Publications by authors named "Shounak Chattopadhyay"
INFERRING SYNERGISTIC AND ANTAGONISTIC INTERACTIONS IN MIXTURES OF EXPOSURES.
Ann Appl Stat
March 2025
There is abundant interest in assessing the joint effects of multiple exposures on human health. This is often referred to as the mixtures problem in environmental epidemiology and toxicology. Classically, studies have examined the adverse health effects of different chemicals one at a time, but there is concern that certain chemicals may act together to amplify each other's effects.
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- The study aimed to evaluate the relationship between the use of glucagon-like peptide 1 receptor agonists (GLP-1RAs) and the risk of developing thyroid tumors in patients with type 2 diabetes.
- A large cohort analysis included over 460,000 GLP-1RA users compared to users of other diabetes medications, using various statistical methods to ensure accuracy in the findings.
- Results indicated that there was no significant increase in the risk of thyroid tumors for those using GLP-1RAs compared to other diabetes medications, suggesting that GLP-1RAs are not linked to higher thyroid cancer risk.
Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes: A Multinational, Federated Analysis of LEGEND-T2DM.
Rohan Khera
,
Arya Aminorroaya
,
Lovedeep Singh Dhingra
,
Phyllis M Thangaraj
,
Aline Pedroso Camargos
,
Shounak Chattopadhyay
J Am Coll Cardiol
September 2024
Article Synopsis
- This study compares the cardiovascular effectiveness of different second-line antihyperglycemic agents (SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas) in patients with type 2 diabetes and cardiovascular disease.
- Using data from over 1.4 million patients across multiple databases, the researchers analyzed the risk of major adverse cardiovascular events (MACE) over a follow-up period of several years.
- Results indicated that SGLT2 inhibitors and GLP-1 receptor agonists had significantly lower risks of MACE compared to DPP-4 inhibitors and sulfonylureas, pointing to their potential superiority as treatment options for
Comparative Effectiveness of Second-line Antihyperglycemic Agents for Cardiovascular Outcomes: A Large-scale, Multinational, Federated Analysis of the LEGEND-T2DM Study.
Rohan Khera
,
Arya Aminorroaya
,
Lovedeep Singh Dhingra
,
Phyllis M Thangaraj
,
Aline Pedroso Camargos
,
Shounak Chattopadhyay
medRxiv
February 2024
Article Synopsis
- * The study analyzed data from over 1.4 million patients treated with various second-line diabetes medications, using advanced statistical methods to compare outcomes and risks of heart issues.
- * Findings indicated that both SGLT2 inhibitors and GLP-1 receptor agonists reduce the risk of cardiovascular events compared to DPP-4 inhibitors and sulfonylureas, but no significant differences were found between SGLT2is and GLP1-RAs themselves regarding heart risks.