A thioridazine-derived molecule exhibits potential anti-inflammatory activity through IKK inhibition.

Chronic inflammatory diseases are leading causes of morbidity and mortality, necessitating the development of targeted therapeutics with improved safety. Many drugs have been withdrawn from the market because of their off-target effects, particularly hERG inhibition, which leads to severe cardiotoxicity. The NF-κB pathway plays a critical role in inflammation and immune response, making IKKβ an attractive therapeutic target.

Micro-Recycled Carbon Black from Waste Printer Cartridge: A Promising Magnetic Material for Single Stranded DNA Adsorption in SELEX.

The increasing generation of e-waste necessitates innovative strategies for recycling and repurposing, especially for materials with high functional potential. In this study, carbon black (CB) extracted from waste printer toner cartridges is micro-recycled and oxidized into hydrophilic oxidized carbon black (OCB), transforming it into a magnetically active material for single-stranded DNA (ssDNA) adsorption in systematic evolution of ligands by exponential enrichment (SELEX). The developed OCB-SELEX approach successfully overcomes a key limitation in SELEX by enabling magnetic separation of target-bound ssDNA, eliminating nonspecific sequences efficiently.

Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look.

Macrophages play a central role in initiating, maintaining, and terminating inflammation. For that, macrophages respond to various external stimuli in changing environments through signaling pathways that are tightly regulated and interconnected. This process involves, among others, autoregulatory loops that activate and deactivate macrophages through various cytokines, stimulants, and other chemical mediators.