Feasibility and Safety of Percutaneous Device Closure of Patent Ductus Arteriosus in Preterm Neonates: Experience From a Single Center in Northern India.

Objective: To report the feasibility and safety of percutaneous device closure of patent ductus arteriosus (PDA) in preterm neonates from a tertiary center in Northern India.

Methods: A retrospective chart review of the clinical profile, nature of device used, and outcomes of inborn preterm neonates who underwent percutaneous device closure of PDA was conducted. The intervention was performed by experienced pediatric cardiologists using a transvenous approach under fluoroscopic guidance.

Engineered L-asparaginase variants with enhanced therapeutic properties to improve treatment of childhood acute lymphatic leukemia.

Escherichia coli L-asparaginase (EcA), a key component of a multi-drug acute lymphatic leukemia (ALL) treatment regimen, has several limitations that reduce its therapeutic efficacy. The major disadvantages include immunogenicity, serum instability, shorter half-life, and accompanying glutaminase activity that causes neurotoxicity and pancreatitis. Pegylated asparaginase and Erwinase have better therapeutic potential, but they are expensive.

Congenitally Corrected Transposition of Great Arteries With Double Aortic Arch and Membranous Septal Aneurysm-A Rare Association.

We describe a case of congenitally corrected transposition of great arteries (ccTGA) with associated double aortic arch and membranous septal aneurysm. We describe the multimodality imaging features and clinical presentation due to these anomalies.

Methodological Appraisal and Evidence-Based Insights on Guided Tissue Regeneration in Endodontic Surgery: An Umbrella Review of Systematic Reviews and Meta-Analyses.

This study evaluated the methodological quality and synthesised evidence from systematic reviews on guided tissue regeneration (GTR) in endodontic surgery. A comprehensive search across multiple databases was conducted to identify systematic reviews published up to 21 November 2024, with no language restrictions. Methodological quality was assessed using the AMSTAR-2 tool, and primary study overlap using corrected covered area (CCA) metrics.

"Saw-Tooth" Cardiomyopathy in an Infant.

We hereby describe a case of saw tooth cardiomyopathy, which is a rare type of LV dysplasia, in an infant. We describe the multimodality imaging features that help to diagnose this entity.

Application of 3D printing for customised treatment of upper limb disorders.

Purpose: Three-dimensional (3D) technology is rapidly emerging as a valuable tool in the medical and healthcare industry, particularly for performing corrective osteotomies in upper limb extremities. This study involved patients with impaired upper limb function who underwent corrective osteotomies using a computer-assisted 3D surgical planning process with 3D-printed, patient-specific plates. The biomechanical performance of these 3D-printed, patient-specific plates was enhanced while maintaining crucial properties such as corrosion resistance and biocompatibility, ensuring their safety for clinical application in humans.

Dilated ascending aorta in neonates with congenital complete heart block: An interesting observation worth exploring.

Ascending aorta dilatation has been reported in some cases of congenital complete heart block (CHB). Although maternal autoantibodies are implicated in the causation, the exact mechanism, significance, and management are not fully understood. In this report, we describe dilated ascending aorta in two neonates with congenital CHB and their short-term follow-up results.

Healthy choices, healthy futures: promoting healthy nutrition to curb non-communicable diseases.

Non-communicable diseases (NCDs) pose a serious challenge to global public health, compounded by unhealthy nutrition and obesogenic environments. This science and society article emphasizes several evidence-based behavior-change strategies, policy interventions, and meaningful youth engagement to promote healthy nutrition choices among children and adolescents.

Giant Left Atrium in an Infant with Anomalous Origin of Left Coronary Artery from Pulmonary Artery.

Anomalous origin of the left coronary artery (ALCAPA) from the pulmonary artery is a rare congenital anomaly with coronary steal and myocardial ischemia. The left ventricular dilatation leads to mitral regurgitation causing left atrial enlargement. We report a rare case of giant left atrium in an infant with ALCAPA-mediated secondary mitral regurgitation, which has been hitherto unreported.

Obstructed infracardiac total anomalous pulmonary venous connection with patent ductus venosus: possibility of emergency palliation.

Background: Patients with obstructed infra-cardiac total anomalous pulmonary venous connection (TAPVC) require urgent intervention to relieve the obstruction, with or without restoration of anatomical continuity between the pulmonary veins and the left atrium. In cases of infra-cardiac TAPVC draining into the inferior vena cava (IVC) or hepatic vein, the obstructed channel can be accessed via the systemic venous approach for endovascular palliation. However, in cases of infra-cardiac TAPVC draining into the portal venous system, an endovascular approach to the obstructed channel is not possible via the transfemoral route and may require direct percutaneous puncture of the splenoportal axis.

Neurodevelopmental outcomes after infant heart surgery for congenital heart disease: a hospital-based multicentre prospective cohort study from India.

Background: Neurodevelopmental disability is a common long-term concern following surgery for congenital heart disease (CHD). Little information is available from low-resource environments where the majority of children with CHD are born. Several challenges in the CHD care continuum exist in such environments.

Systemic artery aneurysms - A marker of high-risk Kawasaki disease.

Kawasaki disease, traditionally classified as medium vessel vasculitis, is known for the preferential involvement of coronary arteries. Infrequently, large systemic arteries might be involved and may affect the prognosis. Here, we present an infant with Kawasaki disease who had extensive involvement of large vessels such as the abdominal aorta and medium vessels of the extremities, along with giant coronary artery aneurysms.

Computed tomography dataset virtual dissection for sternal re-entry in congenital cardiac surgery.

Unlabelled: In congenital heart surgery, redo-sternotomies are very common. In most cases, sternal re-entry is achieved without serious complications. However, sometimes elective institution of peripheral cardiopulmonary bypass is needed for safe sternotomy, albeit with a long cardio-pulmonary bypass time.

Transcatheter pulmonary valve implantation with custom-made 35-mm Myval™ transcatheter heart valve.

Transcatheter pulmonary valve implantation (TPVI) is the standard of care in patients with repaired tetralogy of Fallot (rTOF) presenting with right ventricular outflow tract (RVOT) dysfunction. However, the feasibility of TPVI is limited by the high cost and nonavailability of larger-sized valves for dilated native RVOT of rTOF patients. We report the first successful TPVI with a custom-made 35 mm balloon-expandable valve (Myval™) in a 30-year-old rTOF patient with severe pulmonary regurgitation and RV dysfunction.