Publications by authors named "Si Mong Yoon"
Acute severe exacerbation of chronic obstructive pulmonary disease (COPD) is related to high mortality; however, a robust blood biomarker for COPD exacerbation has not been established. Impaired clearance of apoptotic cells is a possible pathogenesis of COPD development. We evaluated the clinical utility of serum cell viability as a predictive biomarker for COPD exacerbation.
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- Cavities in Mycobacterium avium complex pulmonary disease (MAC-PD) indicate a higher disease burden and worse outcomes, but their behavior during treatment is not fully understood.
- In a study of 136 patients treated for MAC-PD, cavity obliteration was linked to a higher rate of microbiological cure (54.4% achieved it after treatment).
- The study found that significant cavity reduction is associated with better outcomes, including lower mortality rates, making cavity changes a potential indicator for treatment response in MAC-PD.
Clinical Efficacy and Safety of an Automatic Closed-Suction System in Mechanically Ventilated Patients with Pneumonia: A Multicenter, Prospective, Randomized, Non-Inferiority, Investigator-Initiated Trial.
Diagnostics (Basel)
May 2024
Endotracheal suctioning is an essential but labor-intensive procedure, with the risk of serious complications. A brand new automatic closed-suction device was developed to alleviate the workload of healthcare providers and minimize those complications. We evaluated the clinical efficacy and safety of the automatic suction system in mechanically ventilated patients with pneumonia.
View Article and Find Full Text PDFAcute Exacerbation and Longitudinal Lung Function Change of Preserved Ratio Impaired Spirometry.
Int J Chron Obstruct Pulmon Dis
February 2024
Article Synopsis
- PRISm (Preserved ratio impaired spirometry) is a complicated lung condition that’s not well-studied in terms of its prevalence or long-term outlook, prompting a comparison with chronic obstructive pulmonary disease (COPD).
- In a study involving 623 patients (40 with PRISm and 583 with COPD), PRISm patients were generally younger, more likely to be female, and had fewer severe illnesses compared to COPD patients, but showed similar risks for acute lung exacerbations.
- Throughout the follow-up period, PRISm patients experienced a slower decline in lung function compared to those with COPD, suggesting a potentially different trajectory in disease progression.
Importance: The prevalence of obesity is increasing in the intensive care unit (ICU). Although obesity is a known risk factor for chronic kidney disease, its association with early sepsis-associated acute kidney injury (SA-AKI) and their combined association with patient outcomes warrant further investigation.
Objective: To explore the association between obesity, early SA-AKI incidence, and clinical outcomes in patients with sepsis.
Incidence and clinical outcomes of bacterial superinfections in critically ill patients with COVID-19.
Front Med (Lausanne)
March 2023
Article Synopsis
- The study investigated the prevalence and impact of bacterial superinfections in critically ill COVID-19 patients in a single ICU from February 2020 to December 2021, with a total of 106 patients analyzed.
- Out of these, 30% developed bacterial superinfections, often with multidrug-resistant bacteria, leading to significant differences in clinical outcomes including fewer ventilator-free days and longer ICU stays.
- Despite the challenges posed by these superinfections on recovery time, no significant differences in mortality rates between patients with and without superinfections were found.
Background: There are limited data on the clinical effects of prone positioning according to lung morphology. We aimed to determine whether the gas exchange response to prone positioning differs according to lung morphology.
Methods: This retrospective study included adult patients with moderate-to-severe acute respiratory distress syndrome (ARDS).