Publications by authors named "Shayan Hosseinzadeh"

Aims: Two-stage exchange arthroplasty is frequently used to treat periprosthetic hip infection. Nevertheless, particularly in high-risk patients, there has been increased attention towards single-surgery options such as 1.5-stage exchange.

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Background: Slipped capital femoral epiphysis (SCFE) is a pediatric hip disorder affecting roughly 1 in 10,000 children and adolescents, with delayed diagnosis and treatment leading to poor outcomes. This study compares the association between presenting hip or knee pain symptomatology and its effects on time to diagnosis and treatment of SCFE, mid- to long-term complications, and risk of requiring hip reconstructive surgeries.

Methods: A retrospective cohort study was conducted comparing SCFE presentations with chief complaints of either hip or knee pain that led to SCFE surgery.

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  • The study investigates how the femoral head moves (translates) in asymptomatic hips and its relationship with hip rotation and anatomy.
  • The researchers hypothesized that translations of the femoral head would be significant and correlated with femoral rotations and hip morphology.
  • Using MRI, they found that the femoral head exhibited notable translations in various positions, and certain translations were statistically significant, suggesting a link between hip geometry and movement patterns.
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Aims: Large bone defects resulting from osteolysis, fractures, osteomyelitis, or metastases pose significant challenges in acetabular reconstruction for total hip arthroplasty. This study aimed to evaluate the survival and radiological outcomes of an acetabular reconstruction technique in patients at high risk of reconstruction failure (i.e.

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Background: Little is known on how meniscal morphology develops during skeletal growth and maturation and its subsequent relationship with the corresponding bony anatomy.

Hypotheses: (1) Meniscal dimensions and morphology would change by age during skeletal growth and maturation in different ways in boys compared with girls. (2) Morphological features of the medial and lateral menisci would correlate to medial and lateral femoral condyle curvatures.

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Background: The 2019 Revised Association Research Circulation Osseous (ARCO) Staging Criteria for Osteonecrosis of the Femoral Head (ONFH) only requires plain radiographs and magnetic resonance imaging (MRI) to diagnose and stage ONFH; however, the effectiveness of the 2019 ARCO criteria in the absence of computed tomography (CT) scans has not been investigated. Therefore, the purpose of this study was to evaluate whether CT scanning is a necessary modality for diagnosing/staging ONFH using the ARCO staging system. More specifically, do CT scans help differentiate pre- and post-collapse lesions more than MRI scans?

Methods: A study was conducted on 228 ONFH patients diagnosed between January 1, 2008, and December 31, 2018, at a single academic medical center.

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Polyelectrolyte coacervates, with their greater-than-water density, low interfacial energy, shear thinning viscosity, and ability to undergo structural arrest, mediate the formation of diverse load-bearing macromolecular materials in living organisms as well as in industrial material fabrication. Coacervates, however, have other useful attributes that are challenging to study given the metastability of coacervate colloidal droplets and a lack of suitable analytical methods. We adopt solution electrochemistry and nuclear magnetic resonance measurements to obtain remarkable insights about coacervates as solvent media for low-molecular-weight catechols.

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  • The study investigates how reduced mechanical forces affect the development of the capital femoral epiphysis in non-ambulatory cerebral palsy (CP) patients, using their hips as a model for abnormal hip loading compared to healthy controls.
  • Utilizing CT images from 98 non-ambulatory CP hips and 80 age-matched controls, researchers measured various morphological features and established a correlation between age and these features.
  • Findings reveal that non-ambulatory CP hips had smaller tubercle dimensions, larger metaphyseal fossa size, and different cupping heights compared to fully weightbearing hips, indicating that mechanical stimulation is crucial for proper growth of the epiphysis.
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Recent investigations suggest that physeal morphologic features have a major role in the capital femoral epiphysis stability and slipped capital femoral epiphysis (SCFE) pathology, with a smaller epiphyseal tubercle and larger peripheral cupping of the femoral epiphysis being present in hips with progressive SCFE compared to healthy controls. Yet, little is known on the causal versus remodeling nature of these associations. This study aimed to use preoperative magnetic resonance imaging (MRI) of patients with unilateral SCFE to perform a comparison of the morphology of the epiphyseal tubercle, metaphyseal fossa, and peripheral cupping in hips with SCFE versus the contralateral uninvolved hips.

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The primary aims of our study were to determine if hospital readmissions within one year following primary total joint arthroplasty (TJA) and their relative timing influence patients' ability to achieve the two-year Patient-Reported Outcomes Measurement Information System (PROMIS) physical, PROMIS mental, and PROMIS Physical-Function-Short-Form-10a (SF-10a) minimal clinically important difference (MCID). This is a retrospective study conducted using data from a multi-institutional, arthroplasty registry. Only patients with paired patient-reported outcome measure (PROM) assessments (preoperatively and two years postoperatively) were included.

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Introduction: Acetabular reconstruction is a challenging problem in orthopaedic oncology, especially in extended defects (Paprosky Type 3A and Type 3B). In revision total hip arthroplasty (THA), 1 option is trabecular metal (TM) augments with a porous metal acetabular component. This study evaluated the use of TM augments in periacetabular malignant bone disease.

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  • The study assessed the impact of the COVID-19 pandemic on infection rates related to total joint arthroplasty (TJA), comparing data from three years before the pandemic to the year 2020.
  • Despite evaluating a total of over 20,000 TJA patients, the study found no significant differences in the rates of peri-prosthetic joint infections (PJI) and superficial surgical site infections (SSI) between the pre-pandemic and pandemic cohorts.
  • The findings suggest that while there were no major changes in infection rates, ongoing adherence to hygiene practices and safety measures is crucial during such health crises.
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  • Single-cell RNA sequencing (scRNA-seq) combined with RNA velocity and metabolic labeling provides detailed insights into how cells change states and transition over time.
  • The dynamo framework is introduced as a tool that enhances the analysis of scRNA-seq data by inferring RNA velocity, predicting cell fates, and identifying key regulatory mechanisms using advanced mathematical techniques.
  • Dynamically demonstrating its effectiveness, dynamo helps uncover the processes behind platelet cell formation and predicts how changes in gene activity can influence cell fates, marking a significant advancement in understanding cell state transitions.
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We sought to determine postoperative opioid consumption for opioid-naïve patients undergoing total knee and hip arthroplasty (THA and TKA) procedures via an observational cohort study, consisting of 55 patients who underwent either primary unilateral TKA (n = 28) or THA (n = 27). Patients were provided with a journal to track daily consumption of pain medicine. Patients were prescribed an average of 67 opioid pills post-operatively; however, they consumed an average of 31 pills (214 morphine equivalent doses - MED).

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Introduction: A comprehensive comparison of the performance of different femoral stem geometries in total hip arthroplasty (THA) is yet to be described. The primary aim of this study was to evaluate objective and subjective outcome measures in primary THA with different femoral implant styles.

Methods: Stems were classified into the following five classes: cemented, conical, fit and fill, modular, and wedge.

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Plaster of Paris (PoP) has been the predominant treatment option for most acute and chronic orthopedic conditions. Water immersion significantly decreases the PoP bandage strength. Moreover, concerns have been raised about the possibility of breaks in PoP splints and cast failures once solid.

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Dupuytren's contracture is a common hand pathology for which consultation and treatment are largely at the patient's discretion. The objective of this study was to evaluate the readability of current online patient information regarding Dupuytren's contracture. The largest public search engines (Google, Yahoo, and Bing) were queried using the search terms "Dupuytren's contracture," "Dupuytren's disease," "Viking's disease," and "bent finger.

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Previous studies have demonstrated that blood glucose (BG) levels should be monitored for at least 1 week after orthopaedic surgery in diabetic patients, but no study has determined how long nondiabetic patients should be monitored. As postoperative elevations in BG have deleterious effects, determining a duration for monitoring the BG of nondiabetic patients after major orthopaedic surgery is needed to detect hyperglycemic events, create comprehensive protocols for nondiabetic orthopaedic patients, and reduce adverse outcomes. A retrospective study was conducted including consecutive patients who underwent a major orthopaedic surgery at a community hospital.

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