Publications by authors named "Seisuke Nofuji"

Objective: The Japanese guidelines for male lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) recommend the water vapor energy therapy (WAVE) procedure only for patients in whom conventional BPH surgery is unsuitable due to advanced age or comorbidities. This study aims to evaluate the efficacy and safety of the WAVE procedure using the Rezum system in Japan.

Methods: This multicenter retrospective study included patients who underwent the WAVE procedure between August 2022 and December 2023.

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Objective: To clarify what urinary condition causes post micturition dribble (PMD) in non-elderly healthy men. We focused on men with PMD who do not have PMD every time they void. We clarified what urinary condition was associated with PMD in individuals to prevent PMD.

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Objective: To prospectively assess the impact of transurethral resection of the prostate (TURP) on detrusor function using pressure flow study (PFS) at 5 years after surgery in a single center prospective non-randomized observational study.

Methods: Sixty consecutive male patients were prospectively enrolled and underwent TURP from November 2014 to November 2018. A questionnaire survey, free uroflowmetry, and PFS were performed at baseline, and 6, 24, and 60 months after surgery.

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Article Synopsis
  • The study aimed to understand how patients feel about the potential loss of erectile function due to prostate cancer treatment.
  • Interviews were conducted with 20 patients scheduled for surgery, revealing that 70% were sad about losing sexual function and 85% wanted to preserve it.
  • Most participants (65%) were open to treatments to restore sexual function but preferred not to spend large amounts of money on such options.
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A 19-year-old man had been aware of dysuria and urinary incontinence since childhood but did not seek medical attention. He was diagnosed with acute pyelonephritis due to lower urinary tract dysfunction associated with spina bifida occulta and tethered cord syndrome (TCS) due to spinal cord lipoma. After placement of a urethral catheter and antibacterial chemotherapy, the patient was cured of acute pyelonephritis.

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Objectives: Our previous study suggested that the operative procedure is critical for the development of parastomal hernia. We developed a novel procedure for the creation of an ileal conduit stoma to prevent parastomal hernia. Herein we evaluate the efficacy and safety of the procedure.

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Article Synopsis
  • The study aimed to assess how effective local radiation therapy (LRT) is in preventing local symptoms associated with muscle-invasive bladder cancer (MIBC) by reviewing 133 patient records over five years.
  • Out of 114 patients analyzed, 26.3% experienced local symptoms such as hematuria and bladder pain, with certain risk factors like previous non-MIBC and lower radiation doses identified.
  • The findings suggest that increasing the radiation dose to 50 Gray or more could help reduce these local symptoms and improve care strategies for MIBC patients expected to have good survival outcomes.
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Objectives: We previously demonstrated the efficacy of cognitive behavioral therapy (CBT) using a self-check sheet for patients with nocturia in a randomized controlled study. Additionally, we investigated the efficacy of the intervention in real-world clinical practice.

Methods: Two hundred forty-three outpatients with complaint of nocturia who practiced CBT for 4 weeks using a self-check sheet were included in this trial, which took place from April 2021 to March 2022 in 20 institutions.

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Article Synopsis
  • The study aimed to evaluate the effectiveness of desmopressin orally disintegrating tablets (ODT) in reducing nighttime urination (nocturia) in male patients while analyzing factors that predict improvements.
  • Conducted at 27 institutions in Japan, the research included 118 male patients and found a persistence rate of about 51.3% after 12 weeks, with many discontinuing treatment due to adverse events, primarily hyponatremia.
  • Results showed significant reductions in nighttime frequency of urination, particularly for patients with larger nighttime urine volumes, indicating that desmopressin ODT is useful for male patients with nocturnal polyuria in real-world settings.
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A 44-year-old man was carried to the hospital in an ambulance because of dyspnea, paralysis and dysuria after signs of the flu. Acute encephalomyelitis was diagnosed by examination of magnetic resonance imaging. Antimicrobial treatment and respirator management was carried out with indwelling of urethral catheter for urinary retention.

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Although bacteremia is often concomitant with severe urinary tract infection (UTI), the treatment outcome has not been well studied. The aim of this study was to verify treatment outcome in patients with bacteremia caused by UTI. We also assessed the efficacy of sequential oral antibiotics.

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A 66-year-old woman was referred to our hospital because a bladder tumor was detected by abdominal ultrasonography. Although she was asymptomatic, cystoscopy showed the nodular sessile tumor in the bladder. We performed transurethral resection of the bladder tumor (TURBT) and histological examination revealed paraganglioma of the urinary bladder.

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A 74-year-old man visited our clinic for treatment of a retroperitoneal tumor that had enlarged gradually. We performed surgical resection of the tumor because we suspected retroperitoneal liposarcoma radiographically. The histopathological diagnosis was an atypical spindle cell lipomatous tumor.

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We report a case diagnosed as both necrotizing fasciitis and frostbite of the male external genetalia. The patient was a 58-year-old man with diabetes mellitus. He was referred to our hospital with swelling of his penis and icing there for 3 weeks.

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A 56-year-old man who had a 28mm renal mass on computed tomography (CT) pointed out at another hospital visited our department. The tumor was buried and located in the renal hilus, which was slightly enhanced in the early phase and washed out in the delayed phase. We diagnosed it as papillary renal cell carcinoma and conducted partial nephrectomy.

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