Individual placement and support for young adults: One-year outcomes.

Objective: Many young adults who are unemployed and not in school need support achieving employment goals. Individual Placement and Support (IPS) is an evidence-based employment practice for adults with serious mental illness, but its applicability to young adults with mental health conditions has not been well-researched. The present study prospectively assessed IPS effectiveness in a national sample of young adults enrolled in routine practice settings in the U.

Individual placement and support programmes for young adults: Where are they and whom do they serve?

Aim: Individual Placement and Support (IPS), an evidence-based supported employment model developed for adults with serious mental illness, has been recently targeted to young adults with mental health conditions, but little is known about its adoption in this age group in the United States.

Methods: We recruited a volunteer sample of nine IPS programmes in five states serving young adults with mental health conditions aged 16 to 24. IPS team leaders reported programme and participant characteristics and rated barriers to employment and education.

A touchy subject: Ca signaling during leaf movements in Mimosa.

Mimosa pudica, the sensitive plant, responds to stimuli such as touch and wounding with leaf movements that propagate throughout the plant. The motion is driven by changes in the turgor of specialized cells in a set of motor organs called pulvinae. By imaging cellular Ca levels as the wave of movement propagates through the leaf, Hagihara and colleagues now show that Ca signals precede and predict the pulvinar movements.

Individual Placement and Support (IPS) for High School Aged Youth: Provider Perspective and Practice.

Semi-structured interviews were conducted with nine Individual Placement and Support (IPS) employment specialists who expanded and enhanced the IPS model for the youngest of working age youth with mental health conditions (ages 16-21). Semi-structured interviews were conducted with 100% of the providers delivering IPS-based career services for high school aged youth during an exploratory pilot. Content coding was applied to interview transcripts.

Using the Automated Botanical Contact Device (ABCD) to Deliver Reproducible, Intermittent Touch Stimulation to Plants.

Despite mechanical stimulation having profound effects on plant growth and development and modulating responses to many other stimuli, including to gravity, much of the molecular machinery triggering plant mechanical responses remains unknown. This gap in our knowledge arises in part from difficulties in applying reproducible, long-term touch stimulation to plants. We describe the design and implementation of the Automated Botanical Contact Device (ABCD) that applies intermittent, controlled, and highly reproducible mechanical stimulation by drawing a plastic sheet across experimental plants.

Variation in the transcriptome of different ecotypes of Arabidopsis thaliana reveals signatures of oxidative stress in plant responses to spaceflight.

Premise Of The Study: Spaceflight provides a unique environment in which to dissect plant stress response behaviors and to reveal potentially novel pathways triggered in space. We therefore analyzed the transcriptomes of Arabidopsis thaliana plants grown on board the International Space Station to find the molecular fingerprints of these space-related response networks.

Methods: Four ecotypes (Col-0, Ws-2, Ler-0 and Cvi-0) were grown on orbit and then their patterns of transcript abundance compared to ground-based controls using RNA sequencing.

Plants eavesdrop on cues produced by snails and induce costly defenses that affect insect herbivores.

Although induced defenses are widespread in plants, the degree to which plants respond to herbivore kairomones (incidental chemicals that herbivores produce independent of herbivory), the costs and benefits of responding to cues of herbivory risk, and the ecological consequences of induced defenses remain unclear. We demonstrate that undamaged tomatoes, Solanum lycopersicum, induce defenses in response to a kairomone (locomotion mucus) of snail herbivores (Helix aspersa). Induced defense had significant costs and benefits for plants: plants exposed to snail mucus or a standard defense elicitor (methyl jasmonate, MeJA) exhibited slower growth, but also experienced less herbivory by an insect herbivore (Spodoptera exigua).

Environmental and Genetic Factors Regulating Localization of the Plant Plasma Membrane H-ATPase.

A P-type H-ATPase is the primary transporter that converts ATP to electrochemical energy at the plasma membrane of higher plants. Its product, the proton-motive force, is composed of an electrical potential and a pH gradient. Many studies have demonstrated that this proton-motive force not only drives the secondary transporters required for nutrient uptake, but also plays a direct role in regulating cell expansion.

Barriers and Facilitators to Sustainment of an Evidence-Based Supported Employment Program.

Large-scale initiatives to expand evidence-based practices are often poorly implemented and rarely endure. The purpose of this study was to identify the perceived barriers and facilitators to sustainment of an evidence-based supported employment program, Individual Placement and Support (IPS). Within a 2-year prospective study of sustainment among 129 IPS programs in 13 states participating in a national learning community, we interviewed IPS team leaders and coded their responses to semi-structured interviews using a conceptual framework adapted from another large-scale implementation study.

The Rice E3-Ubiquitin Ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 Modulates the Expression of ROOT MEANDER CURLING, a Gene Involved in Root Mechanosensing, through the Interaction with Two ETHYLENE-RESPONSE FACTOR Transcription Factors.

Plant roots can sense and respond to a wide diversity of mechanical stimuli, including touch and gravity. However, little is known about the signal transduction pathways involved in mechanical stimuli responses in rice (Oryza sativa). This work shows that rice root responses to mechanical stimuli involve the E3-ubiquitin ligase rice HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 (OsHOS1), which mediates protein degradation through the proteasome complex.

A Controlled Trial of Supported Employment for People With Severe Mental Illness and Justice Involvement.

Objective: Employment is a key to participation in community life for people with severe mental illness, especially those who have been involved in the criminal justice system. Although the Individual Placement and Support (IPS) model of supported employment has been established as an evidence-based practice for helping people with severe mental illness attain competitive employment, little is known about whether IPS is effective for people with severe mental illness who have a history of arrest or incarceration. This study examined this question.

Evaluating mechano-transduction and touch responses in plant roots.

Mechanical forces can be imposed on plants either from the environment, through factors such as the weather, mechanical properties of the soil and animal movement, or through the internal forces generated by the interplay between turgor-driven growth and the rigid plant cell wall. Such mechanical cues have profound effects on plant growth and development leading to responses ranging from directional growth patterns as seen, e.g.

The potential of technology for enhancing individual placement and support supported employment.

Topic: The potential of technology to enhance delivery and outcomes of Individual Placement and Support (IPS) supported employment.

Purpose: IPS supported employment has demonstrated robust success for improving rates of competitive employment among individuals with psychiatric disabilities. Still, a majority of those with serious mental illnesses are not employed (Bond, Drake, & Becker, 2012).

Strategies for integrated employment and mental health services.

Objective: Individual placement and support (IPS) supported employment for people with mental illness is most effective when mental health and employment services are fully integrated within teams in a single agency. Despite this evidence, there are times when separate mental health and employment agencies must collaborate rather than integrate. This article examines how 3 state implementation teams helped separate agencies to partner on IPS supported employment.

Job development guidelines in supported employment.

Topic: This article describes methods for building relationships with employers that benefit both employers and job seekers.

Purpose: Many employment specialists receive little training on how to work with employers and, therefore, resort to online job searches. This article describes a simple framework for developing long-term relationships with employers.

Imaging changes in cytoplasmic calcium using the Yellow Cameleon 3.6 biosensor and confocal microscopy.

Changes in the concentration of cytoplasmic calcium, [Ca(2+)]cyt are central regulators in many cellular signal transduction pathways including many lipid-mediated regulatory networks. Given this central role that [Ca(2+)] has during plant growth, monitoring spatial and temporal [Ca(2+)] dynamics can reveal a critical component of cellular physiology. Here, we describe the measurement of [Ca(2+)]cyt in Arabidopsis root cells using plants expressing Yellow Cameleon 3.

Principles for enhancing the role of state vocational rehabilitation in IPS-supported employment.

Objective: Research has established the Individual Placement and Support (IPS) model of supported employment as an effective approach for persons with severe mental illnesses. This article examines strategies for Vocational Rehabilitation (VR) to enhance employment outcomes through better collaboration with IPS programs.

Methods: Twenty-one focus groups were conducted in rural and urban locations in Illinois with mental health consumers, VR counselors, IPS specialists, and mental health professionals.

Employer attitudes about criminal histories.

Objective: Although the individual placement and support (IPS) approach has demonstrated superior competitive employment outcomes for people with severe mental illness, practitioners report that job obtainment for people with criminal convictions is particularly challenging. The current study examined employer hiring decisions and attitudes regarding job applicants with felonies. The main purpose of the study was to identify the percentage of employers who had knowingly hired applicants with felonies, and if the hiring patterns differed by employer type.

High-resolution imaging of Ca2+ , redox status, ROS and pH using GFP biosensors.

Many plant response systems are linked to complex dynamics in signaling molecules such as Ca(2+) and reactive oxygen species (ROS) and to pH. Regulatory changes in these molecules can occur in the timeframe of seconds and are often limited to specific subcellular locales. Thus, to understand how Ca(2+) , ROS and pH form part of plants' regulatory networks, it is essential to capture their rapid dynamics with resolutions that span the whole plant to subcellular dimensions.

In vivo imaging of Ca2+, pH, and reactive oxygen species using fluorescent probes in plants.

Changes in the levels of Ca(2+), pH, and reactive oxygen species (ROS) are recognized as key cellular regulators involved in diverse physiological and developmental processes in plants. Critical to understanding how they exert such widespread control is an appreciation of their spatial and temporal dynamics at levels from organ to organelle and from seconds to many hours. With appropriate controls, fluorescent sensors can provide a robust approach with which to quantify such changes in Ca(2+), pH, and ROS in real time, in vivo.

Extracellular nucleotides elicit cytosolic free calcium oscillations in Arabidopsis.

Extracellular ATP induces a rise in the level of cytosolic free calcium ([Ca(2+)](cyt)) in plant cells. To expand our knowledge about the function of extracellular nucleotides in plants, the effects of several nucleotide analogs and pharmacological agents on [Ca(2+)](cyt) changes were studied using transgenic Arabidopsis (Arabidopsis thaliana) expressing aequorin or the fluorescence resonance energy transfer-based Ca(2+) sensor Yellow Cameleon 3.6.

Touch induces ATP release in Arabidopsis roots that is modulated by the heterotrimeric G-protein complex.

Amongst the many stimuli orienting the growth of plant roots, of critical importance are the touch signals generated as roots explore the mechanically complex soil environment. However, the molecular mechanisms behind these sensory events remain poorly defined. We report an impaired obstacle-avoiding response of roots in Arabidopsis lacking a heterotrimeric G-protein.