Tri-Layered Full-Thickness Artificial Skin Incorporating Adipose-Derived Stromal Vascular Fraction Cells, Keratinocytes, and a Basement Membrane.

Tissue-engineered artificial skin has the potential to enhance wound healing without necessitating extensive surgical procedures or causing donor-site morbidity. The purpose of this study was to examine the possibility of developing tri-layered tissue-engineered full-thickness artificial skin with a basement membrane for clinical use to accelerate wound healing. We engineered full-thickness artificial skin with a basement membrane for wound healing by employing stromal vascular fraction (SVF) cells for the dermal layer and autologous keratinocytes for the epidermal layer.

Biomimetic Full-Thickness Artificial Skin Using Stromal Vascular Fraction Cells and Autologous Keratinocytes in a Single Scaffold for Wound Healing.

We developed biomimetic full-thickness artificial skin using stromal vascular fraction (SVF) cells and autologous keratinocytes for the dermal and epidermal layers of skin, respectively. Full-thickness artificial skin scaffolds were fabricated using 4% porcine collagen and/or elastin in a low-temperature three-dimensional printer. Two types of scaffolds with collagen-to-elastin ratios of 100:0 and 100:4 were printed and compared.

Association of Striatal Dopaminergic Depletion and Cerebral Perfusion With Cognition in Brain-First and Body-First Parkinson's Disease.

Purpose: We aimed to investigate whether the patterns of striatal subregional dopamine loss and cerebral perfusion alterations differed between the 2 types of Parkinson's disease (PD) (ie, brain-first and body-first PD) and had an impact on cognitive prognosis in PD.

Patients And Methods: This retrospective study reviewed the data of newly diagnosed patients with PD who underwent dual-phase dopamine transporter (DAT) scans in tertiary medical centers. We classified the patients into 2 groups based on the rapid eye movement sleep behavior disorder (RBD) screening questionnaire: PD with RBD (body-first PD) and PD without RBD (brain-first PD) groups.

Septorhinoplasty Using Septal L-Strut Extension Graft: A Long-Term Multi-Dimensional Analysis.

Background: Nasal dorsal augmentation using an alloplastic implant and tip projection using a septal cartilage are generally used in Asian rhinoplasty. Excessive submucosal resection weakens septal support, causing problems by a heavy alloplastic implant on the nasal dorsum. If the anterior projection of the cartilaginous dorsum can be solved by cartilage grafts, the amount of dorsal onlaying can be reduced.

Creating a Practical Tool for Predicting Major Amputation Rate in Patients With Diabetic Hindfoot Ulcers: Focus on Ischemia and Infection.

Background: Patients with diabetic hindfoot ulcers typically harbor significant concerns regarding their prospects for healing or the potential for major amputation. Nonetheless, a scarcity of data addressing this prevalent and critical query exists. Thus, the aim of this study was to create an initial risk-scoring system to forecast the prognosis of individuals with diabetic hindfoot ulcers, leveraging assessments of ischemia and infection severity, which are recognized as the principal risk factors for amputation.

Diagnosis of carpal tunnel syndrome using deep learning with comparative guidance.

Objective: This study aims to develop a deep learning model for a robust diagnosis of Carpal Tunnel Syndrome (CTS) based on comparative classification leveraging the ultrasound images of the thenar and hypothenar muscles.

Methods: We recruited 152 participants, both patients with varying severities of CTS and healthy individuals. The enrolled patients underwent ultrasonography, which provided ultrasound image data of the thenar and hypothenar muscles from the median and ulnar nerves.

Scar changes over time after artificial dermis grafting for full-thickness temporal defects following skin cancer excision: A colorimetric and anthropometric study.

Advances in biotechnology have introduced artificial dermis as an alternative to autologous tissue reconstruction. Our group has employed artificial dermis grafting for full-thickness temporal defects to overcome the limitations of traditional reconstructive methods, such as local flaps and skin grafts. This study evaluates the changes in colour matching and the degree of scar contraction following artificial dermis grafting and explores its potential for reconstructing such defects.

Comparison of Tissue-Engineered Dermis with Micronized Adipose Tissue and Artificial Dermis for Facial Reconstruction Following Skin Cancer Resection.

Our group has previously demonstrated that tissue-engineered dermis containing cultured fibroblasts or adipose-derived stromal vascular fraction cells is superior to artificial dermis in terms of scar quality for covering facial defects. However, using these cells for clinical applications requires Food and Drug Administration approval and involves complex procedures for cell culture or isolation. This retrospective study aimed to compare effects of tissue-engineered dermis containing micronized adipose tissue (MAT) and artificial dermis for facial reconstruction.

Drug Repositioning and Repurposing for Disease-Modifying Effects in Parkinson's Disease.

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder and is characterized by progressive dopaminergic and nondopaminergic neuronal loss and the presence of Lewy bodies, which are primarily composed of aggregated α-synuclein. Despite advancements in symptomatic therapies, such as dopamine replacement and deep brain stimulation, no disease-modifying therapies (DMTs) have been identified to slow or arrest neurodegeneration in patients with PD. Challenges in DMT development include disease heterogeneity, the absence of reliable biomarkers, and the multifaceted pathophysiology of PD, encompassing neuroinflammation, mitochondrial dysfunction, lysosomal impairment, and oxidative stress.

Artificial Dermis Graft Following Basal Cell Carcinoma Removal on the Nose: A Comparison of Scar Contracture Across Nasal Subunits.

Background: This study aimed to compare the degree of scar contracture following artificial dermis grafting after excision of basal cell carcinoma on the nose categorized by defect location into three nasal subunits.

Methods: Anthropometric analysis was conducted on seven parameters using patients' photographs to compare changes between preoperative and postoperative measurements based on nasal subunits. Defect locations were classified as: (1) dorsum and sidewalls (D zone), (2) tip (T zone), and (3) alar lobule (A zone).

Occipital hypoperfusion and motor reserve in Parkinson's disease: an early-phase F-FP-CIT PET study.

Individual variability exists in parkinsonian motor symptoms despite a similar degree of nigrostriatal dopamine depletion in Parkinson's disease (PD), called motor reserve. We enrolled 397 patients newly diagnosed with PD who underwent dual-phase F-FP-CIT PET upon initial assessment. Individual motor reserve was estimated based on initial parkinsonian motor symptoms and striatal dopamine transporter availability using a residual model.

Association between striatal amyloid deposition and motor prognosis in Parkinson's disease.

Background And Purpose: The co-occurrence of amyloid-β pathology in Parkinson's disease (PD) is common; however, the role of amyloid-β deposition in motor prognosis remains elusive. This study aimed to investigate the association between striatal amyloid deposition, motor complications and motor prognosis in patients with PD.

Methods: Ninety-six patients with PD who underwent F florbetaben (FBB) positron emission tomography were retrospectively assessed.

Immunosuppressive therapy in elderly patients with neuromyelitis optica spectrum disorder: a retrospective multicentre study.

Background: The risk-benefit relationship of immunosuppressive therapies (ISTs) for elderly patients with neuromyelitis optica spectrum disorder (NMOSD) is not well established. This study aimed to investigate the safety and efficacy of IST in elderly patients with NMOSD.

Methods: This retrospective study analysed IST efficacy and safety in 101 patients with aquaporin-4 antibody-positive NMOSD aged over 65 years, treated for at least 6 months at five Korean referral centres, focusing on relapse rates, infection events and discontinuation due to adverse outcomes.

Evaluating micronized adipose tissue niche and artificial dermis grafts following nonmelanoma skin cancer excision: a pilot study.

Background: Recently, micronized adipose tissue (MAT) grafts have shown promising results in wound healing, including diabetic ulcers.

Objective: To assess the possibility of using 3D printed MAT niche grafts in the management of skin and soft tissue defects resulting from non-melanoma skin cancer (NMSC) resections.

Materials And Methods: A retrospective feasibility study was conducted on patients with skin and soft tissue defects resulting from NMSC resections.

Myomucosal composite graft: A simple technique for full-thickness vermilion defects of the lower lip.

Reconstruction of vermillion defects of the lower lip requires careful consideration of functional and aesthetic aspects. Traditionally, various local flap methods involving tissue advancement from the corner of the mouth, lateral chin, and medial cheek have been commonly employed to fill lower lip defects. However, these approaches have inherent limitations, which include technical complexity, disruption of the orbicularis oris muscle, lip tightening, microstomia, and visible scarring.

Choroid Plexus Volume, Amyloid Burden, and Cognition in the Alzheimer's Disease Continuum.

As a part of the glymphatic system, the choroid plexus (CP) is involved in the clearance of harmful metabolites from the brain. We investigated the association between CP volume (CPV), amyloid-β (Aβ) burden, and cognition in patients on the Alzheimer's disease (AD) continuum. We retrospectively reviewed the records of 203 patients on the AD continuum and 82 healthy controls who underwent brain magnetic resonance imaging and F-florbetaben positron emission tomography.

Differential effects of cholesterol levels on cognition according to body mass index in Parkinson's disease.

Background: Cholesterol is an essential component of the neuronal cell membrane and is crucial for neuronal function; however, the role of cholesterol levels in Parkinson's disease (PD) is debatable. This study investigated the complex relationship between total cholesterol (TC) levels, body mass index (BMI), and cognition in patients with PD.

Methods: This study included 321 drug-naïve patients with PD who underwent dopamine transporter (DAT) imaging and baseline neuropsychological tests.

Different effect of hypo- and hypermetabolism on cognition in dementia with Lewy bodies: are they coupled or independent?

Patients with dementia with Lewy bodies (DLB) show widespread brain metabolic changes. This study investigated whether brain hypo- and hypermetabolism in DLB have differential effects on cognition. We enrolled 55 patients with DLB (15 prodromal DLB [MCI-LB] and 40 probable DLB) and 13 healthy controls who underwent F-fluorodeoxyglucose positron emission tomography and detailed neuropsychological tests.

Association Between Menopausal Hormone Therapy and Risk for Parkinson's Disease.

Background: The relationship between menopausal hormone therapy (MHT) and risk of Parkinson's disease (PD) remains controversial.

Objective: This nationwide population-based cohort study investigated the association between MHT and PD development.

Methods: Data from the National Health Insurance System of South Korea from 2007 to 2020 were used.

Hippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson Disease: An Early Phase F-FP-CIT Positron Emission Tomography Study.

Objective: We investigated whether hippocampal perfusion changes are associated with cognitive decline, motor deficits, and the risk of dementia conversion in patients with Parkinson disease (PD).

Methods: We recruited patients with newly diagnosed and nonmedicated PD and healthy participants who underwent dual phase F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scans. Patients were classified into 3 groups according to hippocampal perfusion measured by standard uptake value ratios (SUVRs): (1) PD hippocampal hypoperfusion group (1 standard deviation [SD] below the mean hippocampal SUVR of healthy controls; PD-hippo-hypo), (2) PD hippocampal hyperperfusion group (1 SD above the mean; PD-hippo-hyper), and (3) the remaining patients (PD-hippo-normal).

Risk of dementia in primary aldosteronism compared with essential hypertension: a nationwide cohort study.

Background: Although hypertension is a critical risk factor for dementia, the association between primary aldosteronism (PA) and dementia has been scarcely reported. We aimed to investigate whether the risk of dementia in patients with PA was elevated compared with patients with essential hypertension (EH).

Methods: From the National Health Insurance Claim database in Korea (2003-2017), 3,687 patients with PA (adrenalectomy [ADX], n = 1,339, mineralocorticoid receptor antagonist [MRA] n = 2,348) with no prior dementia were age- and sex-matched at a 1:4 ratio to patients with EH (n = 14,741).

Association of Neuropsychiatric Symptom Profiles With Cognitive Decline in Patients With Parkinson Disease and Mild Cognitive Impairment.

Background And Objectives: Neuropsychiatric symptoms (NPS) are closely associated with cognitive decline in patients with Parkinson disease (PD). We investigated which profiles of NPS are associated with the risk of dementia in PD with mild cognitive impairment (PD-MCI).

Methods: We retrospectively assessed 338 patients with PD-MCI from a single tertiary hospital, who underwent neuropsychological tests and a neuropsychiatric inventory (NPI) questionnaire.