Publications by authors named "Shinya Fujii"

Music-evoked nostalgia has the potential to assist in recalling autobiographical memories and enhancing well-being. However, nostalgic music preferences vary from person to person, presenting challenges for applying nostalgia-based music interventions in clinical settings, such as a non-pharmacological approach. To address these individual differences, we developed the Nostalgia Brain-Music Interface (N-BMI), a neurofeedback system that recommends nostalgic songs tailored to each individual.

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In opera singing competitions, judges use an overall score to evaluate the singers' voices and determine their rankings. This score not only guides the singers' technique and expressiveness but also serves as a crucial indicator that can significantly influence their careers. However, the specific elements captured by this overall score remain unclear.

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Purpose: To examine magnetic resonance imaging (MRI) features of mesonephric-like adenocarcinoma (MLA) of the uterine corpus.

Method: MRI features of 19 patients with pathologically proven MLA of the uterine corpus were retrospectively compared with those of 95 patients with endometrial endometrioid carcinoma (EEC).

Results: Most patients with MLA were postmenopausal.

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Unsymmetrical 1,1'-disubstituted ferrocene is a versatile scaffold for various functional molecules, including organic electronics, catalysts, and bioactive molecules. Herein, we report a facile synthesis of unsymmetrical 1,1'-disubstituted ferrocene derivatives based on the desymmetrization of 1,1'-diborylferrocene. We found that Suzuki-Miyaura cross-coupling (SMCC) reaction using 1,1'-bis(Bpin)ferrocene affords the mono-substituted product without significant loss of the second boryl group.

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Vitamin D receptor (VDR) is an attractive target of drug discovery for multiple diseases. In this study, we systematically designed and synthesized a series of diphenylsilane derivatives with diverse hydrophobic substituents and investigated their structure-activity relationship (SAR) as VDR agonists. The SAR study revealed that the activity is dependent on the type of substituent and the position of substitution, and the diethyl-di-m-tolylsilane scaffold was identified as the most suitable hydrophobic core structure of this type of VDR ligands.

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Papillary renal neoplasm with reverse polarity (PRNRP) is a distinct subtype of papillary renal tumors first described in 2019. Here, we present the imaging and histopathological findings of two cases of PRNRP. Case 1 involved a 71-year-old man with an incidental right renal mass.

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The sight-over-sound effect, in which visual information dominates auditory cues in musical evaluations, challenges the common belief that sound is the primary factor in music evaluation. However, the replicability of the sight-over-sound effect remains controversial across different musical genres and contexts. Here, we investigated the sight-over-sound effect using recordings from Japanese brass band competitions with carefully controlled musical pieces and camera angles.

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Objective: Adenomyosis, a common gynecologic disease, can cause infertility. Uterine peristalsis (UP) is a wave-like contraction. Abnormal UP has been linked to infertility.

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A 34-year-old woman (gravida 2, para 0) with suspected fetal small-bowel atresia on ultrasound underwent magnetic resonance imaging (MRI) at 33 weeks 3 days of gestation. In addition to small bowel atresia, a teardrop-shaped hematoma was observed adjacent to the umbilical cord associated with an umbilical cord ulcer (UCU). The fetus was delivered by induced labor on diagnosis of intrauterine fetal death.

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Article Synopsis
  • eZIS effectively analyzes brain blood flow patterns, revealing reduced cerebral blood flow in key areas for patients with forgetfulness.
  • SPECT imaging compared patients with mild cognitive impairment (MCI) and early Alzheimer's disease (AD) to controls, uncovering significant differences in blood flow.
  • The study's findings highlight the left insula, operculum, and putamen as critical regions, though the broader implications for clinical treatment remain uncertain.
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Musician's dystonia (MD) is a movement disorder characterized by involuntary muscle contractions specifically triggered by playing an instrument. This condition often leads to a loss of fine motor control, threatening the careers of affected musicians. While MD is commonly associated with the hands, it can also affect the lower limbs, particularly in drummers.

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Glutamatergic dysfunction is involved in the pathophysiology of treatment-resistant depression (TRD). However, few physiological studies have evaluated its pathophysiology in vivo in individuals with TRD. Transcranial magnetic stimulation-electroencephalography (TMS-EEG) techniques can assess intracortical facilitation (ICF), which reflects glutamatergic neurophysiological function in specific cortical regions.

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  • The study aimed to assess how effective new diffusion-weighted imaging (DWI) findings are in diagnosing placenta accreta spectrum (PAS) in pregnant women.
  • Researchers analyzed MRI results from 49 women, identifying features such as diffusion lacunae, which are unique patterns that can indicate PAS.
  • Results showed significant differences in the number and size of these diffusion lacunae between patients with PAS and those without, suggesting that these DWI features, along with flow voids, can improve the accuracy of diagnosing PAS.
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Task-specific focal dystonia (TSFD), characterized by the loss of fine motor control and coordination, affects drummers' lower-limb movements. This study explores lower-limb dystonia's impact on drumming performance and underlying muscle activity in a professional rock drummer. The drummer executed an eight-beat pattern on a drum kit.

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Article Synopsis
  • The study investigates the effectiveness of balloon pulmonary angioplasty (BPA) using intravascular ultrasound (IVUS) to treat total occlusion lesions in chronic thromboembolic pulmonary hypertension without using a conventional guidewire.* -
  • Out of 50 attempted cases, the initial success rate of the procedure was 54%, with the angle of the lesion being the key factor influencing success; post-procedural improvements in blood flow were noted even in 15 out of 23 initially unsuccessful cases.* -
  • The findings suggest that BPA can enhance peripheral blood flow post-procedure despite initial failures, and employing IVUS could be beneficial in optimizing treatment strategies for total occlusion lesions.*
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Hydroboration of vinylsilanes with BH affords two silylethanol regioisomers. Herein, we investigated the regioisomeric ratio of hydroboration products from various vinylsilanes, focusing on the characteristic reaction profile. All investigated vinylsilanes afforded both regioisomers, and greater bulkiness increased the proportion of the Markovnikov products.

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Background: We assessed and compared the image quality of normal and pathologic structures as well as the image noise in chest computed tomography images using "adaptive statistical iterative reconstruction-V" (ASiR-V) or deep learning reconstruction "TrueFidelity".

Methods: Forty consecutive patients with suspected lung disease were evaluated. The 1.

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Article Synopsis
  • Researchers investigated whether a multiparametric scoring system (MSS) could enhance the accuracy of differentiating dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) using brain imaging techniques.
  • The study analyzed imaging data from 23 DLB patients and 57 AD patients, finding that certain Z-scores were significantly lower in DLB patients, while others were higher, indicating distinct imaging patterns between the two conditions.
  • The MSS, which combines multiple imaging parameters, achieved an 82% diagnostic accuracy, surpassing the accuracy of individual imaging techniques in distinguishing between DLB and AD.
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Both music and language are found in all known human societies, yet no studies have compared similarities and differences between song, speech, and instrumental music on a global scale. In this Registered Report, we analyzed two global datasets: (i) 300 annotated audio recordings representing matched sets of traditional songs, recited lyrics, conversational speech, and instrumental melodies from our 75 coauthors speaking 55 languages; and (ii) 418 previously published adult-directed song and speech recordings from 209 individuals speaking 16 languages. Of our six preregistered predictions, five were strongly supported: Relative to speech, songs use (i) higher pitch, (ii) slower temporal rate, and (iii) more stable pitches, while both songs and speech used similar (iv) pitch interval size and (v) timbral brightness.

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Ovarian carcinoid is a rare well-differentiated neuroendocrine tumor resembling those arising in the gastrointestinal tract. We present a case of ovarian carcinoid with magnetic resonance imaging (MRI) findings. A 50-year-old woman with genital bleeding and severe constipation was referred to our hospital.

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Massive perivillous fibrin deposition (MPFD) of the placenta is characterized by the obliteration of the villous trophoblast with extensive deposition of fibrinoid material in the intervillous space. Here, we describe the MRI findings of a case of MPFD. The placenta demonstrates linear and geographical hypointensity on T2-weighted imaging, which is suggested to mainly reflect fibrin deposition.

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We previously revealed that phosphine-boranes can function as molecular frameworks for biofunctional molecules. In the present study, we exploited the diversity of available phosphines to design and synthesize a series of -(trifluoromethyl)phenyl phosphine-borane derivatives as novel progesterone receptor (PR) antagonists. We revealed that the synthesized phosphine-borane derivatives exhibited Log values in a predictable manner and that the P-H group in the phosphine-borane was almost nonpolar.

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