Publications by authors named "Shashikant Saini"

Background: Nosocomial fever of unknown origin (nFUO) is a frequent and challenging diagnostic entity, encompassing diverse infectious and non-infectious etiologies. Timely identification is crucial, yet evidence on the diagnostic accuracy of commonly employed sepsis screening tools and biomarkers remains sparse. We hypothesized that these tools and biomarkers measured at fever onset could distinguish infectious from non-infectious causes of nFUO in critically ill adults.

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A 15 year old boy was detected to have bilateral renomegaly when he was being evaluated for nausea. Kidney biopsy done revealed interstitial infiltration by blasts in sheets. PET scan done revelaed diffuse uptake in bilaterally enlarged kidneys.

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Article Synopsis
  • - This study investigates the prevalence and prognosis of secondary hemophagocytic lymphohistiocytosis (sHLH) in adult scrub typhus patients in North India, finding it affects 18.7% of patients.
  • - Key diagnostic factors include high-grade fever, seizures, and elevated ferritin levels, with ferritin showing the strongest correlation (AUC 0.83) for diagnosing sHLH.
  • - The research highlights that patients with sHLH have a significantly higher in-hospital mortality rate (21.4%) compared to those without (6.6%), stressing the importance of early detection for better management.
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β-Thalassaemia, the most common monogenic disorder, is characterized by genetic heterogeneity at the molecular level. More than 300 mutations of the β globin gene have been characterized all over the world, however, few common mutations account for majority of the cases in various populations. The present study aimed to screen known cases of β-thalassaemia in the Western part of Rajasthan state for five common mutations.

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Ewing's sarcoma family of tumours include both peripheral primitive neuroectodermal tumour (PNET) and Ewing's sarcoma including both intraosseous and extra osseous sites. Rarest of all is the involvement of liver as primary site, of which only 4 case reports have been published. We report a very rare case of 4 year old male child with primary Ewing's Sarcoma in the liver along with review of literature.

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Aims: To determine the factors influencing awareness about beta-thalassemia in the population.

Settings And Design: A cross sectional study was conducted by the Department of Pathology, AIIMS, Jodhpur.

Methods And Material: The study population included participants with medical as well as non-medical background, to ensure representation of all sections of the society.

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For clinically low-volume breast cancer patients subjected to BCS, there is a concern regarding achieving microscopically negative margins and avoiding inadvertent resection of excessive volume of breast tissue. In this study, we utilized intraoperative ultrasound to guide resection in patients subjected to BCS. This was compared with palpation-guided resection.

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Background: Anastomosis in gastrointestinal (GI) surgery is a commonly performed procedure. Irrelevant various methods of intestinal anastomosis were followed - recent advance is the use of a stapler as a device for GI anastomosis. Due to the use of staplers, technical failures are a rarity, anastomosis is more consistent and can be used at difficult locations.

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Background: Breast cancer is the most common cancer in women and second most common type of cancer overall. The prime objectives of axillary surgery in the management of breast cancer are 1) accurate staging, 2) treatment to cure and 3) quantitative information of metastatic lymph nodes for prognostic purposes and allocation to adjuvant protocols. During axillary dissection, all 3 level lymphnodes are removed, while the important axillary structures (axillary vein, long thoracic and thoracodorsal nerves) are preserved.

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Synovial sarcoma (SS) of oral cavity is very rare tumor. Only 3-10% of all synovial sarcomas originate in the head and neck. It is more commonly seen in young male population.

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