LPS mediated neuronal c-Fos activation: whole-brain mapping, site and time effect in intoxicated mice.

Lipopolysaccharide (LPS; a bacterial endotoxin) treatment causes acute inflammatory conditions. Acute inflammation causes the brain to activate neurons in some brain nuclei known as circumventricular organs. The c-Fos immunoreaction could be used to assess this neural activity.

Immune-antioxidant responses, autophagy, endoplasmic reticulum stress, resistance to Aeromonas sobria in Nile tilapia under arsenic exposure: The mitigating role of a genistein-fortified diet.

The immune system of fish is severely impacted by heavy metal pollutants that enter the aquatic system, reducing their survival and resistance to diseases. Arsenic is a widespread heavy metal that contaminates aquatic bodies, impacts fish health, and hinders the sustainability of aquaculture. In the current investigation, we studied the arsenic-hazard consequences on the hematology, serum immunological responses, antioxidant activity, autophagy-related genes, splenic architecture, and protection against Aeromonas sobria in Nile tilapia (Oreochromis niloticus).

Impacts of -loaded chitosan nanoparticles against indomethacin induced peptic ulcer in rats: promising therapy with enhanced bioavailability and gastro-protective activity.

Peptic ulcer is a chronic inflammatory disorder affecting large portion of population with difficulty in treatment. Treatment options include inhibition of gastric acid secretion, histamine inhibitors, eradication of infection and tissue lining protection. These therapeutic options have several side effects, low bioavailability and bio-distribution.

Thymoquinone loaded zinc oxide Nanoformulations synthesis, characterization and evaluation of their efficacy against carbon tetrachloride induced Hepatorenal toxicity in rats.

Thymoquinone (THQ), a strong antioxidant and anti-inflammatory bioactive compound has been reported in numerous studies to prevent the hepatorenal toxicity caused by various xenobiotics. Similarly, the zinc oxide nanoparticles (ZnONPs) have been used to protect against the hepatorenal damages caused by oxidative stress due to their potent antioxidant properties. The aim of this study was to synthesize and investigate the possible protective effects of THQ, ZnONPs and THQ-loaded ZnONPs against CCl induced hepatorenal toxicity in albino rats.

Ameliorative impacts of Sinapic acid against monosodium urate crystal-induced gouty arthritis and inflammation through different signaling pathways.

As known, gout a metabolic disease due to the urate crystals deposition in the joints and affect human health and state. Humans are looking for safe natural remedies from plants with safe, low cost and high effect on their health. Sinapic acid (SA) is found in plants and used as phytoconstituent in human diets.

Mitigative Effects of l-Arginine and N-Acetyl Cysteine against Cisplatin-Induced Testicular Dysfunction and Toxicity through the Regulation of Antioxidant, Anti-inflammatory, and Antiapoptotic Markers: Role of miR-155 and miR-34c Expression.

Testicular dysfunction is a common adverse effect of cisplatin (CIS) administration as a chemotherapeutic drug. The current study has outlined the role of micro-RNAs (miR-155 and 34c) in CIS-induced testicular dysfunction and evaluated the protective effect of N-acetyl cysteine (NAC) and/or l-arginine (LA). Seven groups of Albino rats were used for this study.

Ameliorative impacts of astaxanthin against atrazine-induced renal toxicity through the modulation of ionic homeostasis and Nrf2 signaling pathways in mice.

Astaxanthin (ASX), a red pigment belonging to carotenoids, has antioxidant activity and anti-oxidative stress effect. Atrazine (ATZ), a frequently used herbicide, whose degradation products are the cause for nephrosis and other oxidative stress associated diseases. This study was aimed to reveal the potential protective mechanism of astaxanthin against atrazine-induced nephrosis.

Screening impacts of Tilmicosin-induced hepatic and renal toxicity in rats: protection by Rhodiola rosea extract through the involvement of oxidative stress, antioxidants, and inflammatory cytokines biomarkers.

Tilmicosin (TIL) is a semisynthetic macrolide antibiotic with a broad spectrum of activity derived from tylosin. TIL is effective in the treatment of bovine and ovine respiratory diseases caused by different microbes. In parallel, Rhodiola rosea (RHO) is a popular herbal remedy because of its anti-inflammatory and antioxidant qualities.