Impact of flow rate and ratio of endoscope-sheath diameter on stone removal in flexible ureteroscopic lithotripsy: in vitro and CFD analyses insights.

Purpose: To develop a theoretical framework for stone removal in flexible ureteroscopic lithotripsy (FURL) using a soft-tip negative pressure ureteral access sheath (SNP-UAS), we examined how flow rate (FR) and ratio of endoscope-sheath diameter (RESD) affect maximum pull-back speed (max-PBS) through in vitro experiments and computational fluid dynamics (CFD) analyses. Furthermore, we sought to initially clarify the principles behind stone movement in FURL.

Methods: Two sub-studies examined the effects of FR and RESD on PBS during SNP-UAS-assisted FURL while focusing on the principles of stone movement.

Construction and Validation of a Prognostic Model of Metabolism-Related Genes Driven by Somatic Mutation in Bladder Cancer.

Background: Metabolic reprogramming is an important player in the prognosis of cancer patients. However, metabolism-related genes (MRGs) that are essential to the prognosis of bladder cancer (BLCA) are nor yet fully understood. The purpose of this study is to use bioinformatics methods to establish prognostic models based on MRGs in BLCA to screen potential biomarkers.

Rapid exacerbation featuring acute leukemoid reaction after retrolaparoscopic nephrectomy: a rare case report of renal cell carcinoma with postoperative comprehensive genomic profiling.

Background: Rapid lethal exacerbation and recurrence featuring acute leukemoid reaction (ALR) after retrolaparoscopic radical nephrectomy (RN) is a relatively rare clinical incident. Performing the reoperation for the patient and analyzing the tissue-based genetic mutation information postoperatively are a skill-demanding and meaningful task, which have been even more rarely reported.

Case Presentation: We present a case with a large right renal mass (13.