and current use of 7T technology for MS research and potential future research and clinical applications.

Bone marrow edema-like signal after cartilage repair does not affect outcomes in a five-year follow-up.

Objectives: Bone marrow edema-like signal (BMELS) after cartilage repair is common, but its clinical significance remains uncertain. This study aimed to investigate the clinical and structural significance of BMELS following microfracturing (MFX) and matrix-induced autologous chondrocyte implantation (MACI).

Methods: In this multicenter study, MRI examinations were performed over a period of 5 years after cartilage repair surgery (MFX n = 17; MACI n = 28) in 45 patients.

The MOCART (magnetic resonance observation of cartilage repair tissue) 2.0 Ankle Score.

Objectives: The aim of this study was to introduce the MOCART 2.0 ankle score and evaluate its utility and reproducibility for the radiological assessment of cartilage repair tissue in the ankle joint.

Methods: The MOCART 2.

7 Tesla magnetic resonance spectroscopic imaging predicting IDH status and glioma grading.

Introduction: With the application of high-resolution 3D 7 Tesla Magnetic Resonance Spectroscopy Imaging (MRSI) in high-grade gliomas, we previously identified intratumoral metabolic heterogeneities. In this study, we evaluated the potential of 3D 7 T-MRSI for the preoperative noninvasive classification of glioma grade and isocitrate dehydrogenase (IDH) status. We demonstrated that IDH mutation and glioma grade are detectable by ultra-high field (UHF) MRI.

A modular motion compensation pipeline for prospective respiratory motion correction of multi-nuclear MR spectroscopy.

Magnetic resonance (MR) acquisitions of the torso are frequently affected by respiratory motion with detrimental effects on signal quality. The motion of organs inside the body is typically decoupled from surface motion and is best captured using rapid MR imaging (MRI). We propose a pipeline for prospective motion correction of the target organ using MR image navigators providing absolute motion estimates in millimeters.

Whole-brain deuterium metabolic imaging via concentric ring trajectory readout enables assessment of regional variations in neuronal glucose metabolism.

Deuterium metabolic imaging (DMI) is an emerging magnetic resonance technique, for non-invasive mapping of human brain glucose metabolism following oral or intravenous administration of deuterium-labeled glucose. Regional differences in glucose metabolism can be observed in various brain pathologies, such as Alzheimer's disease, cancer, epilepsy or schizophrenia, but the achievable spatial resolution of conventional phase-encoded DMI methods is limited due to prolonged acquisition times rendering submilliliter isotropic spatial resolution for dynamic whole brain DMI not feasible. The purpose of this study was to implement non-Cartesian spatial-spectral sampling schemes for whole-brain H FID-MR Spectroscopic Imaging to assess time-resolved metabolic maps with sufficient spatial resolution to reliably detect metabolic differences between healthy gray and white matter regions.

A Comparison of 7 Tesla MR Spectroscopic Imaging and 3 Tesla MR Fingerprinting for Tumor Localization in Glioma Patients.

This paper investigated the correlation between magnetic resonance spectroscopic imaging (MRSI) and magnetic resonance fingerprinting (MRF) in glioma patients by comparing neuro-oncological markers obtained from MRSI to T1/T2 maps from MRF. Data from 12 consenting patients with gliomas were analyzed by defining hotspots for T1, T2, and various metabolic ratios, and comparing them using Sørensen-Dice similarity coefficients (DSCs) and the distances between their centers of intensity (COIDs). The median DSCs between MRF and the tumor segmentation were 0.

Correlation between skeletal muscle acetylcarnitine and phosphocreatine metabolism during submaximal exercise and recovery: interleaved H/P MRS 7 T study.

Acetylcarnitine is an essential metabolite for maintaining metabolic flexibility and glucose homeostasis. The in vivo behavior of muscle acetylcarnitine content during exercise has not been shown with magnetic resonance spectroscopy. Therefore, this study aimed to explore the behavior of skeletal muscle acetylcarnitine during rest, plantar flexion exercise, and recovery in the human gastrocnemius muscle under aerobic conditions.

Predicting dynamic, motion-related changes in B field in the brain at a 7T MRI using a subject-specific fine-trained U-net.

Purpose: Subject movement during the MR examination is inevitable and causes not only image artifacts but also deteriorates the homogeneity of the main magnetic field (B ), which is a prerequisite for high quality data. Thus, characterization of changes to B , for example induced by patient movement, is important for MR applications that are prone to B inhomogeneities.

Methods: We propose a deep learning based method to predict such changes within the brain from the change of the head position to facilitate retrospective or even real-time correction.