Longitudinal study of Orthohantavirus hantanense in Apodemus agrarius and disease risk assessment in the Republic of Korea during 2000-2019.

Orthohantavirus hantanense (HTNV) is a zoonotic pathogen transmitted by rodents and the causative agent of hemorrhagic fever with renal syndrome (HFRS) in East Asia. Long-term reservoir population ecology studies have enhanced our understanding of hantavirus infection patterns and support disease risk assessments critical for military and civilian populations in HTNV high-risk areas. Here, we evaluated fluctuations in the population dynamics of Apodemus agrarius, the primary reservoir of HTNV, assessed hantavirus seroprevalence, and conducted a descriptive analysis of HFRS disease risks in the Republic of Korea (ROK).

Development of molecular diagnostic tests for marine mammal DNA viruses, herpesvirus, poxvirus, and anellovirus, using a portable biomeme Franklin thermocycler.

Infectious disease-related mass mortality events (ID-MMEs) in marine mammals have increased dramatically over the past 30 years, and viruses have been identified as the primary cause. This study validates the development and utility of point-of-care diagnostics using handheld devices. Using real-time quantitative polymerase chain reaction (real-time qPCR), we developed and validated a portable diagnostic method for detecting viruses infecting marine mammals in field applications.

Detection and characterization of Langya virus in (the Ussuri white-toothed shrew), Republic of Korea.

Langya virus (LayV) is the only documented zoonotic agent within the shrew borne genus. Other species, including Gamak virus and Daeryeong virus, have been discovered in the Republic of Korea, highlighting the prevalence of this genus in the region. We retrospectively analyzed metagenomic next-generation sequencing of two (the Ussuri white-toothed shrew) kidney samples from 2017, followed by paramyxovirus screening of 24 kidney samples from the same species collected in 2023.

Detection and characterization of Langya virus in , Republic of Korea.

This study reports the identification of Langya virus Korea (LayV KOR) during the surveillance of shrews in the Republic of Korea. LayV KOR represents the first identification of LayV outside of China, exhibiting approximately 80% and 95.5% homologies at nucleotide and amino acid levels.

Etiological agent and clinical characteristics of haemorrhagic fever with renal syndrome in the southern Republic of Korea: a genomic surveillance study.

Objectives: High incidences of haemorrhagic fever with renal syndrome (HFRS) have been reported in the southern Republic of Korea (ROK). A distinct southern genotype of Orthohantavirus hantanense (HTNV) was identified in Apodemus agrarius chejuensis on Jeju Island. However, its association with HFRS cases in southern ROK remains elusive.

In vitro broad-spectrum antiviral activity of MIT-001, a mitochondria-targeted reactive oxygen species scavenger, against severe acute respiratory syndrome coronavirus 2 and multiple zoonotic viruses.

The COVID-19 pandemic caused by SARS-CoV-2 becomes a serious threat to global health and requires the development of effective antiviral therapies. Current therapies that target viral proteins have limited efficacy with side effects. In this study, we investigated the antiviral activity of MIT-001, a small molecule reactive oxygen species (ROS) scavenger targeting mitochondria, against SARS-CoV-2 and other zoonotic viruses in vitro.

The relationship between innercanthal dimension and interalar width to the intercanine width of maxillary anterior teeth in central Indian population.

Statement Of Problem: Selection of proper sized maxillary anterior teeth is one of the difficult clinical steps in complete denture esthetics. Several studies have been reported to establish methods of estimating the combined width of maxillary anterior teeth.

Purpose: The aim of this study was to determine whether a relationship exists between the innercanthal distance (ICD) and interalar width (IAW) with the combined width of maxillary anterior teeth.