Genetic and molecular approaches for Fusarium wilt resistance in garden pea: advances and future outlook.

Garden pea is an important leguminous crop valued for its protein-rich food source for human nutrition and enhancing agricultural sustainability by fixing nitrogen biologically. However, its cultivation faces significant challenges from pests, diseases, and environmental stresses. Among these, Fusarium wilt (FW) caused by pathogen Fusarium oxysporum f.

Exopolysaccharides and biofilm forming microbial inoculant AB-13 acting in a consortium promotes growth of economically important medicinal plant Catharanthus roseus.

Biofilm and Exopolysaccharides (EPS) from bioinoculants have previously displayed industrial applications but their role as plant probiotics is underexplored. In this study, biofilm forming and exopolysaccharides producing microbe (AB-13) was isolated and molecular characterization was done along with plant growth promoting traits. Biofilm and EPS characterization was done by biophysical techniques like XRD, FTIR and SEM-EDAX which revealed amorphous nature, signature carbohydrate related peaks and surface morphology.

Ultralow Powered 2D MoS-Based Memristive Crossbar Array for Synaptic Applications.

Two-dimensional materials are increasingly integral to beyond-CMOS electronics, facilitating the development of emerging memristive device technology for information storage and neuromorphic computing. Despite their emergence, some critical challenges including low device yield, substantial device-to-device (D2D), and cycle-to-cycle (C2C) variability factors hinder the development of high-density memristive devices for future low-power electronic applications. Here, we demonstrate a memristive crossbar array (MCA) in which multilayer 2D MoS acts as a resistive switching layer that offers lower switching voltages with a few microseconds pulse width.

Explaining Type 2 Diabetes with Transcriptomic Signatures of Pancreatic β-Cell Dysfunction and Death Induced by Human Islet Amyloid Polypeptide.

Amyloid deposits formed by misfolding and aggregation of human islet amyloid polypeptide (hIAPP) are one of the key pathophysiological features of type 2 diabetes mellitus (T2DM) and have been associated with the loss of function and viability of the pancreatic β-cells. The molecular processes by which hIAPP induces cytotoxicity in these cells are not well understood. To the best of our knowledge, this is the first report describing findings from the combined analysis of Affymetrix microarray and high-throughput sequencing (HTS) Gene Expression Omnibus (GEO) datasets of h-transgenic (Tg) mice islets.

Genomics assisted mapping of earliness in pea (Pisum sativum L.).

Background: Garden pea (Pisum sativum L.), is a temperate crop belonging to the Leguminosae family. Early maturing pea varieties complete their growth cycle in ∼80-90 days and fits very well within the crop rotation of rice, wheat, and maize, thereby providing an extra source of income to the farmers.

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition.

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intricate interactions between cancer cells and the TME is crucial in understanding cancer progression and therapeutic challenges.

Metabolic perturbations associated with hIAPP-induced insulin resistance in skeletal muscles: Implications to the development of type 2 diabetes.

The human islet amyloid polypeptide (hIAPP) tends to misfold and self-assemble to form amyloid fibrils, which has been associated with the loss of function and viability of pancreatic β-cells in type 2 diabetes mellitus (T2DM). The role of hIAPP in the development of insulin resistance (a hallmark of T2DM) in skeletal muscles - the major sites for glucose utilization - needs further investigation. Even though, insulin-resistant conditions have been known to stimulate hIAPP aggregation, the events that lead to the development of insulin resistance due to hIAPP aggregation in skeletal muscles remain unidentified.

Silent epidemic of silicotuberculosis in India and emergence of multidrug-resistant tuberculosis?

Objectives: India's projected silica-dust-exposed workers will be 52 million at the end of 2025. The elimination of tuberculosis (TB) is also targeted in India by 2025. Scientists in India have already pointed out that unless silicosis is controlled, the said elimination will be difficult to achieve.

Efficacy of Bacillus Calmette-Guérin in Cancer Prevention and Its Putative Mechanisms.

Bacillus Calmette-Guérin (BCG) is an attenuated strain of . Although it was developed as a prophylactic vaccine against tuberculosis (TB), researchers have also evaluated it for preventing cancer development or progression. These studies were inspired by the available data regarding the protective effects of microbial infection against cancers and an inverse relationship between TB and cancer mortality.

Biofilm forming, exopolysaccharide producing and halotolerant, bacterial consortium mitigates salinity stress in Triticum aestivum.

Biofilm and EPS characterization of a rhizobacterial isolate BC-II-20 was done using biophysical techniques. SEM revealed surface morphology of EPS powder to be irregular porous web-like structure. FTIR spectra showed peaks of the polymeric carbohydrate functional groups with probable role in imparting biological properties to EPS.

Standardized agronomic practices for mechanical harvesting of the single-harvest garden pea in India.

The field investigations were conducted at Vegetable Research Farm, Department of vegetable Science, Punjab Agricultural University, Ludhiana with the objective to standarize the agronomic practices for mechical harvesting of garden pea. Therefore, effect of different agronomic traits including time of sowing, spacing and sowing method on yield and its attributing traits were studied on singleharvest garden pea. The experiment was laid out in split-plot design with 30 treatments comprising five dates of sowing in main plots and 2 different planting methods (flat and bed) sown at three different spacing in subplots and replicated three times.

Patent landscaping and citation network analysis to reveal the global research trends in biopriming using microbial inoculants: an insight toward sustainable agriculture.

As an alternative to harmful chemical fertilizers and toward fulfilling Sustainable Development Goals (SDGs) of the United Nations, growth promoting rhizobacterial bioinoculants, emerged as potential players. These act in multifunctional ways, including seed colonization, seed germination, stress tolerance and many more, leading to proper growth and development of plants. Biopriming seeds with these beneficial multi-trait microbes is an effective way to introduce them in the soil, and this is an example of bottom-up approach of rhizosphere engineering.

Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope.

Visceral sensory pathways mediate homeostatic reflexes, the dysfunction of which leads to many neurological disorders. The Bezold-Jarisch reflex (BJR), first described in 1867, is a cardioinhibitory reflex that is speculated to be mediated by vagal sensory neurons (VSNs) that also triggers syncope. However, the molecular identity, anatomical organization, physiological characteristics and behavioural influence of cardiac VSNs remain mostly unknown.

An isolated subcutaneous paraspinal pseudo-tumor-more to it than meets the eye-a case report and review of literature.

A 4-year-old male child presented to us with a paraspinal pseudo-tumor over the mid-back region with pain being his only symptom. On initial ultrasonography, it was presumed to be a nerve sheath tumor, but on an excision biopsy and histopathology, it proved to be a subcutaneous cysticercosis. Furthermore, an MRI of the brain showed a ring enhancing lesion with vasogenic edema, which confirmed the diagnosis of a neurologically symptomless neurocysticercosis.

TLR4 activation by lysozyme induces pain without inflammation.

Mostly, pain has been studied in association with inflammation, until recent studies which indicate that during bacterial infections, pain mechanisms could be independent of the inflammation. Chronic pain can sustain long after the healing from the injury, even in the absence of any visible inflammation. However, the mechanism behind this is not known.

Automatic diagnosis of COVID-19 with MCA-inspired TQWT-based classification of chest X-ray images.

In this era of Coronavirus disease 2019 (COVID-19), an accurate method of diagnosis with less diagnosis time and cost can effectively help in controlling the disease spread with the new variants taking birth from time to time. In order to achieve this, a two-dimensional (2D) tunable Q-wavelet transform (TQWT) based on a memristive crossbar array (MCA) is introduced in this work for the decomposition of chest X-ray images of two different datasets. TQWT has resulted in promising values of peak signal-to-noise ratio (PSNR) and structural similarity index measure (SSIM) at the optimum values of its parameters namely quality factor (Q) of 4, and oversampling rate (r) of 3 and at a decomposition level (J) of 2.

Patent intelligence of RNA viruses: Implications for combating emerging and re-emerging RNA virus based infectious diseases.

The recent outbreak of one of the RNA viruses (2019-nCoV) has affected most of the population and the fatalities reported may label it as a modern-day scourge. Active research on RNA virus infections and vaccine development had more commercial impact which leads to an increase in patent filings. Patents are a goldmine of information whose mining yields crucial technological inputs for further research.

Chemically Modified Dipeptide Based Hydrogel Supports Three-Dimensional Growth and Functions of Primary Hepatocytes.

A huge shortage of organ donors, particularly in the case of liver, has necessitated the development of alternative therapeutic strategies. Primary hepatocytes (pHCs) transplantation has made a considerable transition from bench to bedside, but the short-term viability and functionality of pHCs in in vitro limit their use for clinical applications. Different cell culture strategies are required to maintain the proliferation of pHCs for extended periods.

The role of potassium on drought resistance of winter wheat cultivars under cold dryland conditions: Probed by chlorophyll a fluorescence.

Potassium (K) is an important cation that regulates plant metabolism. Therefore the effect of different concentrations of potassium (0, 75, 150 kg ha KSO) on photosynthesis efficiency of three winter wheat cultivars (Baran, Homa, Hashtrud) was investigated during the growing seasons of 2017-18 and 2018-19 under cold dryland conditions in Maragheh, Iran. Accumulation of potassium ion (K) was observed to be increased with an increase in the concentration of KSO.

Does silicon really matter for the photosynthetic machinery in plants…?

Silicon (Si) is known to alleviate the adverse impact of different abiotic and biotic stresses by different mechanisms including morphological, physiological, and genetic changes. Photosynthesis, one of the most important physiological processes in the plant is sensitive to different stress factors. Several studies have shown that Si ameliorates the stress effects on photosynthesis by protecting photosynthetic machinery and its function.

Silver Nanoparticle's Toxicological Effects and Phytoremediation.

The advancement in nanotechnology has brought numerous benefits for humans in diverse areas including industry, medicine, and agriculture. The demand in the application of nanomaterials can result in the release of these anthropogenic materials into soil and water that can potentially harm the environment by affecting water and soil properties (e.g.

Assessment of Prevalence of Dental Caries among School-going Children: A Cross-sectional Study.

Background: The background of the study was to assess the prevalence of dental caries among school-going children.

Materials And Methods: Six thousand eight hundred and ninety school-going children was enrolled. General clinical examination was carried out.

Anti-tumor effects of an ID antagonist with no observed acquired resistance.

ID proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in cancer. ID proteins inhibit basic-HLH transcription factors often blocking differentiation and sustaining proliferation. A small-molecule, AGX51, targets ID proteins for degradation and impairs ocular neovascularization in mouse models.

Influence of different types of explants in chickpea regeneration using thidiazuron seed-priming.

A comparative regeneration of three types of explants prepared from axillary meristems, plumular apices and hypocotyls of chickpea (Cicer arietinum) was carried out using four thidiazuron (TDZ) treatment methods. The first and third ones included the short-term 20 μM TDZ pre-treatment for all three explant types followed by non-supplementation or supplementation of TDZ (4 μM) into the shoot induction medium (SIM), while the second and fourth ones lacked TDZ pre-treatment followed by non-addition or addition of 4 μM TDZ in the SIM. Axillary meristem explants produced the best results with seed pre-treatment using 20 μM TDZ without TDZ in SIM and showed the highest rate of regeneration efficiency (71.