Advances in cancer therapy: a critical review of β-cyclodextrins conjugated nanoparticle delivery systems as molecularly targeted therapies.

Cyclodextrins (CDs), characterized by their hydrophobic inner surface, form inclusion complexes with various organic and inorganic lipophilic compounds. These unique structures enhance the solubility, stability, and bioavailability of poorly soluble drugs. Chemical modifications of the parent CDs (α-CD, β-CD, and γ-CD) improve their suitability for parenteral administration, enabling a wide range of pharmaceutical applications, including drug delivery, cancer therapy, gene delivery, and biosensing.

Pathophysiology of spinal cord injury and advanced therapeutic approaches.

Spinal cord injuries are severe and debilitating, potentially causing permanent neurological losses. Such devastating injuries are associated with limitations in the established treatments, thus demanding some innovative avenues. One among such highly promising approaches concerning tissue-engineered repair in spinal cord injuries (SCI) is the employment of an amalgamation of cells, growth factors, and scaffolds by considering their possible application for regeneration and repair in damaged tissues.

Targeting fungal keratitis: In vivo efficacy of corneal-targeting and non-targeting peptides againstFusarium dimerum.

Fungal keratitis is a major contributor to monocular blindness, globally. This is because, application of conventional topical therapy yields poor outcomes owing to the poor penetration and fungistatic nature of these antifungal agents. Cell penetrating peptides (CPPs) with potent antifungal effect may provide a solution to address these challenges.

Unlocking Dendrimers Future Potential for Brain-Specific Drug Delivery in Cerebroanoreach.

The Blood-Brain Barrier (BBB) makes it extremely difficult to get drugs to the brain, yet highly branching macromolecules known as dendrimers show a lot of promise in this regard. This review delves into the current and future prospects of dendrimers in facilitating brain-specific drug delivery within the framework of cerebroanoreach. The unique structural features of dendrimers allow for precise regulation of surface function, size, and shape, which are critical for targeting specific cell types in the brain and increasing blood-brain barrier permeability.

Optimizing Nutritional Support Through the Retromolar Space.

Maxillofacial trauma resulting from injuries or surgical procedures significantly impacts patient well-being and recovery outcomes. Adequate nutrition is pivotal in wound healing and overall health during the post-injury phase. This technical report explores the critical relationship between nutrition and maxillofacial trauma management.

Nanobiosensors in neurodegenerative disease diagnosis: A promising pathway for early detection.

Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, leading to cognitive and motor impairments. Early diagnosis remains a challenge due to the slow progression of symptoms and the limitations of current diagnostic methods. Nanobiosensors, leveraging the high sensitivity and specificity of nanotechnology, offer a promising, noninvasive, and cost-effective approach for detecting disease biomarkers at ultra-low concentrations.

Pre-emptive Montelukast and Its Effect on Clinical Outcomes After Mandibular Third Molar Surgery: A Triple-blinded Randomized Controlled Trial.

Background: Cyclooxygenase inhibitors are well-studied for pain and swelling control after mandibular third molar extraction, while the lipoxygenase pathway and leukotriene receptor antagonists, like montelukast, remain less researched.

Purpose: The purpose of the study was to measure and compare postoperative pain relief from single pre-emptive doses of montelukast and etoricoxib.

Study Design: The investigators conducted a triple-blinded, placebo-controlled randomized clinical trial and enrolled a sample of patients who presented to the All India Institute of Medical Sciences, Mangalagiri, between January 2023 and April 2023 for evaluation and management of impacted lower third molars.

Advancements in vaccine delivery: harnessing 3D printing for microneedle patch technology.

The development of 3D-printed microneedle (MN) technology is a significant step in vaccine delivery, providing a painless, effective, and adaptable substitute for conventional injection-based techniques. Direct transdermal vaccination distribution without the need for needles is made possible by microneedle patches, which employ a variety of tiny needles that dissolve when they penetrate the skin. By using 3D printing to precisely customise microneedles' size, shape, and density to meet particular vaccine requirements, administration control can be improved and vaccine efficiency may even be increased.

Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis.

Endothelial cells (ECs) lining blood vessels sense disturbed blood flow (D-flow), which drives mitochondrial dysfunction and atherosclerosis. Copper (Cu) is an essential micronutrient, and its disruption of homeostasis has been implicated in atherosclerosis. Cellular Cu levels are tightly controlled by Cu transport proteins including the Cu importer CTR1.

Enhancing cancer care through a knowledge-sharing model: a systematic review of Project ECHO programmes in India.

Background: Cancer poses a life-threatening public health challenge, particularly impacting low- and middle-income countries (LMICs). This study focuses on India, where the cancer burden is substantial, with approximately 1.2 million new cancer cases recorded in 2020, emphasising the urgent need for effective prevention, early detection, treatment, and support services.

Maxillary MRSA osteomyelitis in a paediatric patient: non-surgical management.

Methicillin-resistant (MRSA) osteomyelitis of the maxilla is a rare condition in paediatric patients, with limited evidence available for optimal treatment protocols. We present the case of a paediatric patient in the early childhood age group with post-traumatic maxillary osteomyelitis caused by MRSA. The child developed facial swelling following trauma, and imaging revealed maxillary sinus wall thickening and bone erosions.

TLR4 Targeting: A Promising Therapeutic Approach Across Multiple Human Diseases.

TLR4 stands at the forefront of innate immune responses, recognizing various pathogen- associated molecular patterns and endogenous ligands, thus serving as a pivotal mediator in the immune system's defense against infections and tissue damage. Beyond its canonical role in infection, emerging evidence highlights TLR4's involvement in numerous non-infectious human diseases, ranging from metabolic disorders to neurodegenerative conditions and cancer. Targeting TLR4 signaling pathways presents a promising therapeutic approach with broad applicability across these diverse pathological states.

Analysis of historical data to accelerate deletion of Abnormal Toxicity Test requirement for biologicals and vaccines.

Abnormal Toxicity Test (ATT) is performed as quality control test by manufacturers and National Control Laboratory (NCL) to ensure safety of biologicals. However, stakeholders are in general consensus that extraneous toxic contaminations are extremely unlikely where Good Manufacturing Practices (GMPs) and consistent production have been established. This test requiring mice and guinea pigs is still a regulatory requirement for the batch release of biologicals in several countries although it has been deleted by some National Regulatory Authorities (NRAs) and Pharmacopoeias while some are still working on its elimination.

Myeloid DRP1 deficiency limits revascularization in ischemic muscles via inflammatory macrophage polarization and metabolic reprogramming.

Macrophages play a crucial role in promoting perfusion recovery and revascularization after ischemia through antiinflammatory polarization, a process essential for the treatment of peripheral artery disease (PAD). Mitochondrial dynamics, particularly regulated by the fission protein DRP1, are closely linked to macrophage metabolism and inflammation. However, the role of DRP1 in reparative neovascularization remains unexplored.

Research on Antimicrobial Resistance in the Last 15 Years, India: A Bibliometric Analysis.

Effective antimicrobials play an important element in modern medicine's success in treating infections, without which the patients would be put at risk. Along with the naturally occurring process of antibiotic resistance, the misuse/overuse of these antibiotics also leads to them losing their effectiveness. It limits the treatment options as the microbe that had previously been sensitive becomes resistant.

Endothelial Drp1 Couples VEGF-induced Redox Signaling with Glycolysis Through Cysteine Oxidation to Drive Angiogenesis.

Angiogenesis plays a vital role for postnatal development and tissue repair following ischemia. Reactive oxygen species (ROS) generated by NADPH oxidases (NOXes) and mitochondria act as signaling molecules that promote angiogenesis in endothelial cells (ECs) which mainly relies on aerobic glycolysis for ATP production. However, the connections linking redox signaling with glycolysis are not well understood.

Flavonoids as Potential Natural Compounds for the Prevention and Treatment of Eczema.

Eczema is a systemic autoimmune disease characterized by inflammation and skin manifestation with a range of comorbidities that include physical and psychological disorders. Despite recent advancements in understanding the mechanisms involved in atopic dermatitis, current marketed products have shown varying results with more side effects. The present objective of the research studies is to develop new agents for eczema that cut down the cost of the novel drugs available and also improve the efficacy with the least adverse effects.

RiTe conjugate mediated corneal collagen crosslinking, a novel therapeutic intervention for keratoconus - in vitro and in vivo study.

Corneal collagen crosslinking (CXL) is an effective method to halt the disease progression of keratoconus, a progressive corneal dystrophy leading to cone shaped cornea. Despite the efficacy of standard protocol, the concerning step of this procedure is epithelial debridement performed to facilitate the entry of riboflavin drug. Riboflavin, a key molecule in CXL protocol, is a sparsely permeable hydrophilic drug in corneal tissues.

Theranostic and Combined Approaches Exploiting Multifunctional Gold Nanoclusters in Tumoral Ecosystems: A Paradigm Shift in Precision Oncology.

Malignant tumors pose a significant threat to human life and well-being because of their rising occurrence and size. The current treatment methods and diagnostic techniques employed in clinical practice are inadequate for effectively treating tumors. Fluorescence, photothermal effects, radiosensitization, and biocompatibility are only a few instances of the unique photonic and physicochemical properties exhibited.

Revolutionizing Wound Healing: Unleashing Nanostructured Lipid Carriers Embodied with Herbal Medicinal Plant.

Wound healing is crucial for maintaining skin integrity and preventing complications from external threats. Various plants, such as , Aloe vera, , and Plantago, have demonstrated wound healing capabilities and have been used in herbal medicine for wound care. NLCs are second-generation lipid nanoparticles, blending solid and liquid lipids to improve medication loading and limit leakage.

A Landscape on Lymphatic Filariasis with its Effects and Recent Advanced Treatments.

Lymphatic filariasis is an infection caused by parasites that poses a significant health, social, and economic burden, affecting a vast population that exceeds 120 million individuals globally. The Etiology of the infection is attributed to three nematode parasites, namely Wuchereria bancrofti, B. timori, and Brugia malayi, as well as which are phylogenetically related.

Re-evaluating the Epistemic Authority of Systematic Reviews and Meta-analyses in Contemporary Clinical Discourse.

How to cite this article: Yadav S. Re-evaluating the Epistemic Authority of Systematic Reviews and Meta-analyses in Contemporary Clinical Discourse. J Contemp Dent Pract 2023;24(12):919-920.

An overview of the BCG vaccine and its future scope.

Despite intense elimination efforts, tuberculosis (TB) still poses a threat to world health, disproportionately affecting less developed and poorer countries. The Bacillus Calmette-Guérin (BCG) vaccine, the only anti-TB authorized vaccine can partially stop TB infection and transmission, however, its effectiveness ranges from 0 to 80%. As a result, there is an urgent need for a more potent TB vaccination given the widespread incidence of the disease.

Facilitators and Challenges in Patient's Satisfaction with Quality of Cervical Cancer Care in a Tertiary Care Hospital, Puducherry, India: A Qualitative Study.

Shikha Yadav  Chronic diseases require more attention in terms of patient satisfaction due to their physically and mentally exhausting nature. Cancer burden in India for 2021 was 26.7 million disability-adjusted life years (DALYs), and is projected to rise to 29.