Slurry Synthesis and Thin-Film Fabrication Toward Production of Li₂O-B₂O₃-Al₂O₃-Based Multilayer Oxide Solid-State Batteries for Internet of Things Applications.

Developing thin-film sheets made of oxide-based solid electrolytes is essential for fabricating surface-mounted ultracompact multilayer oxide solid-state batteries. To this end, solid-electrolyte slurry must be optimized for excellent dispersibility. Although oxide-based solid electrolytes for multilayer structures require sintering, high processing temperatures cause problems such as Li-ion volatilization and reactions with graphite anodes.

The Impact of Calcium Depletion on Proliferation of Strain DSCG150.

This study analyzed the effects of Ca metal ions among culture medium components on the strain DSCG150 strain cell growth. The strain DSCG150 grew based on a multiple fission cell cycle and growth became stagnant in the absence of metal ions in the medium, particularly Ca. Flow cytometry and confocal microscopic image analysis results showed that in the absence of Ca, cell growth became stagnant as the cells accumulated into four autospores and could not transform into daughter cells.

A Portable Diagnostic Assay, Genetic Diversity, and Isolation of Seoul Virus from Collected in Gangwon Province, Republic of Korea.

Seoul virus (SEOV), an etiological agent for hemorrhagic fever with renal syndrome, poses a significant public health threat worldwide. This study evaluated the feasibility of a mobile Biomeme platform for facilitating rapid decision making of SEOV infection. A total of 27 were collected from Seoul Metropolitan City and Gangwon Province in Republic of Korea (ROK), during 2016-2020.

Enhancing neutralizing activity against influenza H1N1/PR8 by engineering a single-domain VL-M2 specific into a bivalent form.

Flu disease, with high mortality and morbidity, is caused by the influenza virus. Influenza infections are most effectively prevented through vaccination, but it requires annual reformulation due to the antigenic shift or drift of hemagglutinin and neuraminidase proteins. Increasing resistance to available anti-influenza drugs was also recently reported.

Clinical and Immunological Predictors of Hemorrhagic Fever with Renal Syndrome Outcome during the Early Phase.

The ability to accurately predict the early progression of hemorrhagic fever with renal syndrome (HFRS) is crucial for reducing morbidity and mortality rates in severely affected patients. However, the utility of biomarkers for predicting clinical outcomes remains elusive in HFRS. The aims of the current study were to analyze the serum levels of immune function-related proteins and identify novel biomarkers that may help ascertain clinical outcomes of HFRS.

Genotyping and Molecular Diagnosis of Hepatitis A Virus in Human Clinical Samples Using Multiplex PCR-Based Next-Generation Sequencing.

Hepatitis A virus (HAV) is a serious threat to public health worldwide. We used multiplex polymerase chain reaction (PCR)-based next-generation sequencing (NGS) to derive information on viral genetic diversity and conduct precise phylogenetic analysis. Four HAV genome sequences were obtained using multiplex PCR-based NGS.

Discovery and Genetic Characterization of Novel Paramyxoviruses Related to the Genus in Species in the Republic of Korea.

Paramyxoviruses, negative-sense single-stranded RNA viruses, pose a critical threat to human public health. Currently, 78 species, 17 genera, and 4 subfamilies of paramyxoviruses are harbored by multiple natural reservoirs, including rodents, bats, birds, reptiles, and fish. Henipaviruses are critical zoonotic pathogens that cause severe acute respiratory distress and neurological diseases in humans.

Urinary genome detection and tracking of Hantaan virus from hemorrhagic fever with renal syndrome patients using multiplex PCR-based next-generation sequencing.

Background: Hantavirus infection occurs through the inhalation of aerosolized excreta, including urine, feces, and saliva of infected rodents. The presence of Hantaan virus (HTNV) RNA or infectious particles in urine specimens of patient with hemorrhagic fever with renal syndrome (HFRS) remains to be investigated.

Methodology/principal Findings: We collected four urine and serum specimens of Republic of Korea Army (ROKA) patients with HFRS.

Novel Paju Apodemus paramyxovirus 1 and 2, harbored by Apodemus agrarius in the Republic of Korea.

Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.

Multiplex PCR-Based Nanopore Sequencing and Epidemiological Surveillance of in , Republic of Korea.

Whole-genome sequencing of infectious agents enables the identification and characterization of emerging viruses. The MinION device is a portable sequencer that allows real-time sequencing in fields or hospitals. (Hantaan virus, HTNV), harbored by , causes hemorrhagic fever with renal syndrome (HFRS) and poses a critical public health threat worldwide.

A novel genotype of Hantaan orthohantavirus harbored by Apodemus agrarius chejuensis as a potential etiologic agent of hemorrhagic fever with renal syndrome in Republic of Korea.

Background: Orthohantaviruses, causing hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome, pose a significant public health threat worldwide. Despite the significant mortality and morbidity, effective antiviral therapeutics for orthohantavirus infections are currently unavailable. This study aimed to investigate the prevalence of HFRS-associated orthohantaviruses and identify the etiological agent of orthohantavirus outbreaks in southern Republic of Korea (ROK).

Broad-Spectrum Antiviral Activity of 3D8, a Nucleic Acid-Hydrolyzing Single-Chain Variable Fragment (scFv), Targeting SARS-CoV-2 and Multiple Coronaviruses In Vitro.

The virus behind the current pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the etiology of novel coronavirus disease (COVID-19) and poses a critical public health threat worldwide. Effective therapeutics and vaccines against multiple coronaviruses remain unavailable. Single-chain variable fragment (scFv), a recombinant antibody, exhibits broad-spectrum antiviral activity against DNA and RNA viruses owing to its nucleic acid-hydrolyzing property.

A Clinical Case of Scrub Typhus in the United States Forces Korea Patient with Eschar and Genetic Identification of Using Multiplex PCR-Based Next-Generation Sequencing.

An epidemiological investigation was conducted for a scrub typhus case reported in a U.S. Forces Korea military patient in the Republic of Korea in November 2018.

Genomic Epidemiology and Active Surveillance to Investigate Outbreaks of Hantaviruses.

Emerging and re-emerging RNA viruses pose significant public health, economic, and societal burdens. Hantaviruses (genus , family , order ) are enveloped, negative-sense, single-stranded, tripartite RNA viruses that are emerging zoonotic pathogens harbored by small mammals such as rodents, bats, moles, and shrews. Orthohantavirus infections cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome in humans (HCPS).

Phylogeographic diversity and hybrid zone of Hantaan orthohantavirus collected in Gangwon Province, Republic of Korea.

Background: Hantaan orthohantavirus (Hantaan virus, HTNV), harbored by Apodemus agrarius (the striped field mouse), causes hemorrhagic fever with renal syndrome (HFRS) in humans. Viral genome-based surveillance at new expansion sites to identify HFRS risks plays a critical role in tracking the infection source of orthohantavirus outbreak. In the Republic of Korea (ROK), most studies demonstrated the serological prevalence and genetic diversity of orthohantaviruses collected from HFRS patients or rodents in Gyeonggi Province.

Fabrication of TiB-Al1050 Composites with Improved Microstructural and Mechanical Properties by a Liquid Pressing Infiltration Process.

This study was conducted on titanium diboride (TiB) reinforced Al metal matrix composites (MMCs) with improved properties using a TiB and aluminum (Al) 1050 alloy. Al composites reinforced with fine TiB at volume ratios of more than 60% were successfully fabricated via the liquid pressing infiltration (LPI) process, which can be used to apply gas pressure at a high temperature. The microstructure of the TiB-Al composite fabricated at 1000 °C with pressurization of 10 bar for 1 h showed that molten Al effectively infiltrated into the high volume-fraction TiB preform due to the improved wettability and external gas pressurization.

Comparison of targeted next-generation sequencing for whole-genome sequencing of Hantaan orthohantavirus in Apodemus agrarius lung tissues.

Orthohantaviruses, negative-sense single-strand tripartite RNA viruses, are a global public health threat. In humans, orthohantavirus infection causes hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome. Whole-genome sequencing of the virus helps in identification and characterization of emerging or re-emerging viruses.

Microstructural Evolution and Strengthening Mechanism of SiC/Al Composites Fabricated by a Liquid-Pressing Process and Heat Treatment.

Aluminum alloy (Al7075) composites reinforced with a high volume fraction of silicon carbide (SiC) were produced by a liquid-pressing process. The characterization of their microstructure showed that SiC particles corresponding to a volume fraction greater than 60% were uniformly distributed in the composite, and MgSi precipitates were present at the interface between the matrix and the reinforcement. A superior compressive strength (1130 MPa) was obtained by an effective load transfer to the hard ceramic particles.

Effect of Intermetallic Compounds on the Thermal and Mechanical Properties of Al⁻Cu Composite Materials Fabricated by Spark Plasma Sintering.

Aluminium-copper composite materials were successfully fabricated using spark plasma sintering with Al and Cu powders as the raw materials. Al-Cu composite powders were fabricated through a ball milling process, and the effect of the Cu content was investigated. Composite materials composed of Al-20Cu, Al-50Cu, and Al-80Cu (vol.

Semisolid State Sintering Behavior of Aluminum⁻Stainless Steel 316L Composite Materials by Powder Metallurgy.

Aluminum (Al)-stainless steel 316L (SUS316L) composites were successfully fabricated by the spark plasma sintering process (SPS) using pure Al and SUS316L powders as raw materials. The Al-SUS316L composite powder comprising Al with 50 vol.% of SUS316L was prepared by a ball milling process.

Active Targeted Surveillance to Identify Sites of Emergence of Hantavirus.

Background: Endemic outbreaks of hantaviruses pose a critical public health threat worldwide. Hantaan orthohantavirus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS) in humans. Using comparative genomic analyses of partial and nearly complete sequences of HTNV from humans and rodents, we were able to localize, with limitations, the putative infection locations for HFRS patients.

Behavior of Intermetallic Compounds of Al-Ti Composite Manufactured by Spark Plasma Sintering.

In this research, we successfully fabricate high-hardness and lightweight Al-Ti composites. Al-Ti composites powders with three compositions (Al-20, 50, and 80 vol.% Ti) are mixed using ball milling and subsequently subjected to spark plasma sintering (SPS).

Aluminum-ceramic composites for thermal management in energy-conversion systems.

The most important property of energy-conversion ceramics in high-power lighting devices based on laser diodes (LDs) is thermal durability because high-energy LDs act as excitation and heat sources for ceramics. Herein, aluminum-ceramic composites (ACCs) are introduced for the manipulation of heat generated during high-power lighting. The cerium-doped aluminum garnet (YAG:Ce) phosphor is selected as the energy-conversion ceramic material.

Complete Genome Sequence of Lactobacillus reuteri SKKU-OGDONS-01, Isolated from a Chicken's Small Intestine.

Lactobacillus reuteri SKKU-OGDONS-01 is a potentially indigenous probiotic strain isolated from the small intestine of a 27-week-old chicken. The complete genome of L. reuteri SKKU-OGDONS-01 comprises a single circular chromosome.