Electrocatalytic Hydrogenation Boosted by Surface Hydroxyls-Modulated Hydrogen Migration over Nonreducible Oxides.

The migration of atomic hydrogen species over heterogeneous catalysts is deemed essential for hydrogenation reactions, a process closely related to the catalyst's functionalities. While surface hydroxyls-assisted hydrogen spillover is well documented on reducible oxide supports, its effect on widely-used nonreducible supports, especially in electrocatalytic reactions with water as the hydrogen source, remains a subject of debate. Herein, a nonreducible oxide-anchored copper single-atom catalyst (Cu/SiO) is designed and uncover that the surface hydroxyls on SiO can serve as efficient transport channels for hydrogen spillover, thereby enhancing the activated hydrogen coverage on the catalyst and favoring the hydrogenation reaction.

cNPAS2 induced β cell dysfunction by regulating KANK1 expression in type 2 diabetes.

Background: Diabetes mellitus type 2 (T2DM) is formed by defective insulin secretion with the addition of peripheral tissue resistance of insulin action. It has been affecting over 400 million people all over the world.

Aim: To explore the pathogenesis of T2DM and to develop and implement new prevention and treatment strategies for T2DM.

Constructing sulfur and oxygen super-coordinated main-group electrocatalysts for selective and cumulative HO production.

Direct electrosynthesis of hydrogen peroxide (HO) via the two-electron oxygen reduction reaction presents a burgeoning alternative to the conventional energy-intensive anthraquinone process for on-site applications. Nevertheless, its adoption is currently hindered by inferior HO selectivity and diminished HO yield induced by consecutive HO reduction or Fenton reactions. Herein, guided by theoretical calculations, we endeavor to overcome this challenge by activating a main-group Pb single-atom catalyst via a local micro-environment engineering strategy employing a sulfur and oxygen super-coordinated structure.

Diagnostic value of circulating microRNAs in thyroid carcinoma: A systematic review and meta-analysis.

Background And Objective: Thyroid cancer (TC) is the most common endocrine system tumour. Several studies had revealed the potential of circulating microRNAs (miRNAs) as novel biomarkers for the diagnosis of TC. The purpose of this meta-analysis is to summarize published studies and evaluate the diagnostic accuracy of circulating miRNAs in TC detection.

[Effect of RYBP Gene Silencing on Sensitivity of HL-60 Cells to Chemotherapeutic Drugs].

Objective: To investigate the effect of RYBP gene on sensitivity of HL-60 cells to chemotherapy drugs by using RNA interference.

Methods: Plasmid expressing RYBP specific shRNA was constructed and then was used to establish the RYBP knockdown stable HL-60 cell line. Q-PCR and Western blot were used to confirm the efficacy of RYBP gene silencing at mRNA and protein level respectively; then the DNA ladder and Annexin V labeled flow cytometry were used to detect cell apoptosis; CCK-8 was used detect the sensitivity of HL-60 cells to the chemotherapeutic drug cytarabine or daunorubicin.

Assessment of the association between XRCC1 Arg399Gln polymorphism and lung cancer in Chinese.

X-ray repair cross-complementing group 1 (XRCC1) is one of the major DNA repair proteins involved in the base excision repair and plays an important role in the maintenance of genomic integrity. Polymorphisms in XRCC1 may alter the function and repair capacity of XRCC1 protein which further results in the genetic instability and lung carcinogenesis. Previous studies investigating the relationship between XRCC1 Arg399Gln polymorphism and lung cancer risk in Chinese yielded contradictory results.