Cascade heteroarylation/annulation of arylphosphonic acid monoesters with benzothiophenes: access to benzothieno-fused oxaphosphacycles.

Sequential C-H/C-H and C-H/O-H cross-dehydrogenative coupling of arylphosphonic acid monoesters with benzothiophenes has been achieved through Ru(II) catalysis to afford benzothieno-fused oxaphosphacycles. This strategy can be extended to the cross-coupling of vinylphosphonic acid monoesters. The site-selectivity, substrate scope, functional group tolerance and photophysical properties of the products are the important features of the reaction.

Directed Cascade C-H Functionalization/2-Fold Annulation with Vinylcyclopropanes: Access to Tetrahydrobenzo[]isochromen-10-ones.

Rh-catalyzed enaminone directed cascade C-H functionalization/2-fold annulation with vinylcyclopropanes has been accomplished to afford functionalized tetrahydrobenzo[]isochromen-10-ones. The sequential C-H/C-C functionalization, C-C/C-O bond formation, redox-neutral conditions, functional group tolerance, and late-stage modification of the natural products are important practical features.

Transition-metal-catalyzed auxiliary-assisted C-H functionalization using vinylcyclopropanes and cyclopropanols.

Transition-metal-catalyzed chelation-assisted C-H functionalization exploiting small strained rings has surfaced as an appealing strategy, offering a robust platform for the construction of complex molecules in a step- and atom-economic fashion. In this vein, three-membered rings, vinylcyclopropanes (VCPs) and cyclopropanols, have emerged as staple coupling partners due to their inherent ring strain. Moreover, their strain release serves as a potent driving force, unlocking new possibilities in molecular engineering sequential C-H functionalization and ring scission.

Integrating C-H activation/2-fold annulation: a modular access to heteroaryl-tethered oxazoloisoquinolinones.

A cascade C-H activation/2-fold annulation of 2-aryloxazolines with pyridotriazoles has been achieved employing Rh-catalysis to afford heteroaryl-tethered oxazoloisoquinolinones. The synergistic annulations, functional group tolerance, and late-stage skeletal editing of the bioactive scaffolds are the salient practical features.

Palladium catalyzed C(sp)-H alkylation of 8-methylquinolines with aziridines: access to functionalized γ-quinolinylpropylamines.

Palladium-catalyzed directed site-selective C(sp)-H alkylation of 8-methylquinolines has been accomplished using aziridine as the alkylating source a sequential C-H and C-N bond activation process. The site selectivity, functional group tolerance and possible late-stage modifications are important practical features of this reaction.

Palladium-Catalyzed Weak Chelation-Assisted Site-Selective C-H Arylation of -Aryl Pyridones via 2-fold C-H Activation.

Palladium-catalyzed weak chelation-assisted oxidative cross-dehydrogenative coupling of arenes has been accomplished. The use of medicinally important pyridones as the intrinsic directing group, regioselectivity, 2-fold C-H activation, and late-stage modification of bioactive compounds are the important practical features.

Biorelevant Weakly Coordinating Directing Group Assisted C-H Alkenylation with Cyclopropanols via Sequential C-H/C-C Activation.

A weakly coordinating biorelevant intrinsic directing group (DG) assisted site-selective C-H alkenylation via sequential C-H/C-C bond activation has been accomplished under Ru(II)-catalysis using readily accessible cyclopropyl alcohol as an alkenyl surrogate. Utilization of an intrinsic DG, exclusive regioselectivity, functional group diversity, late-stage natural product and drug mutations are the important practical features.

A redox-neutral weak carbonyl chelation assisted C4-H allylation of indoles with vinylcyclopropanes.

A weak acyl chelation-assisted distal C4-H allylation of indoles has been accomplished using vinylcyclopropanes as an allylating agent under redox-neutral ruthenium(II) catalysis. The regioselectivity, removable directing group, substrate scope and diastereoselectivity are the important practical features.

C3I-SynFace: A synthetic head pose and facial depth dataset using seed virtual human models.

This article presents C3I-SynFace: a large-scale synthetic human face dataset with corresponding ground truth annotations of head pose and face depth generated using the iClone 7 Character Creator "Realistic Human 100" toolkit with variations in ethnicity, gender, race, age, and clothing. The data is generated from 15 female and 15 male synthetic 3D human models extracted from iClone software in FBX format. Five facial expressions - neutral, angry, sad, happy, and scared are added to the face models to add further variations.

3D face-model reconstruction from a single image: A feature aggregation approach using hierarchical transformer with weak supervision.

Convolutional Neural Networks (CNN) have gained popularity as the de-facto model for any computer vision task. However, CNN have drawbacks, i.e.

Weak Chelation-Assisted C4-Selective Alkylation of Indoles with Cyclopropanols via Sequential C-H/C-C Bond Activation.

A Rh-catalyzed weak chelation-guided C4-alkylation of indoles has been accomplished using cyclopropanols as an alkylating agent via the cascade C-H and C-C bond activation. The substrate scope, functional group tolerance, and late-stage mutation of drug molecules are the important practical features.

Palladium-Catalyzed 2-fold C-H Activation/C-C Coupling for C4-Arylation of Indoles Using Weak Chelation.

Palladium-catalyzed weak chelation-assisted regioselective C4-arylation of indoles has been accomplished using a readily available arene at moderate temperature. The C4-arylation, weak chelating benzoyl (Bz) directing group, cross-dehydrogenative coupling (CDC), broad substrate scope, and late-stage diversifications are the important practical features.

An efficient encoder-decoder model for portrait depth estimation from single images trained on pixel-accurate synthetic data.

Depth estimation from a single image frame is a fundamental challenge in computer vision, with many applications such as augmented reality, action recognition, image understanding, and autonomous driving. Large and diverse training sets are required for accurate depth estimation from a single image frame. Due to challenges in obtaining dense ground-truth depth, a new 3D pipeline of 100 synthetic virtual human models is presented to generate multiple 2D facial images and corresponding ground truth depth data, allowing complete control over image variations.